scholarly journals The Association of Skin Intrinsic Fluorescence With Type 1 Diabetes Complications in the DCCT/EDIC Study

Diabetes Care ◽  
2013 ◽  
Vol 36 (10) ◽  
pp. 3146-3153 ◽  
Author(s):  
T. J. Orchard ◽  
T. J. Lyons ◽  
P. A. Cleary ◽  
B. H. Braffett ◽  
J. Maynard ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetes Complications ◽  
Intrinsic Fluorescence ◽  
Skin Intrinsic Fluorescence

scholarly journals Epigenetics of skin intrinsic florescence

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Jiamin Guo ◽  
Andrew Paterson ◽  
Delnaz Roshandel
Keyword(s):  
Dna Methylation ◽  
Type 1 Diabetes ◽  
Intrinsic Fluorescence ◽  
P Value ◽  
Haemoglobin A1c ◽  
Linear Regression Models ◽  
Significance Level ◽  
Cpg Site ◽  
Skin Intrinsic Fluorescence

Introduction & Objective: Cumulated advanced glycation end products (AGEs) in the bloodstream and tissues contribute to the pathogenesis of diabetes complications. The skin intrinsic fluorescence (SIF) is a non-invasive measurement of dermal AGEs level using spectrometer, and it can be used as a biomarker in AGEs-related diseases. Previously, specific epigenomic factor has been found to be associated with haemoglobin A1c (HbA1c). HbA1c is a type of glycated haemoglobin – the HbA1c test measures the average glycemic control over the period of 3 months. However, the effect of epigenetic factors on the level of AGEs in the skin remains unknown. We hypothesize that some cytosine-guanine dinucleotides (CpGs) are associated with SIF. An epigenome-wide associations study (EWAS) was performed to identify CpG sites associated with SIF in people with type 1 diabetes. Methods: 499 people with type 1 diabetes that have both methylation and SIF from the Diabetes Control Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study were included. We fit linear regression models for SIF with each CpG site one at a time. The epigenome-wide significance level (p=5e-8) was applied. Then the result is compared with the null hypothesis where CpGs are not associated with SIF to check the inflation. In order to check the assumptions of the multiple linear models at a single CpG, we use diagnostic plots. Results: We did not identify a specific CpG that is significantly associated with neither skin intrinsic fluorescence 1 (SIF1) nor skin intrinsic fluorescence 12 (SIF 12).The CpG site with strongest effect is cg06538183 ([SE] -2.73 [0.61], p = 8.72e-6) on SIF1 and cg12871967 ([SE] 2.52, 0.53, p = 2.71e-6) on SIF12. Conclusion: We did not find any specific CpG that was significantly associated with either SIF 1 or SIF12. In general, the result suggests that DNA methylation does not impact the accumulation of AGEs in skin cells. DNA methylation data has a unique pattern of distribution that drives the non-uniform distribution of the p-values. The group of 275,301 CpGs that have means above the median and standard deviations below the median has the expected uniform p-value distribution.

scholarly journals Caffeine Consumption Contributes to Skin Intrinsic Fluorescence in Type 1 Diabetes

2015 ◽  
Vol 17 (10) ◽  
pp. 726-734 ◽  
Author(s):  
Karen M. Eny ◽  
Trevor J. Orchard ◽  
Rachel Grace Miller ◽  
John Maynard ◽  
Denis M. Grant ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Intrinsic Fluorescence ◽  
Caffeine Consumption ◽  
Skin Intrinsic Fluorescence

1656-P: Skin Intrinsic Fluorescence (SIF) Scores and Mortality Risk in Type 1 Diabetes (T1D)

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1656-P
Author(s):  
ERIN L. TOMASZEWSKI ◽  
TREVOR J. ORCHARD ◽  
MARQUIS S. HAWKINS ◽  
THOMAS SONGER ◽  
JOHN D. MAYNARD ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Mortality Risk ◽  
Intrinsic Fluorescence ◽  
Skin Intrinsic Fluorescence

scholarly journals Skin Intrinsic Fluorescence Correlates With Autonomic and Distal Symmetrical Polyneuropathy in Individuals With Type 1 Diabetes

Diabetes Care ◽  
2011 ◽  
Vol 34 (4) ◽  
pp. 1000-1005 ◽  
Author(s):  
B. N. Conway ◽  
V. R. Aroda ◽  
J. D. Maynard ◽  
N. Matter ◽  
S. Fernandez ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Intrinsic Fluorescence ◽  
Distal Symmetrical Polyneuropathy ◽  
Skin Intrinsic Fluorescence

scholarly journals Skin Intrinsic Fluorescence Is Associated With Coronary Artery Disease in Individuals With Long Duration of Type 1 Diabetes

Diabetes Care ◽  
2012 ◽  
Vol 35 (11) ◽  
pp. 2331-2336 ◽  
Author(s):  
B. N. Conway ◽  
V. R. Aroda ◽  
J. D. Maynard ◽  
N. Matter ◽  
S. Fernandez ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Intrinsic Fluorescence ◽  
Long Duration ◽  
Artery Disease ◽  
Skin Intrinsic Fluorescence

scholarly journals New Locus for Skin Intrinsic Fluorescence in Type 1 Diabetes Also Associated With Blood and Skin Glycated Proteins

Diabetes ◽  
2016 ◽  
Vol 65 (7) ◽  
pp. 2060-2071 ◽  
Author(s):  
Delnaz Roshandel ◽  
Ronald Klein ◽  
Barbara E.K. Klein ◽  
Bruce H.R. Wolffenbuttel ◽  
Melanie M. van der Klauw ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Intrinsic Fluorescence ◽  
Glycated Proteins ◽  
Skin Intrinsic Fluorescence

scholarly journals Predictors of Change in Skin Intrinsic Fluorescence in Type 1 Diabetes: The Epidemiology of Diabetes Complications study

2021 ◽  
pp. 193229682110143
Author(s):  
Erin L. Tomaszewski ◽  
Trevor J. Orchard ◽  
Marquis S. Hawkins ◽  
Rebecca B.N. Conway ◽  
Jeanine M. Buchanich ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetes Complications ◽  
Glycosylated Hemoglobin ◽  
Albumin Excretion Rate ◽  
Linear Regression Models ◽  
Score Change ◽  
Indirect Measures ◽  
Glycation End Products ◽  
Skin Intrinsic Fluorescence

Background Skin intrinsic fluorescent (SIF) scores are indirect measures of advanced glycation end-products (AGEs). SIF scores are cross-sectionally associated with type 1 diabetes (T1D) complications such as increased albumin excretion rate (AER), coronary artery calcification (CAC) and neuropathy. We assessed predictors of SIF score change in those with T1D. Methods Data from the 30-year longitudinal Epidemiology of Diabetes Complications (EDC) study of childhood-onset T1D were used to assess AGEs measured with a SIF score produced by the SCOUT DS® device. SIF scores were assessed twice in 83 participants: between 2007-08 and again between 2010-14. Regression analyses were used to assess independent predictors of SIF score change Results At baseline, mean age was 47.9 ± 6.9 years, diabetes duration was 36.7 ± 6.4 years, and median glycosylated hemoglobin (HbA1c) was 7.1 (interquartile range: 6.5, 8.5). During a mean follow-up of 5.2 ± 0.9 years, mean change in SIF score was 2.9 ± 2.8 arbitrary units. In multivariable linear regression models, log HbA1c ( P < 0.001), log estimated glomerular filtration rate (eGFR) ( P < 0.001), overt nephropathy (defined as AER ≥ 200 µg/min, P = 0.06), and multiple daily insulin shots/pump use (MDI) exposure years ( P = 0.02) were independent predictors of SIF score change. Conclusions Increases in SIF score over 5 years were related to increased glycemic levels and decreased kidney function (eGFR). MDI and glomerular damage were related to a decreased SIF score. This is one of the first studies with repeated SIF assessments in T1D and provides unique, albeit preliminary, insight about these associations.

Sign in / Sign up

Export Citation Format

Share Document