scholarly journals Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study

Diabetes Care ◽  
2020 ◽  
Vol 43 (7) ◽  
pp. 1553-1556 ◽  
Author(s):  
Farid H. Mahmud ◽  
Antoine B.M. Clarke ◽  
Kariym C. Joachim ◽  
Esther Assor ◽  
Charlotte McDonald ◽  
...  
2020 ◽  
Author(s):  
Farid H. Mahmud ◽  
Antoine B.M. Clarke ◽  
Kariym C. Joachim ◽  
Esther Assor ◽  
Charlotte McDonald ◽  
...  

<b>Objective</b>: To describe Celiac Disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in type 1 diabetes patients asymptomatic for CD. <p><b>Research Design and Methods</b>: Asymptomatic patients (8-45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA1c and continuous glucose monitoring (CGM) over 12 months. </p> <p><b>Results</b>: Adults had higher CD-seropositivity rates than children (6.8%, 95%CI 4.9% to 8.2%, N=1298 vs. 4.7%; 95%CI 3.4% to 5.9%, N=1089, p=0.035) with lower rates of prior CD-screening (6.9% vs 44.2%, p<0.0001). 51 participants were randomized to a GFD (N=27) or GCD (N=24). No HbA1c differences were seen between groups (+0.14%, 1.5mmol/mol; 95%CI: -0.79 to 1.08; p=0.76) although greater post-prandial glucose increases (4-hr +1.5mmol/L; 95%CI: 0.4 to 2.7; p=0.014) emerged with a GFD.</p> <p><b>Conclusions</b>: CD is frequently observed in asymptomatic patients with type 1 diabetes and clinical vigilance is warranted with initiation of a GFD. </p>


2020 ◽  
Author(s):  
Farid H. Mahmud ◽  
Antoine B.M. Clarke ◽  
Kariym C. Joachim ◽  
Esther Assor ◽  
Charlotte McDonald ◽  
...  

<b>Objective</b>: To describe Celiac Disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in type 1 diabetes patients asymptomatic for CD. <p><b>Research Design and Methods</b>: Asymptomatic patients (8-45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA1c and continuous glucose monitoring (CGM) over 12 months. </p> <p><b>Results</b>: Adults had higher CD-seropositivity rates than children (6.8%, 95%CI 4.9% to 8.2%, N=1298 vs. 4.7%; 95%CI 3.4% to 5.9%, N=1089, p=0.035) with lower rates of prior CD-screening (6.9% vs 44.2%, p<0.0001). 51 participants were randomized to a GFD (N=27) or GCD (N=24). No HbA1c differences were seen between groups (+0.14%, 1.5mmol/mol; 95%CI: -0.79 to 1.08; p=0.76) although greater post-prandial glucose increases (4-hr +1.5mmol/L; 95%CI: 0.4 to 2.7; p=0.014) emerged with a GFD.</p> <p><b>Conclusions</b>: CD is frequently observed in asymptomatic patients with type 1 diabetes and clinical vigilance is warranted with initiation of a GFD. </p>


Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1579-P
Author(s):  
MICHELLE GOULD ◽  
FARID H. MAHMUD ◽  
ANTOINE B. CLARKE ◽  
ESTHER ASSOR ◽  
AMISH PARIKH ◽  
...  

2009 ◽  
Vol 47 (05) ◽  
Author(s):  
É Micskey ◽  
P Pánczél ◽  
L Blatniczky ◽  
K Lukács

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 224-LB
Author(s):  
JASON SLOANE ◽  
BIANCA PORNEALA ◽  
DEBORAH J. WEXLER

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1316-P
Author(s):  
ERIN ALVING ◽  
KRISTEN CARLIN ◽  
DALE LEE ◽  
ALISSA J. ROBERTS ◽  
JANE DICKERSON ◽  
...  

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1293-P
Author(s):  
CRISTY R. GENO RASMUSSEN ◽  
KATHLEEN WAUGH ◽  
JUDITH BAXTER ◽  
ANDREA STECK ◽  
BRIGITTE I. FROHNERT ◽  
...  

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