scholarly journals Cardiovascular Risk Factor Targets and Cardiovascular Disease Event Risk in Diabetes: A Pooling Project of the Atherosclerosis Risk in Communities Study, Multi-Ethnic Study of Atherosclerosis, and Jackson Heart Study

Diabetes Care ◽  
2016 ◽  
Vol 39 (5) ◽  
pp. 668-676 ◽  
Author(s):  
Nathan D. Wong ◽  
Yanglu Zhao ◽  
Rohini Patel ◽  
Christopher Patao ◽  
Shaista Malik ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factor ◽  
Atherosclerosis Risk In Communities ◽  
Ethnic Study ◽  
Event Risk ◽  
Heart Study ◽  
Atherosclerosis Risk ◽  
Cardiovascular Disease Event

Type a coronary-prone behavior pattern and cardiovascular risk factor variables in children and adolescents: The Bogalusa Heart Study

1982 ◽  
Vol 35 (8) ◽  
pp. 613-621 ◽  
Author(s):  
Saundra Macd. Hunter ◽  
Thomas M. Wolf ◽  
Monny C. Sklov ◽  
Larry S. Webber ◽  
Rebecca M. Watson ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cardiovascular Risk ◽  
Children And Adolescents ◽  
Cardiovascular Risk Factor ◽  
Behavior Pattern ◽  
Type A ◽  
Bogalusa Heart Study ◽  
Heart Study ◽  
Coronary Prone Behavior

scholarly journals Lipoprotein(a): the underutilized risk factor for cardiovascular disease

2019 ◽  
Vol 2019 (2) ◽  
Author(s):  
T Z Khan ◽  
S R Bornstein ◽  
M Barbir
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factor ◽  
Cardiovascular Events ◽  
Adverse Outcomes ◽  
Lipoprotein A ◽  
Diagnosis And Management ◽  
Randomised Controlled

Raised lipoprotein(a) [Lp(a)] is an important independent cardiovascular risk factor and predictor of adverse outcomes. Challenges remain with regards to the screening, diagnosis and management of this condition. Although further prospective randomised controlled data is required, there is growing evidence suggesting that lowering Lp(a) may reduce the risk of cardiovascular events and ameliorate symptoms.

Abstract P368: Risk Factor Interventions are Effective for Preventing Cardiovascular Events in HIV-Infected Patients on Antiretroviral Therapy: A Systematic Review and Meta-analysis

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Chidozie Nduka ◽  
Kandala Ngianga-Bakwin ◽  
Gaurav Suri ◽  
Saverio Stranges
Keyword(s):  
Systematic Review ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factor ◽  
Cardiovascular Events ◽  
Antiretroviral Treatment ◽  
Clinical Effectiveness ◽  
Lipid Lowering ◽  
Hiv Positive

Introduction: The declining rate of HIV-related deaths has become rather slow in recent times, largely because of the rising incidence of cardiovascular events associated with the disease and its long-term treatment with anti-retroviral drugs. While conclusive evidences support the effectiveness of cardiovascular risk factor interventions in the general population, there is a dearth of such evidence of clinical effectiveness in certain high-risk subgroups, particularly HIV-infected patients on antiretroviral treatment. Objective: To evaluate the clinical effectiveness of risk factor interventions in preventing cardiovascular disease in HIV-positive patients on antiretroviral treatment (ART) and summarize the effect size. Design and methods: Systematic review of randomized controlled trials investigating the effects of interventions in modifying ART-associated risk factors for cardiovascular disease. Trials were eligible for inclusion if they were published in the last 12 years [2000 to June 2012] and participants were HIV-positive, on ART and having more than one ART-associated cardiovascular risk factor. Results: In total, 2,071 HIV-positive participants from 10 randomized trials were included in the review. The interventions evaluated comprised lifestyle modification, lipid-lowering treatment and smoking cessation. Overall, the main results showed significant improvements in total cholesterol [P<0.0001], LDL cholesterol [P<0.0001], HDL cholesterol [P<0.002], triglycerides [P<0.001], apolipoprotein B levels [P=0.036], adiposity [<0.001], anthropometry [P<0.001], insulin sensitivity [P<0.05], HbA1c levels [P<0.001], FBG levels [P=0.017], adiponectin levels [P<0.05], dietary intake [P<0.001], smoking abstinence [P<0.0001] and Framingham score [P=0.03]. The results also showed improvements in systolic [from 145.6±14.5 mmHg to 122.8±5.2 mmHg] and diastolic blood pressure [from 84.7±1.7 mmHg to 80.1±3.8 mmHg]; however, there was no improvement in carotid intima-media thickness [P=0.61] or inflammatory biomarkers [P=0.973 to 0.110]. Conclusion: In conclusion, this review presents evidence suggesting that cardiovascular risk factor interventions are effective in HIV-infected persons on ART. However, cardiovascular screening programs targeting people living with HIV and primary studies assessing the effectiveness (clinical and cost) of multiple risk factor interventions in this sub-group are needed.

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