scholarly journals Impact of Excessive Weight Gain on Cardiovascular Outcomes in Type 1 Diabetes: Results From the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study

Diabetes Care ◽  
2017 ◽  
Vol 40 (12) ◽  
pp. 1756-1762 ◽  
Author(s):  
Jonathan Q. Purnell ◽  
Barbara H. Braffett ◽  
Bernard Zinman ◽  
Rose A. Gubitosi-Klug ◽  
William Sivitz ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Weight Gain ◽  
Cardiovascular Outcomes ◽  
Diabetes Control ◽  
Excessive Weight Gain ◽  
Excessive Weight ◽  
Diabetes Interventions

scholarly journals Effect of Excessive Weight Gain With Intensive Therapy of Type 1 Diabetes on Lipid Levels and Blood Pressure

JAMA ◽  
1998 ◽  
Vol 280 (2) ◽  
pp. 140 ◽  
Author(s):  
Jonathan Q. Purnell ◽  
John E. Hokanson ◽  
Santica M. Marcovina ◽  
Michael W. Steffes ◽  
Patricia A. Cleary ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Weight Gain ◽  
Intensive Therapy ◽  
Lipid Levels ◽  
Excessive Weight Gain ◽  
Excessive Weight

scholarly journals Hearing Impairment and Type 1 Diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Cohort

Diabetes Care ◽  
2018 ◽  
Vol 41 (12) ◽  
pp. 2495-2501 ◽  
Author(s):  
David S. Schade ◽  
Gayle M. Lorenzi ◽  
Barbara H. Braffett ◽  
Xiaoyu Gao ◽  
Kathleen E. Bainbridge ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Hearing Impairment ◽  
Diabetes Control ◽  
Diabetes Interventions

Beyond the Diabetes Control and Complications Trial—Addressing Weight Gain in Type 1 Diabetes

2008 ◽  
Vol 04 (01) ◽  
pp. 62 ◽  
Author(s):  
Jonathan Purnell
Keyword(s):  
Type 1 Diabetes ◽  
Weight Gain ◽  
Microvascular Complications ◽  
Intensive Therapy ◽  
Diabetes Control ◽  
Controlled Clinical Trial ◽  
Normal Range ◽  
Randomised Controlled ◽  
Blood Glucose Concentrations

The Diabetes Control and Complications Trial (DCCT) was a prospective, randomised, controlled clinical trial that began in the 1980s and was carried out over a decade to determine whether intensive treatment aimed at maintaining blood glucose concentrations close to the normal range could decrease the frequency and severity of microvascular complications in patients with type 1 diabetes. The results showed that intensive therapy effectively delays the onset and progression of diabetic retinopathy, nephropathy, and neuropathy in patients with type 1 diabetes.1The side effects associated with intensive therapy were a nearly three-fold increased frequency of severe hypoglycaemia and greater weight gain. For the majority of patients with type 1 diabetes, the benefits of intensive therapy were considered to vastly outweigh these risks. However, the potential detrimental effects of weight gain, especially on macrovascular risks, are being revisited.

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