scholarly journals A Contemporary Estimate of Total Mortality and Cardiovascular Disease Risk in Young Adults With Type 1 Diabetes: The Pittsburgh Epidemiology of Diabetes Complications Study

Diabetes Care ◽  
2016 ◽  
Vol 39 (12) ◽  
pp. 2296-2303 ◽  
Author(s):  
Rachel G. Miller ◽  
Hemant D. Mahajan ◽  
Tina Costacou ◽  
Akira Sekikawa ◽  
Stewart J. Anderson ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Young Adults ◽  
Diabetes Complications ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Total Mortality

scholarly journals Risk stratification for 25-year cardiovascular disease incidence in type 1 diabetes: Tree-structured survival analysis of the Pittsburgh Epidemiology of Diabetes Complications study

2016 ◽  
Vol 13 (4) ◽  
pp. 250-259 ◽  
Author(s):  
Rachel G Miller ◽  
Stewart J Anderson ◽  
Tina Costacou ◽  
Akira Sekikawa ◽  
Trevor J Orchard
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Survival Analysis ◽  
Diabetes Complications ◽  
Disease Risk ◽  
Clinical Pathways ◽  
Disease Incidence ◽  
Cardiovascular Disease Risk ◽  
Diabetes Duration

Background: The formal identification of subgroups with varying levels of risk is uncommon in observational studies of cardiovascular disease, although such insight might be useful for clinical management. Methods: Tree-structured survival analysis was utilized to determine whether there are meaningful subgroups at varying levels of cardiovascular disease risk in the Pittsburgh Epidemiology of Diabetes Complications study, a prospective cohort study of childhood-onset (<17 years old) type 1 diabetes. Results: Of the 561 participants free of cardiovascular disease (coronary artery disease, stroke or lower extremity arterial disease) at baseline, 263 (46.9%) had an incident cardiovascular disease event over the 25-year follow-up. Tree-structured survival analysis revealed a range of risk groups, from 24% to 85%, which demonstrate that those with short diabetes duration and elevated non–high-density lipoprotein cholesterol have similar cardiovascular disease risk to those with long diabetes duration and that renal disease is a better discriminator of risk in men than in women. Conclusion: Our findings suggest that subgroups with major cardiovascular disease risk differences exist in this type 1 diabetes cohort. Using tree-structured survival analysis may help to identify these groups and the interrelationships between their associated risk factors. This approach may improve our understanding of various clinical pathways to cardiovascular disease and help target intervention strategies.

Alcohol consumption or cigarette smoking and cardiovascular disease risk in youth with type 1 diabetes

2019 ◽  
Vol 56 (12) ◽  
pp. 1315-1321 ◽  
Author(s):  
Giuliana Valerio ◽  
Enza Mozzillo ◽  
Eugenio Zito ◽  
Elena De Nitto ◽  
Giulio Maltoni ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Alcohol Consumption ◽  
Cigarette Smoking ◽  
Disease Risk ◽  
Cardiovascular Disease Risk

Physical Activity Is Associated With Decreased Cardiovascular Disease Risk Factors In Children With Type 1 Diabetes

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S338-S339
Author(s):  
Nathalie J. Farpour-Lambert ◽  
Laetitia Keller-Marchand ◽  
Magali Oehrli ◽  
Didier Hans ◽  
Valerie Schwitzgebe ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cardiovascular Disease Risk Factors

scholarly journals Sex-Related Differences in Cardiovascular Disease Risk Profile in Children and Adolescents with Type 1 Diabetes

2021 ◽  
Vol 22 (19) ◽  
pp. 10192
Author(s):  
Darja Smigoc Schweiger ◽  
Tadej Battelino ◽  
Urh Groselj
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Risk Profile ◽  
Cvd Risk Factors ◽  
Cvd Risk

Cardiovascular disease (CVD) is the primary cause of higher and earlier morbidity and mortality in people with type 1 diabetes (T1D) compared to people without diabetes. In addition, women with T1D are at an even higher relative risk for CVD than men. However, the underlying pathophysiology is not well understood. Atherosclerotic changes are known to progress early in life among people with T1D, yet it is less clear when excess CVD risk begins in females with T1D. This review explores the prevalence of classical CVD risk factors (such as glycemic control, hypertension, dyslipidemia, obesity, albuminuria, smoking, diet, physical inactivity), as well as of novel biomarkers (such as chronic inflammation), in children and adolescents with T1D with particular regard to sex-related differences in risk profile. We also summarize gaps where further research and clearer clinical guidance are needed to better address this issue. Considering that girls with T1D might have a more adverse CVD risk profile than boys, the early identification of and sex-specific intervention in T1D would have the potential to reduce later CVD morbidity and excess mortality in females with T1D. To conclude, based on an extensive review of the existing literature, we found a clear difference between boys and girls with T1D in the presence of individual CVD risk factors as well as in overall CVD risk profiles; the girls were on the whole more impacted.

scholarly journals Dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes: A single-center experience

2021 ◽  
Vol 12 (1) ◽  
pp. 56-68
Author(s):  
Sari Krepel Volsky ◽  
Shlomit Shalitin ◽  
Elena Fridman ◽  
Michal Yackobovitch-Gavan ◽  
Liora Lazar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cardiovascular Disease Risk Factors ◽  
Single Center ◽  
Single Center Experience

Cardiovascular disease risk in type 1 diabetes – Authors' reply

2015 ◽  
Vol 3 (5) ◽  
pp. 317 ◽  
Author(s):  
Rachel R Huxley ◽  
Sanne A E Peters ◽  
Gita D Mishra ◽  
Mark Woodward
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Disease Risk ◽  
Cardiovascular Disease Risk
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