scholarly journals Incident Type 2 Diabetes and Risk of Fracture: A Comparative Cohort Analysis Using U.K. Primary Care Records

Diabetes Care ◽  
2020 ◽  
Vol 44 (1) ◽  
pp. 58-66
Author(s):  
Gabrielle S. Davie ◽  
Kingshuk Pal ◽  
Elizabeth Orton ◽  
Edward G. Tyrrell ◽  
Irene Petersen
Keyword(s):  
Type 2 Diabetes ◽  
Primary Care ◽  
Cohort Analysis ◽  
Risk Of Fracture ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals Incident type 2 diabetes and risk of fracture: a comparative cohort analysis using UK primary care records

2020 ◽  
Author(s):  
Gabrielle S Davie ◽  
Kingshuk Pal ◽  
Elizabeth Orton ◽  
Edward G Tyrrell ◽  
Irene Petersen
Keyword(s):  
Type 2 Diabetes ◽  
Primary Care ◽  
Lifestyle Changes ◽  
Health Improvement ◽  
Prevalence Rates ◽  
Risk Of Fracture ◽  
Incident Type ◽  
Increased Risk ◽  
Incident Type 2 Diabetes

<b>Objective </b>To estimate risk of fracture in men and women with recent diagnosis of type 2 diabetes compared to individuals without diabetes. <p><b>Research Design and Methods<strong> </strong></b>In this cohort study we used routinely-collected UK primary care data from The Health Improvement Network. In adults (>35 years) diagnosed with type 2 diabetes between 2004-2013 fractures sustained until 2019 were identified and compared to fractures sustained in individuals without diabetes. Multivariable models estimated time to first fracture following diagnosis of diabetes. Annual prevalence rates included at least one fracture in a given year. <strong></strong></p> <p><strong>Results </strong>Among 174,244 individuals with incident type 2 diabetes and 747,290 without diabetes, there was no increased risk of fracture among males with diabetes (adjusted hazards ratio (aHR) 0.97 (95%CI 0.94, 1.00)) and a small reduced risk among females (aHR 0.94, (95%CI 0.92, 0.96)). In those aged 85 years and over those in the diabetes cohort were at significantly lower risk of incident fracture (Males: aHR 0.85, 95%CI 0.71, 1.00; Females: aHR 0.85, 95%CI 0.78, 0.94). For those in the most deprived areas, aHRs were 0.90 (95%CI 0.83, 0.98) for males and 0.91 (95%CI 0.85, 0.97) for females. Annual fracture prevalence rates, by sex, were similar for those with and without type 2 diabetes.</p> <p><strong>Conclusion We found </strong>no evidence to suggest a higher risk of fracture following diagnosis of type 2 diabetes. After a diagnosis of type 2 diabetes individuals should be encouraged to make positive lifestyle changes, including undertaking weight-bearing physical activities that improve bone health.</p>

scholarly journals Incident type 2 diabetes and risk of fracture: a comparative cohort analysis using UK primary care records

2020 ◽  
Author(s):  
Gabrielle S Davie ◽  
Kingshuk Pal ◽  
Elizabeth Orton ◽  
Edward G Tyrrell ◽  
Irene Petersen
Keyword(s):  
Type 2 Diabetes ◽  
Primary Care ◽  
Lifestyle Changes ◽  
Health Improvement ◽  
Prevalence Rates ◽  
Risk Of Fracture ◽  
Incident Type ◽  
Increased Risk ◽  
Incident Type 2 Diabetes

<b>Objective </b>To estimate risk of fracture in men and women with recent diagnosis of type 2 diabetes compared to individuals without diabetes. <p><b>Research Design and Methods<strong> </strong></b>In this cohort study we used routinely-collected UK primary care data from The Health Improvement Network. In adults (>35 years) diagnosed with type 2 diabetes between 2004-2013 fractures sustained until 2019 were identified and compared to fractures sustained in individuals without diabetes. Multivariable models estimated time to first fracture following diagnosis of diabetes. Annual prevalence rates included at least one fracture in a given year. <strong></strong></p> <p><strong>Results </strong>Among 174,244 individuals with incident type 2 diabetes and 747,290 without diabetes, there was no increased risk of fracture among males with diabetes (adjusted hazards ratio (aHR) 0.97 (95%CI 0.94, 1.00)) and a small reduced risk among females (aHR 0.94, (95%CI 0.92, 0.96)). In those aged 85 years and over those in the diabetes cohort were at significantly lower risk of incident fracture (Males: aHR 0.85, 95%CI 0.71, 1.00; Females: aHR 0.85, 95%CI 0.78, 0.94). For those in the most deprived areas, aHRs were 0.90 (95%CI 0.83, 0.98) for males and 0.91 (95%CI 0.85, 0.97) for females. Annual fracture prevalence rates, by sex, were similar for those with and without type 2 diabetes.</p> <p><strong>Conclusion We found </strong>no evidence to suggest a higher risk of fracture following diagnosis of type 2 diabetes. After a diagnosis of type 2 diabetes individuals should be encouraged to make positive lifestyle changes, including undertaking weight-bearing physical activities that improve bone health.</p>

scholarly journals Serum testosterone, sex hormone-binding globulin and sex-specific risk of incident type 2 diabetes in a retrospective primary care cohort

2018 ◽  
Vol 90 (1) ◽  
pp. 145-154 ◽  
Author(s):  
Michael W. O’Reilly ◽  
Marija Glisic ◽  
Balachandran Kumarendran ◽  
Anuradhaa Subramanian ◽  
Konstantinos N. Manolopoulos ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Primary Care ◽  
Serum Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Incident Type ◽  
Specific Risk ◽  
Incident Type 2 Diabetes

[beta]eta-hydroxybutyrate and risk for incident type 2 diabetes: results from the prevend prospective cohort study

2019 ◽  
Author(s):  
Jose L Flores-Guerrero ◽  
Margery A Connelly ◽  
Dion Groothof ◽  
Eke G Gruppen ◽  
Stephan JL Bakker ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Incident Type ◽  
Incident Type 2 Diabetes
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