scholarly journals A Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen (TWO2) Therapy in the Treatment of Chronic Diabetic Foot Ulcers: The TWO2 Study

Diabetes Care ◽  
2019 ◽  
Vol 43 (3) ◽  
pp. 616-624 ◽  
Author(s):  
Robert G. Frykberg ◽  
Peter J. Franks ◽  
Michael Edmonds ◽  
Jonathan N. Brantley ◽  
Luc Téot ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Controlled Trial ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Double Blinded

Efficacy of intralesional recombinant human epidermal growth factor in diabetic foot ulcers in Mexican patients: A randomized double-blinded controlled trial

2014 ◽  
Vol 22 (4) ◽  
pp. 497-503 ◽  
Author(s):  
Ramiro Gomez-Villa ◽  
Francisco Aguilar-Rebolledo ◽  
Adriana Lozano-Platonoff ◽  
Juan Miguel Teran-Soto ◽  
Maria Rosy Fabian-Victoriano ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Diabetic Foot ◽  
Controlled Trial ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Human Epidermal Growth Factor ◽  
Epidermal Growth ◽  
Double Blinded ◽  
Mexican Patients

Multinational, Multicenter, Prospective, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen Therapy (TWO2) in the Treatment of Chronic Diabetic Foot Ulcers

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 43-LB ◽  
Author(s):  
ROBERT FRYKBERG ◽  
PETER J. FRANKS ◽  
MICHAEL E. EDMONDS ◽  
JONATHAN N. BRANTLEY ◽  
LUC TÉOT ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Oxygen Therapy ◽  
Controlled Trial ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Double Blinded

scholarly journals Cellular Proliferation, Dermal Repair, and Microbiological Effectiveness of Ultrasound-Assisted Wound Debridement (UAW) Versus Standard Wound Treatment in Complicated Diabetic Foot Ulcers (DFU): An Open-Label Randomized Controlled Trial

2020 ◽  
Vol 9 (12) ◽  
pp. 4032
Author(s):  
José Luis Lázaro-Martínez ◽  
Francisco Javier Álvaro-Afonso ◽  
David Sevillano-Fernández ◽  
Yolanda García-Álvarez ◽  
Irene Sanz-Corbalan ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Cellular Proliferation ◽  
Controlled Trial ◽  
Surgical Debridement ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Wound Debridement ◽  
Randomized Controlled ◽  
Ultrasound Assisted ◽  
Surgical Group

We aimed to evaluate the effects of ultrasound-assisted wound (UAW) debridement on cellular proliferation and dermal repair in complicated diabetic foot ulcers as compared to diabetic foot ulcers receiving surgical/sharp wound debridement. A randomized controlled trial was performed involving 51 outpatients with complicated diabetic foot ulcers that either received surgical debridement (n = 24) or UAW debridement (n = 27) every week during a six-week treatment period. Compared to patients receiving surgical debridement, patients treated with UAW debridement exhibited significantly improved cellular proliferation, as determined by CD31 staining, Masson’s trichrome staining, and actin staining. Bacterial loads were significantly reduced in the UAW debridement group compared to the surgical group (UAW group 4.27 ± 0.37 day 0 to 2.11 ± 0.8 versus surgical group 4.66 ± 1.21 day 0 to 4.39 ± 1.24 day 42; p = 0.01). Time to healing was also significantly lower (p = 0.04) in the UAW group (9.7 ± 3.8 weeks) compared to the surgical group (14.8 ± 12.3 weeks), but both groups had similar rates of patients that were healed after six months of follow-up (23 patients (85.1%) in the UAW group vs. 20 patients (83.3%) in the surgical group; p = 0.856). We propose that UAW debridement could be an effective alternative when surgical debridement is not available or is contraindicated for use on patients with complicated diabetic foot ulcers.

scholarly journals The LeucoPatch® system in the management of hard-to-heal diabetic foot ulcers: study protocol for a randomised controlled trial

Trials ◽  
2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Frances Game ◽  
William Jeffcoate ◽  
Lise Tarnow ◽  
Florence Day ◽  
Deborah Fitzsimmons ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Study Protocol ◽  
Diabetic Foot ◽  
Controlled Trial ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Randomised Controlled
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