scholarly journals Does Elevated Plasma Triglyceride Level Independently Predict Impaired Fasting Glucose?: The Multi-Ethnic Study of Atherosclerosis (MESA)

Diabetes Care ◽  
2012 ◽  
Vol 36 (2) ◽  
pp. 342-347 ◽  
Author(s):  
S. X. Lin ◽  
I. Berlin ◽  
R. Younge ◽  
Z. Jin ◽  
C. T. Sibley ◽  
...  
2014 ◽  
Vol 11 (4) ◽  
pp. 831-837 ◽  
Author(s):  
Paul A. McAuley ◽  
Haiying Chen ◽  
Duck-chul Lee ◽  
Enrique Garcia Artero ◽  
David A. Bluemke ◽  
...  

Background:The influence of higher physical activity on the relationship between adiposity and cardiometabolic risk is not completely understood.Methods:Between 2000–2002, data were collected on 6795 Multi-Ethnic Study of Atherosclerosis (MESA) participants. Self-reported intentional physical activity in the lowest quartile (0–105 MET-minutes/week) was categorized as inactive and the upper three quartiles (123–37,260 MET-minutes/week) as active. Associations of body mass index (BMI) and waist circumference categories, stratified by physical activity status (inactive or active) with cardiometabolic risk factors (dyslipidemia, hypertension, upper quartile of homeostasis model assessment of insulin resistance [HOMA-IR] for population, and impaired fasting glucose or diabetes) were assessed using logistic regression analysis adjusting for age, gender, race/ethnicity, and current smoking.Results:Among obese participants, those who were physically active had reduced odds of insulin resistance (47% lower; P < .001) and impaired fasting glucose/diabetes (23% lower; P = .04). These associations were weaker for central obesity. However, among participants with a normal waist circumference, those who were inactive were 63% more likely to have insulin resistance (OR [95% CI] 1.63 [1.24–2.15]) compared with the active reference group.Conclusions:Physical activity was inversely related to the cardiometabolic risk associated with obesity and central obesity.


2016 ◽  
Vol 64 (2) ◽  
pp. 383-387 ◽  
Author(s):  
Amani Beshara ◽  
Eytan Cohen ◽  
Elad Goldberg ◽  
Pearl Lilos ◽  
Moshe Garty ◽  
...  

The relationship between triglyceridemia and diabetes mellitus remains unclear. This study evaluated the risk of diabetes and impaired fasting glucose associated with a wide range of triglyceride levels. A longitudinal retrospective study was carried out employing data from a screening center between the years 2000 and 2012. Inclusion criteria were absence of diabetes at baseline and attendance at the center at least twice over a 5-year period. Participants were divided by fasting blood glucose level (normal/impaired) at the first visit. A total of 5085 participants were eligible for the study. Of the 4164 normoglycemic participants at baseline, 40 (0.96%) had diabetes and 998 (24%) had impaired fasting glucose by the end of the study. On stepwise logistic regression analysis, every 10 mg/dL increase in triglyceride level significantly increased the risk of diabetes by 4% and of impaired fasting glucose by 2% (p<0.001). This association held true even when rising triglyceride levels remained within the accepted normal range (<150 mg/dL, p<0.001). Sustained increments in serum triglyceride level, even within the accepted normal range, are an independent risk factor for diabetes mellitus and impaired fasting glucose in normoglycemic participants.


2001 ◽  
Vol 65 (5) ◽  
pp. 1071-1075 ◽  
Author(s):  
Toshiaki AOYAMA ◽  
Mitsutaka KOHNO ◽  
Tsutomu SAITO ◽  
Kensuke FUKUI ◽  
Kiyoharu TAKAMATSU ◽  
...  

2013 ◽  
Vol 12 (1) ◽  
pp. 97 ◽  
Author(s):  
Ying Gao ◽  
Xiang Xie ◽  
Yi-Tong Ma ◽  
Yi-Ning Yang ◽  
Xiao-Mei Li ◽  
...  

iScience ◽  
2020 ◽  
Vol 23 (4) ◽  
pp. 100973
Author(s):  
Yu-Xin Xu ◽  
Gina M. Peloso ◽  
Taylor H. Nagai ◽  
Taiji Mizoguchi ◽  
Amy Deik ◽  
...  

1988 ◽  
Vol 11 (3) ◽  
pp. 209-211 ◽  
Author(s):  
M. Valbonesi ◽  
D. Occhini ◽  
C. Capra ◽  
R. Frisoni ◽  
M. Fella ◽  
...  

The Authors report a case of hypertriglyceridemia complicating the course of a patient receiving cyclosporin A after bone marrow transplantation. When the patient was seen at the hemapheresis unit the clinical picture was characterized by headache, increasing visual and neurological disturbances. Plasma triglyceride level was 3215 mg/dl. Two plasma exchange sessions reduced triglycerides to 486 mg/dl and halted the disease progression. This may represent the first plasma exchange treatment of cyclosporin A-induced hypertriglyceridemia.


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