scholarly journals Change in Cardiovascular Health and Incident Type 2 Diabetes and Impaired Fasting Glucose: The Whitehall II Study

Diabetes Care ◽  
2019 ◽  
Vol 42 (10) ◽  
pp. 1981-1987 ◽  
Author(s):  
Rachel E. Climie ◽  
Thomas T. van Sloten ◽  
Marie-Cécile Périer ◽  
Muriel Tafflet ◽  
Aurore Fayosse ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Impaired Fasting Glucose ◽  
Cardiovascular Health ◽  
Fasting Glucose ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals Association of Alcohol Drinking With Incident Type 2 Diabetes and Pre-diabetes: the Guangzhou Biobank Cohort Study

2021 ◽  
Author(s):  
Mei Jiao Li ◽  
Jing Ren ◽  
Wei Sen Zhang ◽  
Chao Qiang Jiang ◽  
Ya Li Jin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Polymorphisms ◽  
Impaired Fasting Glucose ◽  
Alcohol Drinking ◽  
Fasting Glucose ◽  
Heavy Alcohol ◽  
Incident Type ◽  
Incident Type 2 Diabetes

Abstract Background To examine associations of baseline alcohol drinking with incident type 2 diabetes or impaired fasting glucose, and explore whether the associations were modified by genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2) and alcohol dehydrogenase-1B (ADH1B).Methods Information of alcohol consumption was collected at baseline from 2003 to 2008. Incident type 2 diabetes was defined as fasting glucose ≥7.0 mmol/l or post-load glucose ≥11.1 mmol/l at follow-up examination (2008-2012), self-reported type 2 diabetes and/or initiation of hypoglycemia medication or insulin during follow-up. Impaired fasting glucose was defined as fasting glucose ≥5.6 mmol/l and <7 mmol/l. Results Of 15,716 participants without diabetes and 11,232 participants without diabetes and impaired fasting glucose at baseline, 1,624 (10.33%) developed incident type 2 diabetes, and 1,004 (8.94%) developed incident impaired fasting glucose during average 4 years of follow-up. After adjusting for sex, age, education, occupation, personal annual income, smoking, physical activity, body mass index, waist/hip ratio, health status, family history of diabetes, compared with never drinking, occasional or moderate alcohol drinking was not associated with risk of incident type 2 diabetes+impaired fasting glucose (odds ratio (OR) 1.08, 95% confidence interval (CI) 0.94-1.25, and 0.89 (0.68-1.16), respectively), but heavy alcohol drinking was associated with a higher risk of incident type 2 diabetes+impaired fasting glucose (1.83, 1.25-2.69). No interactions of sex, overweight/obesity and genetic polymorphisms of ADH1B or ALDH2 genes with alcohol drinking on incident type 2 diabetes and/or impaired fasting glucose were found (p for interaction from 0.12 to 0.81). Conclusions Our results support a detrimental effect of heavy alcohol use on impaired fasting glucose and type 2 diabetes. No protective effect was found for those carrying lower risk alleles for ADH1B and ALDH2 genes.

scholarly journals Increased leisure-time physical activity associated with lower onset of diabetes in 44 828 adults with impaired fasting glucose: a population-based prospective cohort study

2018 ◽  
Vol 53 (14) ◽  
pp. 895-900 ◽  
Author(s):  
Xiang Qian Lao ◽  
Han-Bing Deng ◽  
Xudong Liu ◽  
Ta-Chien Chan ◽  
Zilong Zhang ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 2 Diabetes ◽  
Prospective Cohort ◽  
Leisure Time ◽  
Fasting Glucose ◽  
Leisure Time Physical Activity ◽  
Chinese Adults ◽  
Incident Type ◽  
Incident Type 2 Diabetes

AimsTo evaluate the effects of habitual leisure-time physical activity (LTPA) on incident type 2 diabetes in a prospective cohort of Chinese adults with impaired fasting glucose (IFG).Methods44 828 Chinese adults aged 20–80 years with newly detected IFG but free from cardiovascular and cerebrovascular disease were recruited and followed up from 1996 to 2014. Incident type 2 diabetes was identified by fasting plasma glucose ≥7 mmol/L. The participants were classified into four categories based on their self-reported weekly LTPA: inactive, low, moderate, or high. Hazard ratios (HRs) and population attributable fractions (PAFs) were estimated with adjustment for established diabetic risk factor.ResultsAfter 214 148 person-years of follow-up, we observed an inverse dose–response relationship between LTPA and diabetes risk. Compared with inactive participants, diabetes risk in individuals reporting low, moderate and high volume LTPA were reduced by 12% (HR 0.88, 95% CI 0.80 to 0.99; P=0.015), 20% (HR 0.80, 95% CI 0.71 to 0.90; P<0.001), and 25% (HR 0.75, 95% CI 0.67 to 0.83; P<0.001), respectively. At least 19.2% (PAF 19.2%, 95% CI 5.9% to 30.6%) of incident diabetes cases could be avoided if the inactive participants had engaged in WHO recommendation levels of LTPA. This would correspond to a potential reduction of at least 7 million diabetic patients in the Greater China area.ConclusionsOur results show higher levels of LTPA are associated with a lower risk of diabetes in IFG subjects. These data emphasise the urgent need for promoting physical activity as a preventive strategy against diabetes to offset the impact of population ageing and the growing obesity epidemic.

scholarly journals The association of ideal cardiovascular health with incident type 2 diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis

Diabetologia ◽  
2016 ◽  
Vol 59 (9) ◽  
pp. 1893-1903 ◽  
Author(s):  
Joshua J. Joseph ◽  
Justin B. Echouffo-Tcheugui ◽  
Mercedes R. Carnethon ◽  
Alain G. Bertoni ◽  
Christina M. Shay ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiovascular Health ◽  
Ethnic Study ◽  
Ideal Cardiovascular Health ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals Circulating and DietaryTransFatty Acids and Incident Type 2 Diabetes in Older Adults: The Cardiovascular Health Study

Diabetes Care ◽  
2015 ◽  
Vol 38 (6) ◽  
pp. 1099-1107 ◽  
Author(s):  
Qianyi Wang ◽  
Fumiaki Imamura ◽  
Wenjie Ma ◽  
Molin Wang ◽  
Rozenn N. Lemaitre ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Incident Type ◽  
Incident Type 2 Diabetes
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