scholarly journals BMI and All-Cause Mortality in Normoglycemia, Impaired Fasting Glucose, Newly Diagnosed Diabetes, and Prevalent Diabetes: A Cohort Study

Diabetes Care ◽  
2017 ◽  
Vol 40 (8) ◽  
pp. 1026-1033 ◽  
Author(s):  
Eun Young Lee ◽  
Yong-ho Lee ◽  
Sang-Wook Yi ◽  
Soon-Ae Shin ◽  
Jee-Jeon Yi
Keyword(s):  
Cohort Study ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Newly Diagnosed ◽  
All Cause Mortality ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes

scholarly journals Increased Arterial Stiffness in Prediabetic Subjects Recognized by Hemoglobin A1c with Postprandial Glucose but Not Fasting Glucose Levels

2019 ◽  
Vol 8 (5) ◽  
pp. 603
Author(s):  
Chung-Hao Li ◽  
Feng-Hwa Lu ◽  
Yi-Ching Yang ◽  
Jin-Shang Wu ◽  
Chih-Jen Chang
Keyword(s):  
Arterial Stiffness ◽  
Hemoglobin A1c ◽  
Pulse Wave ◽  
Glycated Hemoglobin ◽  
Fasting Glucose ◽  
Postprandial Glucose ◽  
Newly Diagnosed ◽  
Glucose Levels ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes

Previous studies exploring the association between arterial stiffness and prediabetes remain controversial. This study aimed to investigate the association of the different domains of prediabetes categorized by glycated hemoglobin A1c (A1c) 5.7–6.4%, impaired fasting glucose (IFG), fasting plasma glucose of 5.6–6.9 mmol/L, and impaired glucose tolerance (IGT), two-hour post-load glucose of 7.8–11.0 mmol/L, on arterial stiffness. These were measured by brachial–ankle pulse-wave velocity (baPWV). We enrolled 4938 eligible subjects and divided them into the following nine groups: (1) normoglycemic; (2) isolated A1c 5.7–6.4%; (3) isolated IFG; (4) IFG with A1c 5.7–6.4%; (5) isolated IGT; (6) combined IGT and IFG with A1c <5.7%; (7) IGT with A1c 5.7–6.4%; (8) combined IGT and IFG with A1c 5.7–6.4%; and (9) newly diagnosed diabetes (NDD). The baPWV values were significantly high in subjects with NDD (β = 47.69, 95% confidence interval (CI) = 29.02–66.37, p < 0.001), those with IGT with A1c 5.7–6.4% (β = 36.02, 95% CI = 19.08–52.95, p < 0.001), and those with combined IGT and IFG with A1c 5.7–6.4% (β = 27.72, 95% CI = 0.68–54.76, p = 0.044), but not in the other subgroups. These findings suggest that increased arterial stiffness was found in prediabetes individuals having an A1c 5.7–6.4% with IGT, but not IFG. Isolated A1c 5.7–6.4% and isolated IGT were not associated with elevated arterial stiffness.

scholarly journals Increased Risk of Cirrhosis and Its Decompensation in Chronic Hepatitis B Patients With Newly Diagnosed Diabetes: A Nationwide Cohort Study

2013 ◽  
Vol 57 (12) ◽  
pp. 1695-1702 ◽  
Author(s):  
Yi-Wen Huang ◽  
Ting-Chuan Wang ◽  
Shih-Chang Lin ◽  
Han-Yu Chang ◽  
Ding-Shinn Chen ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Cohort Study ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Newly Diagnosed ◽  
Increased Risk ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes

scholarly journals No evidence of long-term disruption of glycometabolic control after SARS-CoV-2 infection

2021 ◽  
Author(s):  
Andrea Laurenzi ◽  
Amelia Caretto ◽  
Chiara Molinari ◽  
Alessia Mercalli ◽  
Raffaella Melzi ◽  
...  
Keyword(s):  
Public Health ◽  
Health Problem ◽  
Fasting Glucose ◽  
Fasting Blood Glucose ◽  
Public Health Problem ◽  
Newly Diagnosed ◽  
Markers Of Inflammation ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes

Abstract Purpose To assess whether dysglycaemia diagnosed during SARS-CoV-2 pneumonia may become a potential public health problem after resolution of the infection. In an adult cohort with suspected COVID-19 pneumonia, we integrated glucose data upon hospital admission with fasting blood glucose (FBG) in the year prior to COVID-19 and during post-discharge follow-up. Methods From February 25th to May 15th 2020 660 adults with suspected COVID-19 pneumonia were admitted to the San Raffaele Hospital (Milan, Italy). Through structured interviews / medical record reviews we collected demographics, clinical features and laboratory tests upon admission and additional data during hospitalization or after discharge and in the previous year. Upon admission, we classified participants according to ADA criteria as having: a) pre-existing diabetes; b) newly diagnosed diabetes; c) hyperglycaemia not in the diabetes range; d) normoglycaemia. FBG prior to admission and during follow-up were classified as normal or impaired fasting glucose and fasting glucose in the diabetes range. Results In patients with confirmed COVID (n=589) the proportion with pre-existing or newly diagnosed diabetes, hyperglycaemia not in the diabetes range and normoglycaemia was 19.6%, 6.7%, 43.7% and 30.0%, respectively. Patients with dysglycaemia associated to COVID-19 had increased markers of inflammation and organs’ injury and poorer clinical outcome compared to those with normoglycemia. After the infection resolved, the prevalence of dysglycaemia reverted to pre-admission frequency. Conclusions COVID-19 associated dysglycaemia is unlikely to become a lasting public health problem. Alarmist claims on the diabetes risk after COVID-19 pneumonia should be interpreted with caution.

scholarly journals Glycemic Measures and Risk of Mortality in Older Chinese: The Guangzhou Biobank Cohort Study

2019 ◽  
Vol 105 (3) ◽  
pp. e181-e190 ◽  
Author(s):  
Chao Qiang Jiang ◽  
Lin Xu ◽  
Tai Hing Lam ◽  
Ya Li Jin ◽  
Wei Sen Zhang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Confidence Interval ◽  
Mortality Risk ◽  
Fasting Glucose ◽  
Tolerance Test ◽  
Hazard Ratio ◽  
Oral Glucose ◽  
Risk Of Mortality ◽  
All Cause Mortality ◽  
Diagnosed Diabetes

Abstract Context China has the largest number of people with type 2 diabetes mellitus (T2DM) in the world. Data from previous studies have suggested that up to one-fifth of individuals with diabetes would be missed without an oral glucose tolerance test (OGTT). To date, there is little information on the mortality risk of these individuals. Objective We estimated the association of different indicators of hyperglycemia with mortality in the general Chinese population. Design Prospective cohort study. Setting China. Participants A total of 17 939 participants aged 50+ years. Exposures Previously diagnosed diabetes and newly detected diabetes defined by fasting glucose (≥7.0 mmol/L), 2-hour postload glucose (≥11.1 mmol/L), or hemoglobin A1c (HbA1c, ≥6.5%). Main Outcomes Measures Deaths from all-cause, cardiovascular disease, and cancer were identified by record linkage with death registration. Results During 7.8 (SD, 1.5) years’ follow-up, 1439 deaths were recorded. Of 3706 participants with T2DM, 2126 (57%) had known T2DM, 118 (3%) were identified by isolated elevated fasting glucose, 1022 (28%) had isolated elevated postload glucose, and 440 (12%) had both elevated fasting and postload glucose. Compared with normoglycemia, the hazard ratio (95% confidence interval) of all-cause mortality was 1.71 (1.46-2.00), 0.96 (0.47-1.93), 1.43 (1.15-1.78), and 1.82 (1.35-2.45) for the 4 groups, respectively. T2DM defined by elevated HbA1c was not significantly associated with all-cause mortality (hazard ratio, 1.17; 95% confidence interval, 0.81-1.69). Conclusion Individuals with isolated higher 2-h postload glucose had a higher risk of mortality by 43% than those with normoglycemia. Underuse of OGTT leads to substantial underdetection of individuals with a higher mortality risk and lost opportunities for early intervention.

scholarly journals Trends of Diagnosis-Specific Work Disability After Newly Diagnosed Diabetes: A 4-Year Nationwide Prospective Cohort Study

Diabetes Care ◽  
2015 ◽  
Vol 38 (10) ◽  
pp. 1883-1890 ◽  
Author(s):  
Marianna Virtanen ◽  
Jenni Ervasti ◽  
Ellenor Mittendorfer-Rutz ◽  
Petter Tinghög ◽  
Tea Lallukka ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Work Disability ◽  
Specific Work ◽  
Newly Diagnosed ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes

scholarly journals Anthocyanins increase serum adiponectin in newly diagnosed diabetes but not in prediabetes: a randomized controlled trial

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Liping Yang ◽  
Wenhua Ling ◽  
Yun Qiu ◽  
Yong Liu ◽  
Li Wang ◽  
...  
Keyword(s):  
Fasting Glucose ◽  
Controlled Trial ◽  
Epidemiological Studies ◽  
Serum Adiponectin ◽  
Newly Diagnosed ◽  
Anthropometric Parameters ◽  
Significant Difference ◽  
Before And After ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes

Abstract Background Epidemiological studies have suggested that adiponectin is associated with the development of insulin resistance and type 2 diabetes. This study first examined the effect of purified anthocyanins, a group of dietary flavonoids, on serum adiponectin in patients with prediabetes and newly diagnosed diabetes. Methods A total of 160 patients with prediabetes (n = 90) or newly diagnosed diabetes (n = 70) were randomly assigned to either the anthocyanins group or the placebo group for 12 weeks of intervention. Serum adiponectin, a set of biomarkers related to glucolipid metabolism, anthropometric parameters, dietary intake and physical activity were measured before and after intervention. Results Anthocyanins increased serum adiponectin compared with placebo (net change 0.46 µg/mL, 95% CI [0.03, 0.90], p = 0.038) in the subjects with newly diagnosed diabetes. No significant difference in the change in adiponectin was observed between the two groups either in the overall subjects (0.02 µg/mL [− 0.32, 0.36], p = 0.906) or in prediabetes (− 0.35 µg/mL [− 0.85, 0.16], p = 0.174). Anthocyanins also decreased fasting glucose (− 0.5 mmol/L [− 1, − 0.04], p = 0.035) in the subjects with newly diagnosed diabetes, but no such change was observed in those with prediabetes. Conclusions Anthocyanins supplementation for 12 weeks improved serum adiponectin and fasting glucose in patients with newly diagnosed diabetes, but not in patients with prediabetes. Trial registration ClinicalTrials.gov, NCT02689765. Registered on 6 February 2016, https://clinicaltrials.gov/ct2/show/NCT02689765.

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