scholarly journals Insulin Resistance and Risk of Major Vascular Events and All-Cause Mortality in Type 1 Diabetes: A 10-Year Follow-up Study

Diabetes Care ◽  
2020 ◽  
Vol 43 (10) ◽  
pp. e139-e141 ◽  
Author(s):  
Monia Garofolo ◽  
Elisa Gualdani ◽  
Maria Giovanna Scarale ◽  
Cristina Bianchi ◽  
Michele Aragona ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 1 Diabetes ◽  
Vascular Events ◽  
Follow Up Study ◽  
All Cause Mortality

scholarly journals Comment on Garofolo et al. Insulin Resistance and Risk of Major Vascular Events and All-Cause Mortality in Type 1 Diabetes: A 10-Year Follow-up Study. Diabetes Care 2020;43:e139–e141

Diabetes Care ◽  
2021 ◽  
Vol 44 (4) ◽  
pp. e79-e80
Author(s):  
José-Miguel González-Clemente ◽  
Gemma Llauradó ◽  
Lara Albert ◽  
Olga Giménez-Palop ◽  
Eugenia Berlanga ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 1 Diabetes ◽  
Diabetes Care ◽  
Vascular Events ◽  
Follow Up Study ◽  
All Cause Mortality

Estimated Glucose Disposal Rate as a Predictor of All-Cause Mortality in Type 1 Diabetes—A 10-Year Follow-Up Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1694-P
Author(s):  
MONIA GAROFOLO ◽  
ALESSANDRA BERTOLOTTO ◽  
FABRIZIO CAMPI ◽  
DANIELA LUCCHESI ◽  
LAURA GIUSTI ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glucose Disposal ◽  
Follow Up Study ◽  
All Cause Mortality ◽  
Estimated Glucose Disposal Rate ◽  
Glucose Disposal Rate

Insulin resistance and risk of vascular events, interventions and mortality in type 1 diabetes

2021 ◽  
Author(s):  
Marga A.g. Helmink ◽  
Marieke de Vries ◽  
Frank L.j. Visseren ◽  
Wendela L. de Ranitz ◽  
Harold W. de Valk ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Insulin Sensitivity ◽  
Lower Risk ◽  
Cardiovascular Events ◽  
Additional Risk Factor ◽  
Vascular Events ◽  
All Cause Mortality

Objective: To identify determinants associated with insulin resistance and to assess the association between insulin resistance and cardiovascular events, vascular interventions and mortality in people with type 1 diabetes at high risk of cardiovascular disease . Design: Prospective cohort study. Methods: 195 people with type 1 diabetes from the Secondary Manifestations of ARTerial disease (SMART) cohort were included. Insulin resistance was quantified by the estimated glucose disposal rate (eGDR) with higher eGDR levels indicating higher insulin sensitivity (i.e. lower eGDR levels indicating higher insulin resistance). Linear regression models were used to evaluate determinants associated with eGDR. The effect of eGDR on cardiovascular events, cardiovascular events or vascular interventions (combined endpoint) and on all-cause mortality was analysed using Cox proportional hazards models adjusted for confounders. Results: In 195 individuals (median follow-up 12.9 years, IQR 6.7-17.0), a total of 25 cardiovascular events, 26 vascular interventions and 27 deaths were observed. High eGDR as a marker for preserved insulin sensitivity was independently associated with a lower risk of cardiovascular events (HR 0.75; 95%CI 0.61-0.91), a lower risk of cardiovascular events and vascular interventions (HR 0.74; 95%CI 0.63-0.87), and a lower risk of all-cause mortality (HR 0.81; 95%CI 0.67-0.98). Conclusions: Insulin resistance as measured by eGDR is an additional risk factor for cardiovascular disease in individuals with type 1 diabetes. Modification of insulin resistance by lifestyle interventions or pharmacological treatment could be a viable therapeutic target to lower the risk of cardiovascular disease.

Microvascular Disease Burden and All-Cause Mortality in Type 1 Diabetes-A 10-Year Follow-Up Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1572-P
Author(s):  
MONIA GAROFOLO ◽  
ROSA GIANNARELLI ◽  
MICHELE ARAGONA ◽  
DANIELA LUCCHESI ◽  
LAURA GIUSTI ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Disease Burden ◽  
Microvascular Disease ◽  
Follow Up Study ◽  
All Cause Mortality

scholarly journals Increased All-Cause Mortality in Patients With Type 1 Diabetes and High-Expression Mannan-Binding Lectin Genotypes: A 12-Year Follow-up Study

Diabetes Care ◽  
2015 ◽  
Vol 38 (10) ◽  
pp. 1898-1903 ◽  
Author(s):  
Jakob A. Østergaard ◽  
Steffen Thiel ◽  
Maria Lajer ◽  
Rudi Steffensen ◽  
Hans-Henrik Parving ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
High Expression ◽  
Follow Up Study ◽  
All Cause Mortality ◽  
Mannan Binding Lectin ◽  
Binding Lectin
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