scholarly journals A Low–Glycemic Index Meal and Bedtime Snack Prevents Postprandial Hyperglycemia and Associated Rises in Inflammatory Markers, Providing Protection From Early but Not Late Nocturnal Hypoglycemia Following Evening Exercise in Type 1 Diabetes

Diabetes Care ◽  
2014 ◽  
Vol 37 (7) ◽  
pp. 1845-1853 ◽  
Author(s):  
Matthew D. Campbell ◽  
Mark Walker ◽  
Michael I. Trenell ◽  
Emma J. Stevenson ◽  
Daniel Turner ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Index ◽  
Inflammatory Markers ◽  
Postprandial Hyperglycemia ◽  
Nocturnal Hypoglycemia ◽  
Low Glycemic Index

scholarly journals Influence of and Optimal Insulin Therapy for a Low-Glycemic Index Meal in Children With Type 1 Diabetes Receiving Intensive Insulin Therapy

Diabetes Care ◽  
2008 ◽  
Vol 31 (8) ◽  
pp. 1485-1490 ◽  
Author(s):  
R. L. Ryan ◽  
B. R. King ◽  
D. G. Anderson ◽  
J. R. Attia ◽  
C. E. Collins ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Therapy ◽  
Intensive Insulin Therapy ◽  
Glycemic Index ◽  
Low Glycemic Index

scholarly journals Effect of low-glycemic-index dietary advice on dietary quality and food choice in children with type 1 diabetes

2003 ◽  
Vol 77 (1) ◽  
pp. 83-90 ◽  
Author(s):  
Heather R Gilbertson ◽  
Anne W Thorburn ◽  
Jennie C Brand-Miller ◽  
Patty Chondros ◽  
George A Werther
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Index ◽  
Food Choice ◽  
Dietary Quality ◽  
Dietary Advice ◽  
Low Glycemic Index

scholarly journals Comparison of appetite responses to high– and low–glycemic index postexercise meals under matched insulinemia and fiber in type 1 diabetes

2014 ◽  
Vol 101 (3) ◽  
pp. 478-486 ◽  
Author(s):  
Matthew D Campbell ◽  
Javier T Gonzalez ◽  
Penny LS Rumbold ◽  
Mark Walker ◽  
James A Shaw ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Index ◽  
Low Glycemic Index

scholarly journals The Effect of Flexible Low Glycemic Index Dietary Advice Versus Measured Carbohydrate Exchange Diets on Glycemic Control in Children With Type 1 Diabetes

Diabetes Care ◽  
2001 ◽  
Vol 24 (7) ◽  
pp. 1137-1143 ◽  
Author(s):  
H. R. Gilbertson ◽  
J. C. Brand-Miller ◽  
A. W. Thorburn ◽  
S. Evans ◽  
P. Chondros ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Glycemic Index ◽  
Dietary Advice ◽  
Low Glycemic Index

scholarly journals Super Bolus – A Remedy for A High Glycemic Index Meal in Children With Type 1 Diabetes on Insulin Pump Therapy?: Study Protocol for a Randomised Controlled Trial.

2020 ◽  
Author(s):  
Emilia Kowalczyk ◽  
Katarzyna Dżygało ◽  
Agnieszka Szypowska
Keyword(s):  
Type 1 Diabetes ◽  
Glucose Level ◽  
Glycemic Index ◽  
Insulin Dose ◽  
Postprandial Hyperglycemia ◽  
Insulin Pump Therapy ◽  
Prandial Insulin ◽  
In Silico Studies ◽  
High Glycemic Index

Abstract Background: Postprandial hyperglycemia (PPH) is common clinical problem among patients with type 1 diabetes (T1D), especially in relation to high glycemic index (h-GI) meals. The main problem are high, sharp glycemic spikes with following hypoglycemia after h-GI meal consumption. There is lack of effective and satisfactory solutions concerning insulin dose adjustment to cover the h-GI meal. The goal of this research is to find out whether a Super Bolus is an effective strategy to prevent postprandial hyperglycemia and late hypoglycemia after h-GI meal in comparison to the normal bolus.Methods: A total of 72 children aged 10-18 years with T1D for at least 1 year, treated with continuous subcutaneous insulin infusion for more than 3 months will be enrolled in a double-blind, randomized, cross-over clinical trial. Participants will receive the prandial insulin bolus for h-GI breakfast in the form of Super Bolus and as Normal Bolus another day. The primary outcome measure will be the glucose level 90 minutes after administration the prandial bolus. The secondary endpoints will refer to glucose level 30, 60, 120, 150, 180 minutes postprandially; the area under the blood glucose curve within 180 min postprandially; the peak glucose and time to peak glucose level; the glycemic rise, mean amplitude of glycemic excursion, time in postprandial glucose range and the number of hypoglycemia episodes.Discussion: There is a lack of clinical studies concerning this kind of bolus. Available literature refers only to in-silico studies and case reports. The Super Bolus was defined as a prandial insulin dose increased by 50% in comparison to the dose calculated based on individualized patient’s Insulin-Carbohydrate Ratio (ICR) and simultaneous suspension of the basal insulin for 2 hours. The comprehensive and effective solution to this frequent clinical difficulty of PPH after h-GI meals has not been found yet. The problem is known and important but the presented solution innovatory and easy to apply in every-day life.Trial registration: The trial was registered at the ClinicalTrials.gov prior to the inclusion of the first patient, 15 July 2019 on registration number: NCT04019821.

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