scholarly journals The Application of the Diabetes Prevention Trial-Type 1 Risk Score for Identifying a Preclinical State of Type 1 Diabetes

Diabetes Care ◽  
2012 ◽  
Vol 35 (7) ◽  
pp. 1552-1555 ◽  
Author(s):  
J. M. Sosenko ◽  
J. S. Skyler ◽  
J. Mahon ◽  
J. P. Krischer ◽  
C. A. Beam ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Risk Score ◽  
Trial Type ◽  
Diabetes Prevention ◽  
Prevention Trial

scholarly journals A Risk Score for Type 1 Diabetes Derived From Autoantibody-Positive Participants in the Diabetes Prevention Trial-Type 1

Diabetes Care ◽  
2007 ◽  
Vol 31 (3) ◽  
pp. 528-533 ◽  
Author(s):  
J. M. Sosenko ◽  
J. P. Krischer ◽  
J. P. Palmer ◽  
J. Mahon ◽  
C. Cowie ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Risk Score ◽  
Trial Type ◽  
Diabetes Prevention ◽  
Prevention Trial

scholarly journals Use of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS) for Improving the Accuracy of the Risk Classification of Type 1 Diabetes

Diabetes Care ◽  
2014 ◽  
Vol 37 (4) ◽  
pp. 979-984 ◽  
Author(s):  
Jay M. Sosenko ◽  
Jay S. Skyler ◽  
Jeffrey Mahon ◽  
Jeffrey P. Krischer ◽  
Carla J. Greenbaum ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Risk Score ◽  
Trial Type ◽  
Diabetes Prevention ◽  
Risk Classification ◽  
Prevention Trial

scholarly journals One-Hour Oral Glucose Tolerance Tests for the Prediction and Diagnostic Surveillance of Type 1 Diabetes

2020 ◽  
Vol 105 (11) ◽  
Author(s):  
Kimber M Simmons ◽  
Jay M Sosenko ◽  
Megan Warnock ◽  
Susan Geyer ◽  
Heba M Ismail ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glucose Tolerance ◽  
Risk Score ◽  
Trial Type ◽  
Diabetes Prevention ◽  
Prevention Trial ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
C Peptide

Abstract Context Once islet autoantibody–positive individuals are identified, predicting which individuals are at highest risk for type 1 diabetes (T1D) is important. A metabolic risk score derived from 2-hour oral glucose tolerance test (OGTT) data, the Diabetes Prevention Trial-Type 1 risk score (DPTRS), can accurately predict T1D. However, 2-hour OGTTs are time-consuming and costly. Objective We aimed to determine whether a risk score derived from 1-hour OGTT data can predict T1D as accurately as the DPTRS. Secondarily, we evaluated whether a 1-hour glucose value can be used for diagnostic surveillance. Methods The DPTRS was modified to derive a 1-hour OGTT risk score (DPTRS60) using fasting C-peptide, 1-hour glucose and C-peptide, age, and body mass index. Areas under receiver operating curves (ROCAUCs) were used to compare prediction accuracies of DPTRS60 with DPTRS in Diabetes Prevention Trial–Type 1 (DPT-1) (n = 654) and TrialNet Pathway to Prevention (TNPTP) (n = 4610) participants. Negative predictive values (NPV) for T1D diagnosis were derived for 1-hour glucose thresholds. Results ROCAUCs for T1D prediction 5 years from baseline were similar between DPTRS60 and DPTRS (DPT-1: 0.805 and 0.794; TNPTP: 0.832 and 0.847, respectively). DPTRS60 predicted T1D significantly better than 2-hour glucose (P < .001 in both cohorts). A 1-hour glucose of less than 180 mg/dL had a similar NPV, positive predictive value, and specificity for T1D development before the next 6-month visit as the standard 2-hour threshold of less than 140 mg/dL (both ≥ 98.5%). Conclusion A 1-hour OGTT can predict T1D as accurately as a 2-hour OGTT with minimal risk of missing a T1D diagnosis before the next visit.

scholarly journals Patterns of Metabolic Progression to Type 1 Diabetes in the Diabetes Prevention Trial-Type 1

Diabetes Care ◽  
2006 ◽  
Vol 29 (3) ◽  
pp. 643-649 ◽  
Author(s):  
J. M. Sosenko ◽  
J. P. Palmer ◽  
C. J. Greenbaum ◽  
J. Mahon ◽  
C. Cowie ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Trial Type ◽  
Diabetes Prevention ◽  
Prevention Trial

scholarly journals Glucose and C-Peptide Changes in the Perionset Period of Type 1 Diabetes in the Diabetes Prevention Trial-Type 1

Diabetes Care ◽  
2008 ◽  
Vol 31 (11) ◽  
pp. 2188-2192 ◽  
Author(s):  
J. M. Sosenko ◽  
J. P. Palmer ◽  
L. Rafkin-Mervis ◽  
J. P. Krischer ◽  
D. Cuthbertson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Trial Type ◽  
Diabetes Prevention ◽  
Prevention Trial ◽  
C Peptide

scholarly journals Pancreatic Islet Autoantibodies as Predictors of Type 1 Diabetes in the Diabetes Prevention Trial-Type 1

Diabetes Care ◽  
2009 ◽  
Vol 32 (12) ◽  
pp. 2269-2274 ◽  
Author(s):  
T. Orban ◽  
J. M. Sosenko ◽  
D. Cuthbertson ◽  
J. P. Krischer ◽  
J. S. Skyler ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Pancreatic Islet ◽  
Trial Type ◽  
Diabetes Prevention ◽  
Prevention Trial ◽  
Islet Autoantibodies

scholarly journals Incident Dysglycemia and Progression to Type 1 Diabetes Among Participants in the Diabetes Prevention Trial-Type 1

Diabetes Care ◽  
2009 ◽  
Vol 32 (9) ◽  
pp. 1603-1607 ◽  
Author(s):  
J. M. Sosenko ◽  
J. P. Palmer ◽  
L. Rafkin-Mervis ◽  
J. P. Krischer ◽  
D. Cuthbertson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Trial Type ◽  
Diabetes Prevention ◽  
Prevention Trial
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