scholarly journals Predictors of Recurrent Severe Hypoglycemia in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia During the HypoCOMPaSS Study

Diabetes Care ◽  
2019 ◽  
Vol 43 (1) ◽  
pp. 44-52 ◽  
Author(s):  
Anneliese J.S. Flatt ◽  
Stuart A. Little ◽  
Jane Speight ◽  
Lalantha Leelarathna ◽  
Emma Walkinshaw ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Severe Hypoglycemia ◽  
Impaired Awareness

scholarly journals Mortality in People With Type 1 Diabetes, Severe Hypoglycemia, and Impaired Awareness of Hypoglycemia Referred for Islet Transplantation

2018 ◽  
Vol 4 (11) ◽  
pp. e401 ◽  
Author(s):  
Melissa H. Lee ◽  
Glenn M. Ward ◽  
Richard J. MacIsaac ◽  
Kathy Howe ◽  
D. Jane Holmes-Walker ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Islet Transplantation ◽  
Severe Hypoglycemia ◽  
Impaired Awareness

scholarly journals The Impact of Severe Hypoglycemia and Impaired Awareness of Hypoglycemia on Relatives of Patients With Type 1 Diabetes

Diabetes Care ◽  
2003 ◽  
Vol 26 (4) ◽  
pp. 1106-1109 ◽  
Author(s):  
H. V. Jorgensen ◽  
U. Pedersen-Bjergaard ◽  
A. K. Rasmussen ◽  
K. Borch-Johnsen
Keyword(s):  
Type 1 Diabetes ◽  
Severe Hypoglycemia ◽  
Impaired Awareness ◽  
The Impact

Structural Gray and White Matter Differences in Patients With Type 1 Diabetes and Impaired Awareness of Hypoglycemia

2020 ◽  
Author(s):  
Nicole Stantonyonge ◽  
Frederic Sampedro ◽  
Jorge Méndez ◽  
Saül Martínez-Horta ◽  
Ana Chico ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
White Matter ◽  
Severe Hypoglycemia ◽  
Population Based ◽  
Cortical Surface ◽  
Cross Sectional ◽  
Increased Risk ◽  
Impaired Awareness ◽  
Brain Changes

Abstract Context Type 1 diabetes (T1D) is associated with an increased risk of cognitive decline, where severe hypoglycemia (SH) and impaired awareness of hypoglycemia (IAH) may play a role. While there is evidence of a possible association between IAH and brain damage, the potential brain changes remain poorly characterized by magnetic resonance imaging (MRI). Objective To investigate whether there are structural brain differences in a group of T1D patients with IAH compared with normal awareness of hypoglycemia (NAH). Design General practice, population-based, cross-sectional study (July 2018 to July 2019). Setting Endocrinology Department, Hospital Santa Creu i Sant Pau. Participants A total of 40 T1D patients (20 each with IAH and NAH) matched for age, sex, T1D duration, and education level. Main Outcome Measures Using different neuroimaging techniques, we compared whole-brain gray matter (GM) and white matter (WM) differences. We used voxel-based morphometry and cortical surface area analysis methods to assess GM differences, and fractional anisotropy (FA) to assess WM differences. Results Compared with patients with T1D-NAH, patients with T1D-IAH had reduced GM volumes and cortical surface areas, especially in frontal and parietal regions (P < 0.05 corrected), and also showed reduced FA values in major WM tracts. The observed MRI differences correlated with both SH frequency and IAH severity. Conclusions MRI for patients with T1D show that IAH is associated with brain changes involving both GM and WM. Further research is needed to elucidate whether the observed differences are a consequence of increased SH episode frequency and increased IAH severity.

scholarly journals Impaired awareness of hypoglycemia in children and adolescents with type 1 diabetes mellitus in north of Jordan

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Mohammad J. Alkhatatbeh ◽  
Nedaa A. Abdalqader ◽  
Mohammad A. Y. Alqudah
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Severe Hypoglycemia ◽  
Common Symptom ◽  
Insulin Regimen ◽  
Impaired Awareness ◽  
Type 1 Dm

Abstract Background Hypoglycemia is a common complication of insulin therapy in patients with Type 1 Diabetes Mellitus (DM). Awareness of hypoglycemic symptoms helps patients to recognize hypoglycemia and initiate self-treatment. Impaired Awareness of Hypoglycemia (IAH) exposes patients to severe hypoglycemia, which could be associated with seizures and unconsciousness. This study aimed to assess IAH, frequency of hypoglycemia, severe hypoglycemia and intensity of hypoglycemic symptoms among children and adolescents with Type 1 DM in North of Jordan. Methods Data were collected from 94 children and adolescents with Type 1 DM. Clarke’s and Edinburgh surveys were used to assess IAH and individual symptoms of hypoglycemia, respectively. Frequency of hypoglycemia and other related information were obtained by self-reporting or from medical records. Results 16.0% of participants were having IAH, 66.0% of participants reported recurrent hypoglycemia (>once/month) and 18.0% of participants developed ≥1 severe hypoglycemia during the previous year. IAH was not associated with age, gender, duration of DM, HbA1c, insulin regimen, adherence to insulin or development of severe hypoglycemia (p-values> 0.05). Instead, IAH was associated with frequency of hypoglycemia during the previous 6 months (p-value< 0.01). Hunger, tiredness, dizziness, drowsiness, inability to concentrate, trembling and weakness were the most common symptoms felt by participants when they develop hypoglycemia. Hunger was the only common symptom that was significantly higher in children compared to adolescent (p-value < 0.01). Conclusions This study has reported low prevalence of IAH in children and adolescents with Type 1 DM in North of Jordan. IAH was more common in subjects with more frequent hypoglycemia.

Severe hypoglycemia, impaired awareness of hypoglycemia, and self-monitoring in adults with type 1 diabetes: Results from Diabetes MILES—Australia

2017 ◽  
Vol 31 (3) ◽  
pp. 577-582 ◽  
Author(s):  
Christel Hendrieckx ◽  
Virginia Hagger ◽  
Alicia Jenkins ◽  
Timothy Chas Skinner ◽  
Frans Pouwer ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Severe Hypoglycemia ◽  
Self Monitoring ◽  
Impaired Awareness
Sign in / Sign up

Export Citation Format

Share Document