scholarly journals Faster Compared With Standard Insulin Aspart During Day-and-Night Fully Closed-Loop Insulin Therapy in Type 1 Diabetes: A Double-Blind Randomized Crossover Trial

Diabetes Care ◽  
2019 ◽  
Vol 43 (1) ◽  
pp. 29-36 ◽  
Author(s):  
Klemen Dovc ◽  
Claudia Piona ◽  
Gül Yeşiltepe Mutlu ◽  
Natasa Bratina ◽  
Barbara Jenko Bizjan ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Therapy ◽  
Insulin Aspart ◽  
Closed Loop ◽  
Crossover Trial ◽  
Double Blind ◽  
Randomized Crossover Trial

scholarly journals Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Suboptimally Controlled Adolescents With Type 1 Diabetes: A 3-Week, Free-Living, Randomized Crossover Trial

Diabetes Care ◽  
2016 ◽  
Vol 39 (11) ◽  
pp. 2019-2025 ◽  
Author(s):  
Martin Tauschmann ◽  
Janet M. Allen ◽  
Malgorzata E. Wilinska ◽  
Hood Thabit ◽  
Carlo L. Acerini ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Closed Loop ◽  
Crossover Trial ◽  
Insulin Delivery ◽  
Free Living ◽  
Randomized Crossover Trial

Hypoglycaemia with insulin aspart: a double-blind, randomised, crossover trial in subjects with Type 1 diabetes

2004 ◽  
Vol 21 (7) ◽  
pp. 769-775 ◽  
Author(s):  
S. R. Heller ◽  
S. Colagiuri ◽  
S. Vaaler ◽  
B. H. R. Wolffenbuttel ◽  
K. Koelendorf ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Aspart ◽  
Crossover Trial ◽  
Double Blind

Overnight automated type 1 diabetes control under MD-logic closed-loop system: a randomized crossover trial

2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Revital Nimri ◽  
Thomas Danne ◽  
Olga Kordonouri ◽  
Eran Atlas ◽  
Natasa Bratina ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Closed Loop ◽  
Crossover Trial ◽  
Loop System ◽  
Diabetes Control ◽  
Closed Loop System ◽  
System A ◽  
Randomized Crossover Trial

scholarly journals A Randomized Crossover Trial Comparing Glucose Control During Moderate-Intensity, High-Intensity, and Resistance Exercise With Hybrid Closed-Loop Insulin Delivery While Profiling Potential Additional Signals in Adults With Type 1 Diabetes

2021 ◽  
Author(s):  
Barbora Paldus ◽  
Dale Morrison ◽  
Dessi P. Zaharieva ◽  
Melissa H. Lee ◽  
Hannah Jones ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glucose Control ◽  
High Intensity ◽  
Kinetic Data ◽  
Closed Loop ◽  
Crossover Trial ◽  
Moderate Intensity ◽  
Post Exercise ◽  
Randomized Crossover Trial

<b>Objective</b>: To compare glucose control with hybrid closed loop (HCL) when challenged by moderate-intensity exercise (MIE), high-intensity intermittent exercise (HIE) and resistance exercise (RE) while profiling counter-regulatory hormones, lactate, ketones, and kinetic data in adults with type 1 diabetes. <p><b>Methods</b>: <a>Open-label multisite randomized crossover trial. </a><a>Adults with type 1 diabetes undertook 40 min of HIE, MIE, and RE in random order while using HCL (Medtronic 670G) with a temporary target set 2 hours prior to and during exercise and 15g carbohydrates if pre-exercise glucose was <126mg/dL, to prevent hypoglycemia.</a> Primary outcome was median (IQR) continuous glucose monitoring (CGM) time-in-range (TIR, 70-180 mg/dL) for 14 hours post-exercise commencement. Accelerometer data and venous glucose, ketones, lactate, and counter-regulatory hormones were measured for 280 min post-exercise commencement. </p> <p><b>Results</b>: Median TIR was 81% [67, 93]%, 91% [80, 94]%, and 80% [73, 89]% for 0-14 hours post-exercise commencement for HIE, MIE and RE, respectively (n=30), with no difference between exercise types (MIE v HIE; p=0.11, MIE v RE p=0.11, HIE v RE p=0.90). Time-below-range was 0% for all exercise bouts. For HIE and RE compared with MIE, there were greater increases respectively in noradrenaline (p=0.01, p=0.004), cortisol (p<0.001, p=0.001), lactate (p£0.001, p£0.001) and heart rate (p=0.007, p=0.015). During HIE compared with MIE, there were greater increases in growth hormone (p=0.024). </p> <p><b>Conclusions</b>: Under controlled conditions, HCL provided satisfactory glucose control with no difference between exercise type. Lactate, counter-regulatory hormones, and kinetic data differentiate type and intensity of exercise, and their measurement may help inform insulin needs during exercise. However, their potential utility as modulators of insulin dosing will be limited by the pharmacokinetics of subcutaneous insulin delivery. </p>

scholarly journals Closed-Loop Insulin Delivery Versus Sensor-Augmented Pump Therapy in Older Adults With Type 1 Diabetes (ORACL): A Randomized, Crossover Trial

Diabetes Care ◽  
2021 ◽  
pp. dc211667
Author(s):  
Sybil A. McAuley ◽  
Steven Trawley ◽  
Sara Vogrin ◽  
Glenn M. Ward ◽  
Spiros Fourlanos ◽  
...  
Keyword(s):  
Older Adults ◽  
Type 1 Diabetes ◽  
Closed Loop ◽  
Crossover Trial ◽  
Insulin Delivery ◽  
Pump Therapy ◽  
Randomized Crossover Trial

212-OR: Closed-Loop Increases Time-in-Range in Older Adults with Type 1 Diabetes Compared with Sensor-Augmented Pump Therapy: A Randomized Crossover Trial

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 212-OR
Author(s):  
SYBIL A. MCAULEY ◽  
SARA VOGRIN ◽  
STEVEN TRAWLEY ◽  
PETER G. COLMAN ◽  
SPIROS FOURLANOS ◽  
...  
Keyword(s):  
Older Adults ◽  
Type 1 Diabetes ◽  
Closed Loop ◽  
Crossover Trial ◽  
Pump Therapy ◽  
Randomized Crossover Trial ◽  
Time In Range

Effect of sitagliptin on glucose control in adult patients with Type 1 diabetes: a pilot, double-blind, randomized, crossover trial

2011 ◽  
Vol 28 (10) ◽  
pp. 1176-1181 ◽  
Author(s):  
S. L. Ellis ◽  
E. G. Moser ◽  
J. K. Snell-Bergeon ◽  
A. S. Rodionova ◽  
R. M. Hazenfield ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glucose Control ◽  
Crossover Trial ◽  
Adult Patients ◽  
Double Blind ◽  
Randomized Crossover Trial
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