scholarly journals Prognostic Value of Resting Heart Rate on Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients: A competing risk analysis in a prospective cohort

Diabetes Care ◽  
2012 ◽  
Vol 35 (10) ◽  
pp. 2069-2075 ◽  
Author(s):  
A. Miot ◽  
S. Ragot ◽  
W. Hammi ◽  
P.-J. Saulnier ◽  
P. Sosner ◽  
...  
2007 ◽  
Vol 24 (1) ◽  
pp. 18-26 ◽  
Author(s):  
V. Urbančič-Rovan ◽  
B. Meglič ◽  
A. Stefanovska ◽  
A. Bernjak ◽  
K. Ažman-Juvan ◽  
...  

2014 ◽  
Vol 30 (4) ◽  
pp. 305-312 ◽  
Author(s):  
Ildikó Istenes ◽  
Anna Erzsébet Körei ◽  
Zsuzsanna Putz ◽  
Nóra Németh ◽  
Timea Martos ◽  
...  

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Vendula Bartáková ◽  
Linda Klimešová ◽  
Katarína Kianičková ◽  
Veronika Dvořáková ◽  
Denisa Malúšková ◽  
...  

Elevated resting heart rate (RHR) has been associated with increased risk of mortality and cardiovascular events. Limited data are available so far in type 2 diabetic (T2DM) subjects with no study focusing on progressive renal decline specifically. Aims of our study were to verify RHR as a simple and reliable predictor of adverse disease outcomes in T2DM patients. A total of 421 T2DM patients with variable baseline stage of diabetic kidney disease (DKD) were prospectively followed. A history of the cardiovascular disease was present in 81 (19.2%) patients at baseline, and DKD (glomerular filtration rate < 60 mL/min or proteinuria) was present in 328 (77.9%) at baseline. Progressive renal decline was defined as a continuous rate of glomerular filtration rate loss ≥ 3.3% per year. Resting heart rate was not significantly higher in subjects with cardiovascular disease or DKD at baseline compared to those without. Using time-to-event analyses, significant differences in the cumulative incidence of the studied outcomes, that is, progression of DKD (and specifically progressive renal decline), major advanced cardiovascular event, and all-cause mortality, between RHR </≥65 (arbitrary cut-off) and 75 (median) bpm were not found. We did not ascertain predictive value of the RHR for the renal or cardiovascular outcomes in T2DM subjects in Czech Republic.


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