scholarly journals Cardiovascular Autonomic Neuropathy, Sexual Dysfunction, and Urinary Incontinence in Women With Type 1 Diabetes

Diabetes Care ◽  
2016 ◽  
Vol 39 (9) ◽  
pp. 1587-1593 ◽  
Author(s):  
James M. Hotaling ◽  
Aruna V. Sarma ◽  
Darshan P. Patel ◽  
Barbara H. Braffett ◽  
Patricia A. Cleary ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Urinary Incontinence ◽  
Sexual Dysfunction ◽  
Autonomic Neuropathy ◽  
Cardiovascular Autonomic Neuropathy

322-OR: Risk Factors for Peripheral and Cardiovascular Autonomic Neuropathy in Type 1 Diabetes: Thirty Years of Follow-Up in DCCT/EDIC

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 322-OR
Author(s):  
BARBARA BRAFFETT ◽  
ROSE GUBITOSI-KLUG ◽  
JAMES W. ALBERS ◽  
EVA L. FELDMAN ◽  
CATHERINE MARTIN ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Autonomic Neuropathy ◽  
Cardiovascular Autonomic Neuropathy

Diabetic cardiovascular autonomic neuropathy in children

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
O.L.G.A Gumeniuk ◽  
N Bolotova ◽  
A Averianov ◽  
I.U Chernenkov
Keyword(s):  
Heart Rate ◽  
Type 1 Diabetes ◽  
Autonomic Neuropathy ◽  
Hba1c Level ◽  
Diabetes Duration ◽  
Cardiovascular Autonomic Neuropathy ◽  
Deep Breath ◽  
Group I ◽  
Diabetic Cardiovascular Autonomic Neuropathy

Abstract   Diabetic cardiovascular autonomic neuropathy (CAN) encompasses damage to the autonomic nerve fibers innervating the heart and blood vessels, resulting in abnormalities in heart rate control and vascular dynamics. Clinical symptoms associated with CAN include resting tachycardia, postural hypotension, dizziness, syncope, exercise intolerance, silent myocardial infarction. The earliest finding of CAN, even at the subclinical stage, is a decrease in heart rate variability (HRV) Purpose To study CAN prevalence and understand the diagnostic capabilities of HRV - tests of diabetic cardiovascular autonomic neuropathy in children with type 1 diabetes. Methods 100 children with type 1 diabetes were assessed for CAN (age 15.2 yrs [9.0–17.8], duration 6.5 yrs [4.0–10.6], HbA1c 8.1% 6.3–9.7]). The degree of compensation of diabetes was estimated according to criteria ISPAD Consensus Guidelines, 2018. Optimal level (HbA1c <7.0%) of compensation was revealed in 62% of children (group I) and nonoptimal in 38% of children (group II). For evaluation of the CAN we used HRV - tests: RR 30:15 ratio, ΔRR quiet breath, ΔRR deep breath, BP response to standing. Results Diabetic cardiovascular autonomic neuropathy was diagnosed in 41 children: in group I – in 6 (29%) and in group II – 35 (71%) children (p=0.00001). The prevalence of DCN correlated with HbA1c level in children and adolescents (groups I and II): ΔRR quiet breath r=−0.47 & r=−0.9; ΔRR deep breath r=−0.65 & r=−0.85; RR30:15 r=−0.77 & r=−0.88 respectively. Prevalence of CAN increased parallel to type 1 diabetes duration (p<0.01). Conclusions Diabetic cardiovascular autonomic neuropathy in children with type 1 diabetes was diagnosed in 41%. Prevalence of diabetic cardiovascular autonomic neuropathy increases parallel to type 1 diabetes duration (p<0.01). In this study we found an association between HRV indexes and HbA1c level. This provides support for HRV - testing to assess diabetic cardiovascular autonomic neuropathy in children. Funding Acknowledgement Type of funding source: None

scholarly journals Predictors of Cardiovascular Autonomic Neuropathy in Patients with Type 1 Diabetes

2014 ◽  
Vol 5 ◽  
Author(s):  
Lucianne Righeti Monteiro Tannus ◽  
Karla Rezende Guerra Drummond ◽  
Eliete Leão da Silva Clemente ◽  
Maria de Fátima Bevilacqua da Matta ◽  
Marilia Brito Gomes ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Autonomic Neuropathy ◽  
Cardiovascular Autonomic Neuropathy

scholarly journals Cardiovascular Autonomic Neuropathy and Glucose Variability in Patients With Type 1 Diabetes: Is There an Association?

2018 ◽  
Vol 9 ◽  
Author(s):  
Szabolcs Nyiraty ◽  
Fruzsina Pesei ◽  
Andrea Orosz ◽  
Sara Coluzzi ◽  
Orsolya Eszter Vági ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Autonomic Neuropathy ◽  
Glucose Variability ◽  
Cardiovascular Autonomic Neuropathy

scholarly journals Circulating Inflammatory Markers Are Inversely Associated with Heart Rate Variability Measures in Type 1 Diabetes

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Anne-Marie L. Wegeberg ◽  
Tina Okdahl ◽  
Tina Fløyel ◽  
Christina Brock ◽  
Niels Ejskjaer ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 1 Diabetes ◽  
Adhesion Molecules ◽  
Autonomic Neuropathy ◽  
Vagal Tone ◽  
Cardiovascular Autonomic Neuropathy ◽  
Intercellular Adhesion Molecule ◽  
Cardiac Vagal Tone

Introduction. A neuroimmune communication exists, and compelling evidence suggests that diabetic neuropathy and systemic inflammation are linked. Our aims were (1) to investigate biomarkers of the ongoing inflammation processes including cytokines, adhesion molecules, and chemokines and (2) to associate the findings with cardiovascular autonomic neuropathy in type 1 diabetes by measuring heart rate variability and cardiac vagal tone. Materials and Methods. We included 104 adults with type 1 diabetes. Heart rate variability, time domain, and frequency domains were calculated from a 24-hour Holter electrocardiogram, while cardiac vagal tone was determined from a 5-minute electrocardiogram. Cytokines (interleukin- (IL-) 1α, IL-4, IL-12p70, IL-13, IL-17, and tumor necrosis factor- (TNF-) α), adhesion molecules (E-selectin, P-selectin, and intercellular adhesion molecule- (ICAM-) 1), and chemokines (chemokine (C-C motif) ligand (CCL)2, CCL3, CCL4, and C-X-C motif chemokine (CXCL)10) were assessed using a Luminex multiplexing technology. Associations between concentrations of inflammatory biomarkers and continuous variables of heart rate variability and cardiac vagal tone were estimated using multivariable linear regression adjusting for age, sex, disease duration, and smoking. Results. Participants with the presence of cardiovascular autonomic neuropathy had higher systemic levels of IL-1α, IL-4, CCL2, and E-selectin than those without cardiovascular autonomic neuropathy. IL-1α, IL-4, IL-12, TNF-α, and E-selectin were inversely associated with both sympathetic and parasympathetic heart rate variability measures (p>0.01). Discussion. Our results show that several pro- and anti-inflammatory factors, believed to be involved in the progression of diabetic polyneuropathy, are associated with cardiovascular autonomic neuropathy, suggesting that these factors may also contribute to the pathogenesis of cardiovascular autonomic neuropathy. Our findings emphasize the importance of the neuroimmune regulatory system in the pathogenesis of neuropathy in type 1 diabetes.

scholarly journals Leukotriene Pathway Activation Associates with Poor Glycemic Control and with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Daniele P. Santos-Bezerra ◽  
Luciano R. Filgueiras ◽  
Maria Beatriz Monteiro ◽  
Sharon N. Admoni ◽  
Ricardo V. Perez ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Autonomic Neuropathy ◽  
Diabetes Complications ◽  
Mononuclear Cells ◽  
Quantitative Polymerase Chain Reaction ◽  
Microvascular Complications ◽  
Cardiovascular Autonomic Neuropathy ◽  
Peripheral Blood Mononuclear ◽  
The Status

Background and Aims. Since hyperglycemia promotes inflammation by different pathways and inflammation participates in the development of chronic diabetes complications, we investigated the association between the leukotriene (LT) pathway and microvascular diabetes complications. Methods and Results. Quantitative polymerase chain reaction was employed to quantify the expression of ALOX5 (encodes 5-lipoxygenase), LTB4R (encodes one of the LTB4 receptors), and MYD88 in peripheral blood mononuclear cells from 164 type 1 diabetes (T1D) individuals presenting or not diabetes kidney disease, retinopathy, peripheral neuropathy, and cardiovascular autonomic neuropathy (CAN); 26 nondiabetic subjects were included as controls. LTB4 plasmatic concentrations were also evaluated. The expression of LTB4R was significantly higher in T1D individuals than in controls. T1D individuals with microvascular complications presented lower MYD88 mRNA expression when compared to those without microvascular complications. Higher LTB4 concentrations were found in individuals with CAN versus without CAN. The observation of two distinct subgroups of T1D individuals in the correlation analyses motivated us to evaluate the characteristics of each one of these groups separately. The group presenting higher expression of ALOX5 and of LTB4R also presented higher values of HbA1C, of fructosamine, and of plasmatic LTB4. Conclusion. In the diabetes setting, the LT pathway is not only activated by hyperglycemia but is also modulated by the status of the autonomic nervous system.

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