scholarly journals Very-Low-Calorie Diet Increases Myocardial Triglyceride Content and Decreases Diastolic Left Ventricular Function in Type 2 Diabetes With Cardiac Complications: Table 1

Diabetes Care ◽  
2013 ◽  
Vol 37 (1) ◽  
pp. e1-e2 ◽  
Author(s):  
Jacqueline T. Jonker ◽  
Roxana Djaberi ◽  
Linda D. van Schinkel ◽  
Sebastiaan Hammer ◽  
Mieke T.J. Bus ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Left Ventricular ◽  
Cardiac Complications ◽  
Very Low Calorie Diet ◽  
Low Calorie Diet ◽  
Diastolic Left Ventricular Function ◽  
Calorie Diet ◽  
Triglyceride Content ◽  
Myocardial Triglyceride Content

scholarly journals Serum Concentrations and Subcutaneous Adipose Tissue mRNA Expression of Omentin in Morbid Obesity and Type 2 Diabetes Mellitus: the Effect of Very-Low-Calorie Diet, Physical Activity and Laparoscopic Sleeve Gastrectomy

2014 ◽  
pp. 207-218 ◽  
Author(s):  
M. URBANOVÁ ◽  
I. DOSTÁLOVÁ ◽  
P. TRACHTA ◽  
J. DRÁPALOVÁ ◽  
P. KAVÁLKOVÁ ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mrna Expression ◽  
Subcutaneous Adipose Tissue ◽  
Very Low Calorie Diet ◽  
Low Calorie Diet ◽  
Calorie Diet ◽  
Subcutaneous Adipose

Omentin is a novel adipokine with insulin-sensitizing effects expressed predominantly in visceral fat. We investigated serum omentin levels and its mRNA expression in subcutaneous adipose tissue (SCAT) of 11 women with type 2 diabetes mellitus (T2DM), 37 obese non-diabetic women (OB) and 26 healthy lean women (C) before and after various weight loss interventions: 2-week very-low-calorie diet (VLCD), 3-month regular exercise and laparoscopic sleeve gastrectomy (LSG). At baseline, both T2DM and OB groups had decreased serum omentin concentrations compared with C group while omentin mRNA expression in SCAT did not significantly differ among the groups. Neither VLCD nor exercise significantly affected serum omentin concentrations and its mRNA expression in SCAT of OB or T2DM group. LSG significantly increased serum omentin levels in OB group. In contrast, omentin mRNA expression in SCAT was significantly reduced after LSG. Baseline fasting serum omentin levels in a combined group of the studied subjects (C, OB, T2DM) negatively correlated with BMI, CRP, insulin, LDL-cholesterol, triglycerides and leptin and were positively related to HDL-cholesterol. Reduced circulating omentin levels could play a role in the etiopathogenesis of obesity and T2DM. The increase in circulating omentin levels and the decrease in omentin mRNA expression in SCAT of obese women after LSG might contribute to surgery-induced metabolic improvements and sustained reduction of body weight.

scholarly journals Treatment of Type 2 Diabetes in Childhood Using a Very-Low-Calorie Diet

Diabetes Care ◽  
2004 ◽  
Vol 27 (2) ◽  
pp. 348-353 ◽  
Author(s):  
S. M. Willi ◽  
K. Martin ◽  
F. M. Datko ◽  
B. P. Brant
Keyword(s):  
Type 2 Diabetes ◽  
Very Low Calorie Diet ◽  
Low Calorie ◽  
Diabetes In Childhood ◽  
Low Calorie Diet ◽  
Calorie Diet

scholarly journals The Effect of Very-Low-Calorie Diet on mRNA Expression of Inflammation-Related Genes in Subcutaneous Adipose Tissue and Peripheral Monocytes of Obese Patients with Type 2 Diabetes Mellitus

2011 ◽  
Vol 96 (4) ◽  
pp. E606-E613 ◽  
Author(s):  
M. Mraz ◽  
Z. Lacinova ◽  
J. Drapalova ◽  
D. Haluzikova ◽  
A. Horinek ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Mrna Expression ◽  
Obese Patients ◽  
Very Low Calorie Diet ◽  
Low Calorie Diet ◽  
Calorie Diet ◽  
Proinflammatory Factors

Abstract Context: Low-grade inflammation links obesity, type 2 diabetes mellitus (T2DM), and cardiovascular diseases. Objective: To explore the expression profile of genes involved in inflammatory pathways in adipose tissue and peripheral monocytes (PM) of obese patients with and without T2DM at baseline and after dietary intervention. Design: Two-week intervention study with very-low-calorie diet (VLCD). Setting: University hospital. Patients: Twelve obese females with T2DM, 8 obese nondiabetic females (OB) and 15 healthy age-matched females. Intervention: Two weeks of VLCD (2500 kJ/d). Main Outcome Measures: Metabolic parameters, circulating cytokines, hormones, and mRNA expression of 39 genes in sc adipose tissue (SCAT) and PM. Results: Both T2DM and OB group had significantly increased serum concentrations of circulating proinflammatory factors (C-reactive protein, TNFα, IL-6, IL-8), mRNA expression of macrophage antigen CD68 and proinflammatory chemokines (CCL-2, -3, -7, -8, -17, -22) in SCAT and complementary chemokine receptors (CCR-1, -2, -3, -5) and other proinflammatory receptors (toll-like receptor 2 and 4, TNF receptor superfamily 1A and 1B, IL-6R) in PM, with OB group showing less pronounced chemoattracting and proinflammatory profile compared to T2DM group. In T2DM patients VLCD decreased body weight, improved metabolic profile, and decreased mRNA expression of up-regulated CCRs in PM and chemokines [CCL 8, chemokine (C-X-C motif) ligand 10] in SCAT. VLCD markedly increased mRNA expression of T-lymphocyte attracting chemokine CCL-17 in SCAT. Conclusion: Obese patients with and without T2DM have increased mRNA expression of chemotactic and proinflammatory factors in SCAT and expression of corresponding receptors in PM. Two weeks of VLCD significantly improved this profile in T2DM patients.

scholarly journals Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes

2018 ◽  
Vol 27 (1) ◽  
pp. 210-217.e3 ◽  
Author(s):  
Rachel J. Perry ◽  
Liang Peng ◽  
Gary W. Cline ◽  
Yongliang Wang ◽  
Aviva Rabin-Court ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Rat Model ◽  
Very Low Calorie Diet ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet
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