Closed-Loop Artificial Pancreas Systems: Physiological Input to Enhance Next-Generation Devices

OBJECTIVE To analyze safety and efficacy of the DBLG1 hybrid closed-loop artificial pancreas system in patients with Type 1 Diabetes in real life conditions. METHODS Following a one-week run-in period with usual pump, 25 patients were provided with the commercial DBLG1 system. We present the results of Time-in-Range and HbA1c over a 6-month period. RESULTS The mean (SD;range) age of patients was 43 years (13.8; 25-72). At baseline, mean HbA1c and TIR 70-180mg/dL were respectively 7.9% (0.93; 5.6- 8.5) [63mmol/mol (10; 38-69)] and 53% (16.4;21-85). One patient stopped using the system after 2 months. At 6-month, mean HbA1c decreased to 7.1% [54mmol/mol] (p<0.001) and TIR 70-180mg/dL increased to 69.7% (p<0.0001). TIR<70mg/dL decreased from 2.4 to 1.3% (p=0.03). TIR<54mg/dL decreased from 0.32 to 0.24% (p=0.42). No serious adverse event was reported during the study. CONCLUSION The DBLG1 System confirms its ability to significantly improve glycemic control in real life conditions, without serious adverse events.

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Future Gravity Mission Concepts for Sustained Observation of Mass Transport in the Earth System

10.5194/egusphere-egu21-9447 ◽

2021 ◽

Author(s):

Roland Pail

Keyword(s):

Mass Transport ◽

Closed Loop ◽

Cold Atom ◽

Radial Component ◽

Transport Processes ◽

Single Pair ◽

Earth System ◽

Next Generation ◽

The Earth ◽

Gravity Mission

Next Generation Gravity Missions are expected to enhance our knowledge of mass transport processes in the Earth system, establishing their products applicable to new scientific fields and serving societal needs. Compared to the current situation (GRACE Follow-On), a significant step forward to increase spatial and temporal resolution can only be achieved by new mission concepts, complemented by improved instrumentation and tailored processing strategies.In extensive numerical closed-loop mission simulations studies, different mission concepts have been studied in detail, with emphasis on orbit design and resulting spatial-temporal ground track pattern, enhances processing and parameterization strategies, and improved post-processing/filtering strategies. Promising candidates for a next-generation gravity mission are double-pair and multi-pair constellations of GRACE/GRACE-FO-type satellites, as they are currently jointly studied by ESA and NASA. An alternative concept is high-precision ranging between high- and low-flying satellites. Since such a constellation observes mainly the radial component of gravity-induced orbit perturbations, the error structure is close to isotropic, which significantly reduces artefacts of along-track ranging formations. This high-low concept was proposed as ESA Earth Explorer 10 mission MOBILE and is currently further studies under the name MARVEL by the French space agency. Additionally, we evaluate the potential of a hybridization of electro-static and cold-atom accelerometers in order to improve the accelerometer performance in the low-frequency range.In this contribution, based on full-fledged numerical closed-loop simulations with realistic error assumptions regarding their key payload, different mission constellations (in-line single-pair, Bender double-pair, multi-pairs, precise high-low tracking) are assessed and compared. Their overall performance, dealiasing potential, and recovery performance of short-periodic gravity signals are analyzed, in view of their capabilities to retrieve gravity field information with short latencies to be used for societally relevant service applications, such as water management, groundwater monitoring, and forecasting of droughts and floods.

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Hardware and Software Implementation of an Artificial Pancreas System on a Mobile Device

International Journal of Handheld Computing Research ◽

10.4018/ijhcr.2017010102 ◽

2017 ◽

Vol 8 (1) ◽

pp. 14-28

Author(s):

Caterina Lazaro ◽

Erdal Oruklu ◽

Mert Sevil ◽

Kamuran Turksoy ◽

Ali Cinar

Keyword(s):

Data Storage ◽

Mobile Device ◽

Closed Loop ◽

Insulin Pump ◽

Artificial Pancreas ◽

Vital Signs ◽

Application Development ◽

Loop Control ◽

Remote Server ◽

Fusion Data

In this work, an artificial pancreas (AP) system, implemented on a mobile device is described. The proposed AP platform integrates hardware (insulin pump, glucose monitor, various sensors for vital signs and physical activities) and software (closed-loop control algorithm, sensor fusion, data storage and remote server access) components via smartphone that is running a dedicated Operating System designed for AP systems. Interfacing with this OS and custom application development steps are presented. Closed loop operation is demonstrated with case studies.

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