scholarly journals Nonalcoholic Fatty Liver Disease Is Prevalent in Women With Prior Gestational Diabetes Mellitus and Independently Associated With Insulin Resistance and Waist Circumference

Diabetes Care ◽  
2016 ◽  
Vol 40 (1) ◽  
pp. 109-116 ◽  
Author(s):  
Signe Foghsgaard ◽  
Camilla Andreasen ◽  
Louise Vedtofte ◽  
Emilie S. Andersen ◽  
Emilie Bahne ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Liver Disease ◽  
Waist Circumference ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver

scholarly journals The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

2020 ◽  
Vol 2020 ◽  
pp. 1-16 ◽  
Author(s):  
Daniela Maria Tanase ◽  
Evelina Maria Gosav ◽  
Claudia Florida Costea ◽  
Manuela Ciocoiu ◽  
Cristina Mihaela Lacatusu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver

Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.

scholarly journals Nonalcoholic fatty liver disease and the risk of insulin-requiring gestational diabetes

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Sang Youn You ◽  
Kyungdo Han ◽  
Seung-Hawn Lee ◽  
Mee Kyoung Kim
Keyword(s):  
Diabetes Mellitus ◽  
Liver Disease ◽  
Gestational Diabetes ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Health Examination ◽  
Nonalcoholic Fatty Liver ◽  
Increased Risk ◽  
Glutamyl Transferase

Abstract Background Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases; however, there has been little research into its impact on gestational diabetes mellitus (GDM). Methods This study included 308,095 women registered in the Korean National Health Insurance Service database, who delivered between 2011 and 2015 and received a health examination within 52 weeks before pregnancy. Insulin-requiring GDM was defined as no insurance claims for diabetes mellitus and a fasting blood glucose level of < 126 mg/dL before pregnancy, and initiation of insulin treatment during pregnancy. A fatty liver index (FLI) was calculated using body mass index, waist circumference, and blood triglyceride and γ-glutamyl transferase levels. FLI scores < 30 ruled out hepatic steatosis, while FLI scores ≥ 60 indicated NAFLD. Results The prevalence of NAFLD was 0.8% (2355/308,095) and 1984 (0.6%) subjects developed insulin-requiring GDM. FLIs of 30–59 and ≥ 60 were significantly associated with increased risk of insulin-requiring GDM (odds ratio [OR] 3.50; 95% confidence interval [CI] 2.99–4.10; OR 4.19; 95% CI 3.37–5.23), respectively. Further exploration of the association of FLI with GDM across FLI decile categories revealed a steady increase in OR across the categories. The association was more prominent among those without metabolic syndrome. Conclusion NAFLD in women is an independent risk factor for insulin-requiring GDM.

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