scholarly journals The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study

Diabetes Care ◽  
2016 ◽  
Vol 40 (1) ◽  
pp. 46-53 ◽  
Author(s):  
Maria Grau-Pérez ◽  
Chin-Chi Kuo ◽  
Miranda Spratlen ◽  
Kristina A. Thayer ◽  
Michelle A. Mendez ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Case Control Study ◽  
Arsenic Exposure ◽  
Case Control ◽  
Control Study ◽  
Diabetes In Youth

scholarly journals The association of arsenic exposure and metabolism with Type 1 and Type 2 Diabetes in youth: The SEARCH Case-Control Study

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Maria Grau Pérez* ◽  
Chin-Chi Kuo ◽  
Miranda Spratlen ◽  
Kristina Thayer ◽  
Michelle Ann Mendez ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Case Control Study ◽  
Arsenic Exposure ◽  
Case Control ◽  
Control Study ◽  
Diabetes In Youth

scholarly journals Breast-Feeding and Type 2 Diabetes in the Youth of Three Ethnic Groups: The SEARCH for Diabetes in Youth Case-Control Study

Diabetes Care ◽  
2007 ◽  
Vol 31 (3) ◽  
pp. 470-475 ◽  
Author(s):  
E. J. Mayer-Davis ◽  
D. Dabelea ◽  
A. P. Lamichhane ◽  
R. B. D'Agostino ◽  
A. D. Liese ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Ethnic Groups ◽  
Breast Feeding ◽  
Case Control Study ◽  
Case Control ◽  
Control Study ◽  
Diabetes In Youth

scholarly journals HbA 1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study

2018 ◽  
Vol 32 (2) ◽  
pp. 203-209 ◽  
Author(s):  
Victor W. Zhong ◽  
Juhaeri Juhaeri ◽  
Stephen R. Cole ◽  
Christina M. Shay ◽  
Penny Gordon-Larsen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

Alexithymia impact on type 1 and type 2 diabetes: A case-control study

2014 ◽  
Vol 75 (4) ◽  
pp. 213-219 ◽  
Author(s):  
Leila Mnif ◽  
Rahma Damak ◽  
Fatma Mnif ◽  
Sami Ouanes ◽  
Mohamed Abid ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

Perinatal Risk Factors in Young Adult-Onset Type 1 and Type 2 Diabetes—A Population-Based Case-Control Study

2009 ◽  
Vol 64 (8) ◽  
pp. 511-512
Author(s):  
Niina Lammi ◽  
Paul A. Blomstedt ◽  
Elena Moltchanova ◽  
Johan G. Eriksson ◽  
Jaakko Tuomilehto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Adult Onset ◽  
Perinatal Risk Factors ◽  
Control Study

scholarly journals Characteristics of the Gut Microbiota and Metabolism in Patients With Latent Autoimmune Diabetes in Adults: A Case-Control Study

2021 ◽  
Author(s):  
Yuanyuan Fang ◽  
Chenhong Zhang ◽  
Hongcai Shi ◽  
Wei Wei ◽  
Jing Shang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Gut Microbiota ◽  
Case Control Study ◽  
Autoimmune Diabetes ◽  
Case Control ◽  
Latent Autoimmune Diabetes ◽  
Control Study

OBJECTIVE <p>Type 1 and type 2 diabetes are associated with gut dysbiosis. However, the relationship between the gut microbiota and latent autoimmune diabetes in adults (LADA), sharing clinical and metabolic features with classic type 1 and type 2 diabetes, remains unclear. Here, we identified the characteristics of the gut microbiota and metabolic profiles in patients with LADA using a multi-omics approach.</p> <p>RESEARCH DESIGN AND METHODS</p> <p>This age- and sex-matched case-control study included 30 patients with LADA, 31 patients with classic type 1 diabetes, 30 patients with type 2 diabetes, and 29 healthy individuals. The gut microbiota profiles were identified via the 16S rRNA gene, and fecal and serum metabolites were measured via untargeted liquid chromatography-mass spectrometry.</p> <p>RESULTS </p> <p>LADA patients had a significantly different structure and composition of the gut microbiota and their metabolites as well as a severe deficiency of short-chain fatty acid-producing bacteria. The gut microbiota structure of the LADA patients was more similar to that of patients with type 1 diabetes who were positive for GAD antibody. We identified seven serum metabolite modules and eight fecal metabolite modules that differed between the LADA group and the other groups.</p> <p>CONCLUSIONS </p> <p><a>The characteristic gut microbiota and related metabolites of patients with LADA are associated with autoantibodies, glucose metabolism, islet function, and inflammatory factors, which may contribute to the pathogenesis of LADA. </a>Future longitudinal studies should explore whether modulating the gut microbiota and related metabolites can alter the natural course of autoimmune diabetes, in the quest for new therapeutic.</p>

scholarly journals Association of Intrauterine Exposure to Maternal Diabetes and Obesity With Type 2 Diabetes in Youth: The SEARCH Case-Control Study

Diabetes Care ◽  
2008 ◽  
Vol 31 (7) ◽  
pp. 1422-1426 ◽  
Author(s):  
D. Dabelea ◽  
E. J. Mayer-Davis ◽  
A. P. Lamichhane ◽  
R. B. D'Agostino ◽  
A. D. Liese ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Case Control Study ◽  
Maternal Diabetes ◽  
Case Control ◽  
Intrauterine Exposure ◽  
Diabetes And Obesity ◽  
Control Study ◽  
Diabetes In Youth

scholarly journals Characteristics of the Gut Microbiota and Metabolism in Patients With Latent Autoimmune Diabetes in Adults: A Case-Control Study

2022 ◽  
Author(s):  
Yuanyuan Fang ◽  
Chenhong Zhang ◽  
Hongcai Shi ◽  
Wei Wei ◽  
Jing Shang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Gut Microbiota ◽  
Case Control Study ◽  
Autoimmune Diabetes ◽  
Case Control ◽  
Latent Autoimmune Diabetes ◽  
Control Study

OBJECTIVE <p>Type 1 and type 2 diabetes are associated with gut dysbiosis. However, the relationship between the gut microbiota and latent autoimmune diabetes in adults (LADA), sharing clinical and metabolic features with classic type 1 and type 2 diabetes, remains unclear. Here, we identified the characteristics of the gut microbiota and metabolic profiles in patients with LADA using a multi-omics approach.</p> <p>RESEARCH DESIGN AND METHODS</p> <p>This age- and sex-matched case-control study included 30 patients with LADA, 31 patients with classic type 1 diabetes, 30 patients with type 2 diabetes, and 29 healthy individuals. The gut microbiota profiles were identified via the 16S rRNA gene, and fecal and serum metabolites were measured via untargeted liquid chromatography-mass spectrometry.</p> <p>RESULTS </p> <p>LADA patients had a significantly different structure and composition of the gut microbiota and their metabolites as well as a severe deficiency of short-chain fatty acid-producing bacteria. The gut microbiota structure of the LADA patients was more similar to that of patients with type 1 diabetes who were positive for GAD antibody. We identified seven serum metabolite modules and eight fecal metabolite modules that differed between the LADA group and the other groups.</p> <p>CONCLUSIONS </p> <p><a>The characteristic gut microbiota and related metabolites of patients with LADA are associated with autoantibodies, glucose metabolism, islet function, and inflammatory factors, which may contribute to the pathogenesis of LADA. </a>Future longitudinal studies should explore whether modulating the gut microbiota and related metabolites can alter the natural course of autoimmune diabetes, in the quest for new therapeutic.</p>

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