scholarly journals Different Associations of Diabetes With β-Cell Dysfunction and Insulin Resistance Among Obese and Nonobese Chinese Women With Prior Gestational Diabetes Mellitus

Diabetes Care ◽  
2014 ◽  
Vol 37 (9) ◽  
pp. 2533-2539 ◽  
Author(s):  
Weiqin Li ◽  
Shuang Zhang ◽  
Huikun Liu ◽  
Leishen Wang ◽  
Cuiping Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Chinese Women ◽  
Β Cell ◽  
Cell Dysfunction

Association Between a Melatonin Receptor 1B Genetic Polymorphism and Its Protein Expression in Gestational Diabetes Mellitus

2018 ◽  
Vol 26 (10) ◽  
pp. 1382-1388 ◽  
Author(s):  
Chao Li ◽  
Yubin Zhou ◽  
Binglong Qiao ◽  
Lin Xu ◽  
Yan Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Genetic Polymorphism ◽  
Gestational Diabetes ◽  
Protein Expression ◽  
Gestational Diabetes Mellitus ◽  
Chinese Women ◽  
Han Chinese ◽  
Melatonin Receptor ◽  
Melatonin Receptor 1B

Aims: This study was conducted to investigate the relationship between a genetic polymorphism and the expression of melatonin receptor 1B (MTNR1B) in the placenta of Han Chinese women with gestational diabetes mellitus (GDM). Methods: In this study, 215 patients with GDM and 243 healthy controls were genotyped using direct sequencing for the MTNR1B single-nucleotide polymorphism rs10830963. The expression of MTNR1B in placenta was detected by immunohistochemistry and Western blotting. The association of rs10830963 with the expression of MTNR1B, plasma glucose, and insulin levels as well as blood lipid levels was investigated. Results: The genotype and allele frequencies of rs10830963 were significantly different between women with GDM and controls ( P < .05). Fasting blood glucose, fasting insulin, and homeostasis model assessment for insulin resistance in women with GDM with the GG and GC genotypes were significantly higher than those with the CC genotype ( P < .05). The expression level of MTNR1B in placenta was significantly higher in the GDM group than in the control group ( P < .05). The expression of MTNR1B was significantly higher in all participants with the GG and GC genotypes (1.31 [0.74]) than in pregnant women with the CC genotype (0.92 [0.52], P < .05). Conclusions: The genetic polymorphism rs10830963 in MTNR1B and its protein expression levels in placenta are associated with an increased risk of developing GDM. Furthermore, rs10830963 may tag a molecular mechanism leading to insulin resistance in Han Chinese women with GDM.

scholarly journals Lower iodine storage in the placenta is associated with gestational diabetes mellitus

BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Kristof Y. Neven ◽  
Bianca Cox ◽  
Charlotte Cosemans ◽  
Wilfried Gyselaers ◽  
Joris Penders ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Cord Blood ◽  
Plasma Insulin ◽  
Cell Activity ◽  
Insulin Concentration ◽  
Β Cell ◽  
Plasma Insulin Concentration

Abstract Background The micronutrient iodine is essential for a healthy intrauterine environment and is required for optimal fetal growth and neurodevelopment. Evidence linking urinary iodine concentrations, which mainly reflects short-term iodine intake, to gestational diabetes mellitus (GDM) is inconclusive. Although the placental concentrations would better reflect the long-term gestational iodine status, no studies to date have investigated the association between the placental iodine load and the risk at GDM. Moreover, evidence is lacking whether placental iodine could play a role in biomarkers of insulin resistance and β-cell activity. Methods We assessed the incidence of GDM between weeks 24 and 28 of gestation for 471 mother-neonate pairs from the ENVIRONAGE birth cohort. In placentas, we determined the iodine concentrations. In maternal and cord blood, we measured the insulin concentrations, the Homeostasis Model Assessment (HOMA) for insulin resistance (IR) index, and β-cell activity. Logistic regression was used to estimate the odds ratios (OR) of GDM, and the population attributable factor (PAF) was calculated. Generalized linear models estimated the changes in insulin, HOMA-IR, and β-cell activity for a 5 μg/kg increase in placental iodine. Results Higher placental iodine concentrations decreased the risk at GDM (OR = 0.82; 95%CI 0.72 to 0.93; p = 0.003). According to the PAF, 54.2% (95%CI 11.4 to 82.3%; p = 0.0006) of the GDM cases could be prevented if the mothers of the lowest tertile of placental iodine would have placental iodine levels as those belonging to the highest tertile. In cord blood, the plasma insulin concentration was inversely associated with the placental iodine load (β = − 4.8%; 95%CI − 8.9 to − 0.6%; p = 0.026). Conclusions Higher concentrations of placental iodine are linked with a lower incidence of GDM. Moreover, a lower placental iodine load is associated with an altered plasma insulin concentration, HOMA-IR index, and β-cell activity. These findings postulate that a mild-to-moderate iodine deficiency could be linked with subclinical and early-onset alterations in the normal insulin homeostasis in healthy pregnant women. Nevertheless, the functional link between gestational iodine status and GDM warrants further research.

scholarly journals Elevated Medium-Chain Acylcarnitines Are Associated With Gestational Diabetes Mellitus and Early Progression to Type 2 Diabetes and Induce Pancreatic β-Cell Dysfunction

Diabetes ◽  
2018 ◽  
Vol 67 (5) ◽  
pp. 885-897 ◽  
Author(s):  
Battsetseg Batchuluun ◽  
Dana Al Rijjal ◽  
Kacey J. Prentice ◽  
Judith A. Eversley ◽  
Elena Burdett ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Medium Chain ◽  
Cell Dysfunction ◽  
Early Progression

scholarly journals High Calorie Intake Is Associated With Worsening Insulin Resistance and β-Cell Function in Hispanic Women After Gestational Diabetes Mellitus

Diabetes Care ◽  
2014 ◽  
Vol 37 (12) ◽  
pp. 3294-3300 ◽  
Author(s):  
Zhanghua Chen ◽  
Richard M. Watanabe ◽  
Daniel O. Stram ◽  
Thomas A. Buchanan ◽  
Anny H. Xiang
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Cell Function ◽  
Hispanic Women ◽  
Calorie Intake ◽  
Β Cell ◽  
Β Cell Function ◽  
High Calorie
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