scholarly journals Retinal Nerve Fiber Layer Loss in Patients With Type 2 Diabetes and Diabetic Neuropathy

Diabetes Care ◽  
2016 ◽  
Vol 39 (5) ◽  
pp. e69-e70 ◽  
Author(s):  
Hae-Young Lopilly Park ◽  
Juyoung Shin ◽  
Jae Hyung Lee ◽  
Chan Kee Park
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Neuropathy ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Nerve Fiber

scholarly journals Retinal Nerve Fiber Layer Decrease during Glycemic Control in Type 2 Diabetes

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Masahiko Sugimoto ◽  
Mikio Sasoh ◽  
Masashi Ido ◽  
Chisato Narushima ◽  
Yukitaka Uji
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Glycosylated Hemoglobin ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Retinal Nerve Fiber

Purpose. To assess an effect of glycemic control on retinal nerve fiber layer (RNFL) in type 2 diabetes mellitus.Methods. Thirty-eight eyes of 38 patients with type 2 diabetes undergoing blood glucose regulation were enrolled. All patients were examined at (1) initial visit, (2) 1 month, (3) 2 months, and (4) 4-month after the initial examination. On each occasion, glycosylated hemoglobin (HbA1c) levels and optical coherence tomography (OCT) scanning for RNFL thickness were evaluated. 360 degree circular OCT scans with a diameter of 3.4 mm centered on the optic disc were performed.Results. Significant RNFL decrease was seen in the superior area between initial and 4 months examination (). The relationship between the changes in HbA1c and the changes in RNFL thickness was observed in superior, temporal, and inferior area () at 4 months.Conclusions. This study suggests that the glycemic control affects RNFL within 4 months.

Retinal Nerve Fiber Layer Loss Is Associated with Urinary Albumin Excretion in Patients with Type 2 Diabetes

Ophthalmology ◽  
2015 ◽  
Vol 122 (5) ◽  
pp. 976-981 ◽  
Author(s):  
Jin A. Choi ◽  
Sun-Hee Ko ◽  
Yi Ryeung Park ◽  
Dong-Hyun Jee ◽  
Seung-Hyun Ko ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Urinary Albumin Excretion ◽  
Urinary Albumin ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Albumin Excretion ◽  
Retinal Nerve Fiber

scholarly journals Effects of prolonged type 2 diabetes on changes in peripapillary retinal nerve fiber layer thickness in diabetic eyes without clinical diabetic retinopathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Min-Woo Lee ◽  
Hyung-Bin Lim ◽  
Min-Su Kim ◽  
Gi-Seok Park ◽  
Ki-Yup Nam ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Reduction Rate ◽  
Control Group ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Nerve Fiber

AbstractTo identify the effects of prolonged type 2 diabetes (T2DM) on changes in peripapillary retinal nerve fiber layer (pRNFL) thickness in patients without clinical diabetic retinopathy. Subjects were divided into two groups: controls and patients with T2DM (DM group). After the initial visits, the pRNFL thicknesses were measured three more times at 1-year intervals. Subgroup analyses were performed in patients with T2DM duration ≥ 10 years. The mean pRNFL thickness at each visit was 95.8 ± 8.1, 95.4 ± 8.3, 94.9 ± 8.1, and 94.5 ± 8.3 μm in the control group (P = 0.138) (n = 55); and 93.4 ± 9.1, 92.1 ± 9.3, 90.9 ± 9.3, and 89.5 ± 9.2 μm in the DM group (P < 0.001) (n = 85). The estimated rate of reduction in mean pRNFL thickness was − 0.45 μm/year in the control group and − 1.34 μm/year in the DM group, respectively. In the DM group, the BCVA and HbA1c (both P = 0.001) were significant factors associated with pRNFL reduction. In patients with T2DM duration ≥ 10 years, the estimated pRNFL reduction rate was − 1.61 μm/year, and hypertension was a significant factor affecting the pRNFL reduction (P = 0.046). We confirmed rapid pRNFL reduction over time in T2DM, and the reduction rate was higher in patients with T2DM ≥ 10 years. Additionally, BCVA and HbA1c levels were significantly associated with the change in pRNFL thickness in T2DM patients.

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