scholarly journals IgA Anti-transglutaminase Autoantibodies at Type 1 Diabetes Onset Are Less Frequent in Adult Patients and Are Associated With a General Celiac-Specific Lower Immune Response in Comparison With Nondiabetic Celiac Patients at Diagnosis

Diabetes Care ◽  
2012 ◽  
Vol 35 (10) ◽  
pp. 2083-2085 ◽  
Author(s):  
C. Tiberti ◽  
F. Panimolle ◽  
M. Bonamico ◽  
B. Shashaj ◽  
T. Filardi ◽  
...  
Keyword(s):  
Immune Response ◽  
Type 1 Diabetes ◽  
Adult Patients ◽  
Diabetes Onset ◽  
Lower Immune Response

Vitamin D status and bone metabolism in adult patients with Type 1 diabetes mellitus

2019 ◽  
Author(s):  
Eleftheria Barmpa ◽  
Spyros Karamagiolis ◽  
Stelios Tigas ◽  
Georgios N Koukoulis ◽  
Alexandra Bargiota
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Bone Metabolism ◽  
Adult Patients ◽  
Vitamin D Status

A Novel Dual-Function GLP-1 Analogue Prevents Type 1 Diabetes Onset in NOD Mice by Controlling the Balance of Treg/Th17 and Th2/Th1

2019 ◽  
Author(s):  
Fujian Qin ◽  
Yanfeng Zhang ◽  
Kaiying Li ◽  
Huashan Gao ◽  
Qian Zhao ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Nod Mice ◽  
Dual Function ◽  
Diabetes Onset

scholarly journals Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomised controlled trial

Diabetologia ◽  
2021 ◽  
Author(s):  
Robin Assfalg ◽  
Jan Knoop ◽  
Kristi L. Hoffman ◽  
Markus Pfirrmann ◽  
Jose Maria Zapardiel-Gonzalo ◽  
...  
Keyword(s):  
Immune Response ◽  
Type 1 Diabetes ◽  
Randomised Controlled Trial ◽  
Primary Outcome ◽  
Controlled Trial ◽  
Antibody Responses ◽  
Oral Insulin ◽  
Cell Responses ◽  
Randomised Controlled

Abstract Aims/hypothesis Oral administration of antigen can induce immunological tolerance. Insulin is a key autoantigen in childhood type 1 diabetes. Here, oral insulin was given as antigen-specific immunotherapy before the onset of autoimmunity in children from age 6 months to assess its safety and immune response actions on immunity and the gut microbiome. Methods A phase I/II randomised controlled trial was performed in a single clinical study centre in Germany. Participants were 44 islet autoantibody-negative children aged 6 months to 2.99 years who had a first-degree relative with type 1 diabetes and a susceptible HLA DR4-DQ8-containing genotype. Children were randomised 1:1 to daily oral insulin (7.5 mg with dose escalation to 67.5 mg) or placebo for 12 months using a web-based computer system. The primary outcome was immune efficacy pre-specified as induction of antibody or T cell responses to insulin and measured in a central treatment-blinded laboratory. Results Randomisation was performed in 44 children. One child in the placebo group was withdrawn after the first study visit and data from 22 insulin-treated and 21 placebo-treated children were analysed. Oral insulin was well tolerated with no changes in metabolic variables. Immune responses to insulin were observed in children who received both insulin (54.5%) and placebo (66.7%), and the trial did not demonstrate an effect on its primary outcome (p = 0.54). In exploratory analyses, there was preliminary evidence that the immune response and gut microbiome were modified by the INS genotype Among children with the type 1 diabetes-susceptible INS genotype (n = 22), antibody responses to insulin were more frequent in insulin-treated (72.7%) as compared with placebo-treated children (18.2%; p = 0.03). T cell responses to insulin were modified by treatment-independent inflammatory episodes. Conclusions/interpretation The study demonstrated that oral insulin immunotherapy in young genetically at-risk children was safe, but was not associated with an immune response as predefined in the trial primary outcome. Exploratory analyses suggested that antibody responses to oral insulin may occur in children with a susceptible INS genotype, and that inflammatory episodes may promote the activation of insulin-responsive T cells. Trial registration Clinicaltrials.gov NCT02547519 Funding The main funding source was the German Center for Diabetes Research (DZD e.V.) Graphical abstract

Thyroid autoantibodies and their clinical relevance in young adults with Type 1 diabetes during the first 12 yr after diabetes onset

2004 ◽  
Vol 27 (8) ◽  
pp. 728-732 ◽  
Author(s):  
K. Vondra ◽  
J. Vrbíková ◽  
I. Šterzl ◽  
R. Bílek ◽  
M. Vondrova ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Clinical Relevance ◽  
Thyroid Autoantibodies ◽  
Diabetes Onset

Type 1 Diabetes onset and COVID-19 infection in a child with Sanjad Sakati Syndrome: a case from Kuwait

2021 ◽  
Author(s):  
Fouzeyah OTHMAN ◽  
Dr. Fawzia Mandani ◽  
Dr. Zaidan Al-Mazidi ◽  
Dr. Khalid Al-Kandari
Keyword(s):  
Type 1 Diabetes ◽  
Diabetes Onset

Impaired Primary Immune Response in Type-1 Diabetes: Results from a Controlled Vaccination Study

2002 ◽  
Vol 103 (3) ◽  
pp. 249-259 ◽  
Author(s):  
Nicole Eibl ◽  
Martin Spatz ◽  
Gottfried F. Fischer ◽  
Wolfgang R. Mayr ◽  
Aysen Samstag ◽  
...  
Keyword(s):  
Immune Response ◽  
Type 1 Diabetes ◽  
Primary Immune Response
Sign in / Sign up

Export Citation Format

Share Document