scholarly journals Lipids in the Wrong Place: Visceral Fat and Nonalcoholic Steatohepatitis

Diabetes Care ◽  
2011 ◽  
Vol 34 (Supplement_2) ◽  
pp. S367-S370 ◽  
Author(s):  
G. Perseghin
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
Visceral Fat ◽  
Wrong Place

Liver Histological Improvement After Administration of High-Dose Vitamin C in Guinea Pig with Nonalcoholic Steatohepatitis

2018 ◽  
Vol 88 (5-6) ◽  
pp. 263-269
Author(s):  
Seong-Hoon Park ◽  
A Lum Han ◽  
Na-Hyung Kim ◽  
Sae-Ron Shin
Keyword(s):  
Liver Biopsy ◽  
Vitamin C ◽  
Nonalcoholic Steatohepatitis ◽  
Guinea Pigs ◽  
Normal Diet ◽  
High Dose ◽  
Biochemical Tests ◽  
Deficient Diet ◽  
Histological Improvement ◽  
Vit C

Abstract. Background: Vitamin C is a strong antioxidant, and the health effects of vitamin C megadoses have not been validated despite the apparent health benefits. Therefore, the present study sought to confirm the effects of vitamin C megadoses. Materials and Methods : Four groups of six guinea pigs were used. Each group was fed one of the following diets for three weeks: normal diet, methionine choline-deficient diet, methionine choline-deficient diet + vitamin C megadose (MCD + vit C 2.5 g/kg/day), and methionine-choline deficient diet + ursodeoxycholic acid (MCD + UDCA 30 mg/kg/day). The MCD diet was given to induce nonalcoholic steatohepatitis, and UDCA was used to treat nonalcoholic steatohepatitis. Three weeks after initial diet administration, the results of biochemical tests and liver biopsy were compared between the groups. Results: The cytoplasm state was similar in the MCD + vit C and MCD + UDCA groups, exhibiting clearing of the cytoplasm and ballooning degeneration. However, macrovesicular steatosis was not observed in the MCD + vit C group. Aspartate transaminase and alanine transaminase were elevated significantly following vitamin C administration. Conclusions: The present study confirmed that alone vitamin C megadoses are potential remedies for nonalcoholic steatohepatitis, based on the liver biopsy results of guinea pigs that were unable to synthesize vitamin C.

Visceral fat drives 5[alpha]-reductase activity independent of BMI in women with polycystic ovarian syndrome

2015 ◽  
Author(s):  
Punith Kempegowda ◽  
Michael W O'Reilly ◽  
Nicola J Crabtree ◽  
Angela E Taylor ◽  
Beverly A Hughes ◽  
...  
Keyword(s):  
Visceral Fat ◽  
Polycystic Ovarian Syndrome ◽  
Reductase Activity ◽  
Ovarian Syndrome

Exenatide Treatment Improves Mitochondrial Metabolism and Hepatic Insulin Sensitivity in Mice with Nonalcoholic Steatohepatitis (NASH)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1846-P
Author(s):  
SRILAXMI KALAVALAPALLI ◽  
FERNANDO BRIL ◽  
ARIANA VERGARA ◽  
NISHANTH SUNNY ◽  
KENNETH CUSI
Keyword(s):  
Insulin Sensitivity ◽  
Nonalcoholic Steatohepatitis ◽  
Mitochondrial Metabolism ◽  
Hepatic Insulin Sensitivity
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