scholarly journals Relationship Between Markers of Insulin Resistance, Markers of Adiposity, HbA1c, and Cognitive Functions in a Middle-Aged Population-Based Sample: the MONA LISA Study

Diabetes Care ◽  
2012 ◽  
Vol 36 (6) ◽  
pp. 1512-1521 ◽  
Author(s):  
C. M. Sanz ◽  
J.-B. Ruidavets ◽  
V. Bongard ◽  
J.-C. Marquie ◽  
H. Hanaire ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cognitive Functions ◽  
Population Based ◽  
Middle Aged ◽  
Aged Population ◽  
Resistance Markers ◽  
Mona Lisa

scholarly journals Association between nonsteroidal anti-inflammatory drugs and atrial fibrillation among a middle-aged population: a nationwide population-based cohort

2018 ◽  
Vol 84 (6) ◽  
pp. 1290-1300 ◽  
Author(s):  
Shao-Yuan Chuang ◽  
Pai-Feng Hsu ◽  
Fang-Ju Lin ◽  
Ya-Wen Huang ◽  
Gou-Zhau Wang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Population Based ◽  
Middle Aged ◽  
Aged Population ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Diabetes mellitus and its risk factors among a middle-aged population of Iran, a population-based study

2015 ◽  
Vol 36 (2) ◽  
pp. 189-196 ◽  
Author(s):  
Hossein Ebrahimi ◽  
Mohammad Hassan Emamian ◽  
Mohammad Shariati ◽  
Hassan Hashemi ◽  
Akbar Fotouhi
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Population Based ◽  
Middle Aged ◽  
Population Based Study ◽  
Aged Population

scholarly journals Concurrent assessment of urban environment and cardiometabolic risk over 10 years in a middle-aged population-based cohort

2018 ◽  
Vol 57 (1) ◽  
pp. 98-110 ◽  
Author(s):  
Mark Daniel ◽  
Suzanne J. Carroll ◽  
Theophile Niyonsenga ◽  
Ellie J. Piggott ◽  
Anne Taylor ◽  
...  
Keyword(s):  
Urban Environment ◽  
Cardiometabolic Risk ◽  
Population Based ◽  
Middle Aged ◽  
Aged Population ◽  
Concurrent Assessment

Metabolic syndrome and its risk factors among middle aged population of Iran, a population based study

2016 ◽  
Vol 10 (1) ◽  
pp. 19-22 ◽  
Author(s):  
Hossein Ebrahimi ◽  
Mohammad Hassan Emamian ◽  
Mohammad Shariati ◽  
Hassan Hashemi ◽  
Akbar Fotouhi
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Population Based ◽  
Middle Aged ◽  
Population Based Study ◽  
Aged Population

scholarly journals Hair Loss, Insulin Resistance, and Heredity in Middle-aged Women. a Population-based Study

2003 ◽  
Vol 10 (3) ◽  
pp. 227-231 ◽  
Author(s):  
V. Matilainen ◽  
M. Laakso ◽  
P. Hirsso ◽  
P. Koskela ◽  
U. Rajala ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Hair Loss ◽  
Population Based ◽  
Middle Aged ◽  
Population Based Study

scholarly journals Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men

2009 ◽  
Vol 161 (6) ◽  
pp. 947-954 ◽  
Author(s):  
David M Lee ◽  
Martin K Rutter ◽  
Terence W O'Neill ◽  
Steven Boonen ◽  
Dirk Vanderschueren ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Parathyroid Hormone ◽  
Population Based ◽  
Community Dwelling ◽  
Model Assessment ◽  
Middle Aged ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
The Relationship

ObjectivesLow serum 25-hydroxyvitamin D (25(OH)D) and elevated parathyroid hormone (PTH) levels have been linked to insulin resistance, the metabolic syndrome (MetS) and its components. Data in healthy, community-dwelling Europeans are lacking, and previous studies have not excluded subjects receiving drug treatments that may distort the relationship between 25(OH)D/PTH and MetS. The aim of our analysis was to examine the association of 25(OH)D and PTH with Adult Treatment Panel III-defined MetS in middle-aged and older European men.DesignThis was a population-based, cross-sectional study of 3369 men aged 40–79 years enrolled in the European Male Ageing Study.ResultsAfter exclusion of subjects with missing data, 3069 men with a mean (±s.d.) age of 60±11 years were included in the analysis. Age-adjusted 25(OH)D levels were inversely associated with waist circumference, systolic blood pressure (BP), triglycerides, and glucose (all P<0.01). Age-adjusted PTH levels were only associated with waist and diastolic BP (both P<0.05). After adjusting for age, centre, season and lifestyle factors the odds for MetS decreased across increasing 25(OH)D quintiles (odds ratios 0.48 (95% confidence intervals 0.36–0.64) highest versus lowest quintile; Ptrend<0.001). This relationship was unchanged after adjustment for PTH, but was attenuated after additional adjustment for homoeostasis model assessment of insulin resistance (0.60 (0.47–0.78); Ptrend<0.001). There was no association between PTH and MetS.ConclusionsOur results demonstrate an inverse relationship between 25(OH)D levels and MetS, which is independent of several confounders and PTH. The relationship is partly explained by insulin resistance. The clinical significance of these observations warrants further study.

scholarly journals Fatty liver predicts the risk for cardiovascular events in middle-aged population: a population-based cohort study

BMJ Open ◽  
2014 ◽  
Vol 4 (3) ◽  
pp. e004973 ◽  
Author(s):  
Pauliina Pisto ◽  
Merja Santaniemi ◽  
Risto Bloigu ◽  
Olavi Ukkola ◽  
Y Antero Kesäniemi
Keyword(s):  
Cohort Study ◽  
Fatty Liver ◽  
Cardiovascular Events ◽  
Population Based ◽  
Middle Aged ◽  
Aged Population

scholarly journals Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation : longitudinal analyses in middle-aged men

2008 ◽  
Vol 99 (6) ◽  
pp. 1186-1189 ◽  
Author(s):  
Helena Petersson ◽  
Samar Basu ◽  
Tommy Cederholm ◽  
Ulf Risérus
Keyword(s):  
Insulin Resistance ◽  
Fatty Acid ◽  
Large Population ◽  
Population Based ◽  
Middle Aged ◽  
Swedish Population ◽  
Serum Fatty Acid ◽  
Fa Composition ◽  
Stearoyl Coa Desaturase ◽  
Δ6 Desaturase

Altered fatty acid (FA) composition is related to insulin resistance and CVD. One possible mediator may be inflammation, but longitudinal data relating FA composition to inflammation taking insulin resistance into account are limited. We investigated the long-term association between FA composition and C-reactive protein (CRP) concentrations in a large population-based cohort study in 767 men followed for 20 years. The association between FA composition in serum cholesteryl esters at age 50 and CRP concentrations at age 70 was investigated using linear regression. In addition, desaturase activities (stearoyl-CoA desaturase-1 (SCD-1), Δ5- and Δ6-desaturase) were estimated using FA product-to-precursor ratios. Insulin resistance was measured directly at follow-up by euglycaemic clamp. After adjusting for confounders (smoking, physical activity, alcohol intake, obesity and erythrocyte sedimentation rate) CRP concentrations were inversely associated with the proportion of 18 : 2n-6 (P = 0·002) and positively associated with 16 : 1n-7 (P = 0·008), 18 : 1n-9 (P = 0·0003), 20 : 5n-3 (P = 0·04) and estimated SCD-1 (P = 0·005) and Δ6-desaturase (P = 0·02) activities. After adding insulin resistance to the model, 18 : 1n-9, 18 : 2n-6 and SCD-1 remained significant predictors of CRP. A FA composition indicating low intake of 18 : 2n-6, high intake of SFA and high SCD-1 activity is, in a Swedish population of middle-aged men, associated with CRP concentrations 20 years later, even independently of obesity and insulin resistance.

scholarly journals The minimum-mortality estimated glomerular filtration rate percentile shifts upward in the aged population: a nationwide population-based study

2020 ◽  
Author(s):  
Yaerim Kim ◽  
Soojin Lee ◽  
Yeonhee Lee ◽  
Sehoon Park ◽  
Sanghyun Park ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
The Elderly ◽  
Population Based ◽  
Middle Aged ◽  
Aged Group ◽  
Aged Population ◽  
All Cause Mortality

Abstract Background The estimated glomerular filtration rate (eGFR) is a biomarker not only for kidney function, but also for major clinical outcomes. We aimed to evaluate the patterns of mortality across the entire eGFR percentile spectrum using a population-based dataset. Methods We retrospectively reviewed the National Health Insurance Service (NHIS) database for people who received nationwide health check-ups from 2009 to 2012. Subjects who were ≥45 years old and had one or more serum creatinine values available were included in the study. The primary outcome was all-cause mortality as a function of eGFR percentile. Results The middle-aged group (45–64 years) showed a U-shaped pattern of association between eGFR percentile and all-cause mortality. The minimum-mortality eGFR percentile was shifted upward in the elderly group (≥65 years). Specifically, the minimum-mortality eGFR percentiles were the 28th percentile (83.8 mL/min/1.73 m2) for middle-aged males, the 63rd percentile (86.2 mL/min/1.73 m2) for elderly males, the 42nd percentile (102.8 mL/min/1.73 m2) for middle-aged females and the 75th percentile (90.1 mL/min/1.73 m2) for elderly females. Diabetes and hypertension shifted the minimum-mortality eGFR percentile upward in the middle-aged group. This pattern was attenuated in the elderly group. Conclusions The eGFR percentile showing minimum mortality moves upward in the aged population as well as patients with diabetes and hypertension, which might reduce the clinical significance of hyperfiltration. Risk stratification for mortality should be approached differently according to the specific conditions of the patient group.

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