scholarly journals Systemic Oxidative Stress Is Associated With Lower Aerobic Capacity and Impaired Skeletal Muscle Energy Metabolism in Patients With Metabolic Syndrome

Diabetes Care ◽  
2013 ◽  
Vol 36 (5) ◽  
pp. 1341-1346 ◽  
Author(s):  
T. Yokota ◽  
S. Kinugawa ◽  
M. Yamato ◽  
K. Hirabayashi ◽  
T. Suga ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Metabolic Syndrome ◽  
Energy Metabolism ◽  
Aerobic Capacity ◽  
Systemic Oxidative Stress ◽  
Muscle Energy ◽  
Muscle Energy Metabolism

scholarly journals Pioglitazone improves whole-body aerobic capacity and skeletal muscle energy metabolism in patients with metabolic syndrome

2017 ◽  
Vol 8 (4) ◽  
pp. 535-541 ◽  
Author(s):  
Takashi Yokota ◽  
Shintaro Kinugawa ◽  
Kagami Hirabayashi ◽  
Tadashi Suga ◽  
Shingo Takada ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Metabolic Syndrome ◽  
Energy Metabolism ◽  
Aerobic Capacity ◽  
Whole Body ◽  
Muscle Energy ◽  
Muscle Energy Metabolism

Pioglitazone Improves Aerobic Capacity and Skeletal Muscle Energy Metabolism in Patients with Metabolic Syndrome

2016 ◽  
Vol 22 (9) ◽  
pp. S205 ◽  
Author(s):  
Takashi Yokota ◽  
Shintaro Kinugawa ◽  
Kagami Hirabayashi ◽  
Tadashi Suga ◽  
Shingo Takada ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Metabolic Syndrome ◽  
Energy Metabolism ◽  
Aerobic Capacity ◽  
Muscle Energy ◽  
Muscle Energy Metabolism

scholarly journals Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in heart failure patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Takashi Yokota ◽  
Shintaro Kinugawa ◽  
Kagami Hirabayashi ◽  
Mayumi Yamato ◽  
Shingo Takada ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Skeletal Muscle ◽  
Energy Metabolism ◽  
Aerobic Capacity ◽  
Plantar Flexion ◽  
Exercise Intolerance ◽  
Whole Body ◽  
Resonance Spectroscopy ◽  
Systemic Oxidative Stress

AbstractOxidative stress plays a role in the progression of chronic heart failure (CHF). We investigated whether systemic oxidative stress is linked to exercise intolerance and skeletal muscle abnormalities in patients with CHF. We recruited 30 males: 17 CHF patients, 13 healthy controls. All participants underwent blood testing, cardiopulmonary exercise testing, and magnetic resonance spectroscopy (MRS). The serum thiobarbituric acid reactive substances (TBARS; lipid peroxides) were significantly higher (5.1 ± 1.1 vs. 3.4 ± 0.7 μmol/L, p < 0.01) and the serum activities of superoxide dismutase (SOD), an antioxidant, were significantly lower (9.2 ± 7.1 vs. 29.4 ± 9.7 units/L, p < 0.01) in the CHF cohort versus the controls. The oxygen uptake (VO2) at both peak exercise and anaerobic threshold was significantly depressed in the CHF patients; the parameters of aerobic capacity were inversely correlated with serum TBARS and positively correlated with serum SOD activity. The phosphocreatine loss during plantar-flexion exercise and intramyocellular lipid content in the participants' leg muscle measured by 31phosphorus- and 1proton-MRS, respectively, were significantly elevated in the CHF patients, indicating abnormal intramuscular energy metabolism. Notably, the skeletal muscle abnormalities were related to the enhanced systemic oxidative stress. Our analyses revealed that systemic oxidative stress is related to lowered whole-body aerobic capacity and skeletal muscle dysfunction in CHF patients.

scholarly journals Swim Training Modulates Mouse Skeletal Muscle Energy Metabolism and Ameliorates Reduction in Grip Strength in a Mouse Model of Amyotrophic Lateral Sclerosis

2019 ◽  
Vol 20 (2) ◽  
pp. 233 ◽  
Author(s):  
Damian Jozef Flis ◽  
Katarzyna Dzik ◽  
Jan Jacek Kaczor ◽  
Karol Cieminski ◽  
Malgorzata Halon-Golabek ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Amyotrophic Lateral Sclerosis ◽  
Energy Metabolism ◽  
Muscle Strength ◽  
Grip Strength ◽  
Oxidative Stress Marker ◽  
Muscle Energy ◽  
Muscle Energy Metabolism ◽  
Lateral Sclerosis

Metabolic reprogramming in skeletal muscles in the human and animal models of amyotrophic lateral sclerosis (ALS) may be an important factor in the diseases progression. We hypothesized that swim training, a modulator of cellular metabolism via changes in muscle bioenergetics and oxidative stress, ameliorates the reduction in muscle strength in ALS mice. In this study, we used transgenic male mice with the G93A human SOD1 mutation B6SJL-Tg (SOD1G93A) 1Gur/J and wild type B6SJL (WT) mice. Mice were subjected to a grip strength test and isolated skeletal muscle mitochondria were used to perform high-resolution respirometry. Moreover, the activities of enzymes involved in the oxidative energy metabolism and total sulfhydryl groups (as an oxidative stress marker) were evaluated in skeletal muscle. ALS reduces muscle strength (−70% between 11 and 15 weeks, p < 0.05), modulates muscle metabolism through lowering citrate synthase (CS) (−30% vs. WT, p = 0.0007) and increasing cytochrome c oxidase and malate dehydrogenase activities, and elevates oxidative stress markers in skeletal muscle. Swim training slows the reduction in muscle strength (−5% between 11 and 15 weeks) and increases CS activity (+26% vs. ALS I, p = 0.0048). Our findings indicate that swim training is a modulator of skeletal muscle energy metabolism with concomitant improvement of skeletal muscle function in ALS mice.

scholarly journals Endospanin-2 enhances skeletal muscle energy metabolism and running endurance capacity

JCI Insight ◽  
2018 ◽  
Vol 3 (9) ◽  
Author(s):  
Steve Lancel ◽  
Matthijs K.C. Hesselink ◽  
Estelle Woldt ◽  
Yves Rouillé ◽  
Emilie Dorchies ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Energy Metabolism ◽  
Endurance Capacity ◽  
Muscle Energy ◽  
Muscle Energy Metabolism

Effects of the Anti-Migraine Drug Sumatriptan on Muscle Energy Metabolism: Relationship to Side-Effects

Cephalalgia ◽  
2000 ◽  
Vol 20 (1) ◽  
pp. 39-44 ◽  
Author(s):  
MD Boska ◽  
KMA Welch ◽  
L Schultz ◽  
J Nelson
Keyword(s):  
Skeletal Muscle ◽  
Energy Metabolism ◽  
Side Effects ◽  
Kinetic Data ◽  
Oxygen Storage ◽  
Resonance Spectroscopy ◽  
Sumatriptan Succinate ◽  
Muscle Energy ◽  
Creatine Kinase Reaction ◽  
Muscle Energy Metabolism

Sumatriptan succinate (Imitrex) is a 5-HT(5-hydroxytryptamine) agonist used for relief of migraine symptoms. Some individuals experience short-lived side-effects, including heaviness of the limbs, chest heaviness and muscle aches and pains. The effects of this drug on skeletal muscle energy metabolism were studied during short submaximal isometric exercises. We studied ATP flux from anaerobic glycolysis (An Gly), the creatine kinase reaction (CK) and oxidative phosphorylation (Ox Phos) using 31P nuclear magnetic resonance spectroscopy (31P MRS) kinetic data collected during exercise. It was found that side-effects induced acutely by injection of 6 mg sumatriptan succinate s.c. were associated with reduced oxygen storage in peripheral skeletal muscle 5–20 min after injection as demonstrated by a transient reduction in mitochondrial function at end-exercise. These results suggest that mild vasoconstriction in peripheral skeletal muscle is associated with the action of sumatriptan and is likely to be the source of the side-effects experienced by some users. Migraine with aura patients were more susceptible to this effect than migraine without aura patients.

scholarly journals Multinuclear MRS at 7T Uncovers Exercise Driven Differences in Skeletal Muscle Energy Metabolism Between Young and Seniors

2020 ◽  
Vol 11 ◽  
Author(s):  
Patrik Krumpolec ◽  
Radka Klepochová ◽  
Ivica Just ◽  
Marjeta Tušek Jelenc ◽  
Ivan Frollo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Energy Metabolism ◽  
Muscle Energy ◽  
Muscle Energy Metabolism

scholarly journals Regulation of skeletal muscle ATP catabolism by AMPD1 genotype during sprint exercise in asymptomatic subjects

2001 ◽  
Vol 91 (1) ◽  
pp. 258-264 ◽  
Author(s):  
Barbara Norman ◽  
Richard L. Sabina ◽  
Eva Jansson
Keyword(s):  
Skeletal Muscle ◽  
Energy Metabolism ◽  
Time Course ◽  
Fold Increase ◽  
Amp Deaminase ◽  
Biopsy Material ◽  
Plasma Ammonia ◽  
Muscle Energy ◽  
Muscle Energy Metabolism ◽  
Asymptomatic Subjects

Deficiency of myoadenylate deaminase, the muscle isoform of AMP deaminase encoded by the AMPD1 gene, is a common myopathic condition associated with alterations in skeletal muscle energy metabolism. However, recent studies have demonstrated that most individuals harboring this genetic abnormality are asymptomatic. Therefore, 18 healthy subjects with different AMPD1 genotypes were studied during a 30-s Wingate test in order to evaluate the influence of this inherited defect in AMPD1 expression on skeletal muscle energy metabolism and exercise performance in the asymptomatic population. Exercise performances were similar across the AMPD1 genotypes, whereas significant differences in several descriptors of energy metabolism were observed. Normal homozygotes (NN) exhibited the highest levels of AMP deaminase activities, net ATP catabolism, and IMP accumulation, whereas intermediate values were observed in heterozygotes (MN). Conversely, mutant homozygotes (MM) had very low AMP deaminase activities and showed no significant net catabolism of ATP or IMP accumulation. Accordingly, MM also did not show any postexercise increase in plasma ammonia. Unexpectedly, MN consistently exhibited greater increases in plasma ammonia compared with NN despite the relatively lower accumulation of IMP in skeletal muscle. Moreover, time course profiles of postexercise plasma ammonia and blood lactate accumulation also differed across AMPD1 genotypes. Finally, analysis of adenosine in leftover biopsy material revealed a modest twofold increase in MN and a dramatic 25-fold increase in MM.

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