scholarly journals Good Glycemic Outcomes Following Bariatric Surgery Among Patients With Type 2 Diabetes, Obesity, and Low-Titer GAD Antibodies

Diabetes Care ◽  
2020 ◽  
pp. dc200804
Author(s):  
Ruveena Kaur ◽  
David Kim ◽  
Richard Cutfield ◽  
Michael Booth ◽  
Lindsay Plank ◽  
...  
2020 ◽  
Author(s):  
Ruveena Kaur ◽  
David Kim ◽  
Richard Cutfield ◽  
Michael Booth ◽  
Lindsay Plank ◽  
...  

<i>Objective</i>: To evaluate diabetes remission after bariatric surgery by presence of glutamic acid decarboxylase (GAD) antibody among those with obesity and Type 2 diabetes (T2D). <p> </p><i>Research Design and Methods</i>: Screening GAD was performed in 221 patients with T2D and obesity referred for bariatric surgery. 9/16 patients with GAD and 112/205 without GAD proceeded with surgery. Diabetes remission and weight loss was compared by GAD presence. <p> </p><i>Results</i>: GAD titres were 16-91 IU/mL in the first group. Both groups were similar in age, BMI, diabetes duration, insulin treated proportion, HbA1c and C-peptide (1354 ± 548 vs 1358 ± 487pmol/L). At 1 and 5 years post-operatively, both groups achieved similar BMI reduction and diabetes remission (67% vs 73%, p=0.71, and 56% vs 57%, p=1.0). <p><i> </i></p><i>Conclusion</i>: Low-titre GAD in patients with T2D and retained C-peptide, should not be a deterrent for bariatric surgery when the principal aim is diabetes remission.


2020 ◽  
Author(s):  
Ruveena Kaur ◽  
David Kim ◽  
Richard Cutfield ◽  
Michael Booth ◽  
Lindsay Plank ◽  
...  

<i>Objective</i>: To evaluate diabetes remission after bariatric surgery by presence of glutamic acid decarboxylase (GAD) antibody among those with obesity and Type 2 diabetes (T2D). <p> </p><i>Research Design and Methods</i>: Screening GAD was performed in 221 patients with T2D and obesity referred for bariatric surgery. 9/16 patients with GAD and 112/205 without GAD proceeded with surgery. Diabetes remission and weight loss was compared by GAD presence. <p> </p><i>Results</i>: GAD titres were 16-91 IU/mL in the first group. Both groups were similar in age, BMI, diabetes duration, insulin treated proportion, HbA1c and C-peptide (1354 ± 548 vs 1358 ± 487pmol/L). At 1 and 5 years post-operatively, both groups achieved similar BMI reduction and diabetes remission (67% vs 73%, p=0.71, and 56% vs 57%, p=1.0). <p><i> </i></p><i>Conclusion</i>: Low-titre GAD in patients with T2D and retained C-peptide, should not be a deterrent for bariatric surgery when the principal aim is diabetes remission.


2016 ◽  
Vol 22 ◽  
pp. 159
Author(s):  
Carolina Casellini ◽  
Joshua Edwards ◽  
Henri Parson ◽  
Kim Hodges ◽  
David Lieb ◽  
...  

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 126-LB ◽  
Author(s):  
STEPHANIE HABIF ◽  
ALEXANDRA CONSTANTIN ◽  
LARS MUELLER ◽  
HARSIMRAN SINGH

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2117-P
Author(s):  
REBECCA HILLYER ◽  
TRAVIS SULLIVAN ◽  
KIMBERLY CHRIST ◽  
AMEYA HODARKAR ◽  
MARY BETH HODGE

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