scholarly journals Meat Consumption and Its Association With C-Reactive Protein and Incident Type 2 Diabetes: The Rotterdam Study

Diabetes Care ◽  
2012 ◽  
Vol 35 (7) ◽  
pp. 1499-1505 ◽  
Author(s):  
G. J. van Woudenbergh ◽  
A. Kuijsten ◽  
B. Tigcheler ◽  
E. J. G. Sijbrands ◽  
F. J. A. van Rooij ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Meat Consumption ◽  
Rotterdam Study ◽  
C Reactive Protein ◽  
Incident Type ◽  
Reactive Protein ◽  
Incident Type 2 Diabetes

scholarly journals High-Sensitivity C-Reactive Protein Is Associated With Incident Type 2 Diabetes Among African Americans: The Jackson Heart Study

Diabetes Care ◽  
2015 ◽  
Vol 38 (9) ◽  
pp. 1694-1700 ◽  
Author(s):  
Valery S. Effoe ◽  
Adolfo Correa ◽  
Haiying Chen ◽  
Mary E. Lacy ◽  
Alain G. Bertoni
Keyword(s):  
Type 2 Diabetes ◽  
African Americans ◽  
High Sensitivity ◽  
Jackson Heart Study ◽  
C Reactive Protein ◽  
Incident Type ◽  
Reactive Protein ◽  
Heart Study ◽  
Incident Type 2 Diabetes

scholarly journals Novel metabolic indices and incident type 2 diabetes among women and men: the Rotterdam Study

Diabetologia ◽  
2019 ◽  
Vol 62 (9) ◽  
pp. 1581-1590 ◽  
Author(s):  
Adela Brahimaj ◽  
Fernando Rivadeneira ◽  
Taulant Muka ◽  
Eric J. G. Sijbrands ◽  
Oscar H. Franco ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Rotterdam Study ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Metabolic Indices

scholarly journals Prospective Associations of Systemic and Urinary Choline Metabolites with Incident Type 2 Diabetes

2016 ◽  
Vol 62 (5) ◽  
pp. 755-765 ◽  
Author(s):  
Gard F T Svingen ◽  
Hall Schartum-Hansen ◽  
Eva R Pedersen ◽  
Per M Ueland ◽  
Grethe S Tell ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Hdl Cholesterol ◽  
Prospective Data ◽  
Incident Type ◽  
Reactive Protein ◽  
Urine Albumin ◽  
Net Reclassification Improvement ◽  
Incident Type 2 Diabetes

Abstract BACKGROUND Several compounds in the choline oxidation pathway are associated with insulin resistance and prevalent diabetes; however, prospective data are scarce. We explored the relationships between systemic and urinary choline-related metabolites and incident type 2 diabetes in an observational prospective study among Norwegian patients. METHODS We explored risk associations by logistic regression among 3621 nondiabetic individuals with suspected stable angina pectoris, of whom 3242 provided urine samples. Reclassification of patients was investigated according to continuous net reclassification improvement (NRI >0). RESULTS After median (25th to 75th percentile) follow-up of 7.5 (6.4–8.7) years, 233 patients (6.4%) were registered with incident type 2 diabetes. In models adjusted for age, sex, and fasting status, plasma betaine was inversely related to new-onset disease [odds ratio (OR) per 1 SD, 0.72; 95% CI, 0.62–0.83; P < 0.00001], whereas positive associations were observed for urine betaine (1.25; 1.09–1.43; P = 0.001), dimethylglycine (1.22; 1.06–1.40; P = 0.007), and sarcosine (1.30; 1.13–1.49; P < 0.001). The associations were maintained in a multivariable model adjusting for body mass index, hemoglobin A1c, urine albumin-to-creatinine ratio, estimated glomerular filtration rate, C-reactive protein, HDL cholesterol, and medications. Plasma betaine and urine sarcosine, the indices most strongly related to incident type 2 diabetes, improved reclassification [NRI >0 (95% CI) 0.33 (0.19–0.47) and 0.16 (0.01–0.31), respectively] and showed good within-person reproducibility. CONCLUSIONS Systemic and urinary concentrations of several choline metabolites were associated with risk of incident type 2 diabetes, and relevant biomarkers may improve risk prediction.

scholarly journals Processed and Unprocessed Red Meat Consumption and Incident Type 2 Diabetes Among French Women

Diabetes Care ◽  
2011 ◽  
Vol 35 (1) ◽  
pp. 128-130 ◽  
Author(s):  
M. Lajous ◽  
L. Tondeur ◽  
G. Fagherazzi ◽  
B. de Lauzon-Guillain ◽  
M.-C. Boutron-Ruaualt ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Meat Consumption ◽  
Red Meat ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals Glycemic Index and Glycemic Load and Their Association with C-Reactive Protein and Incident Type 2 Diabetes

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Geertruida J. van Woudenbergh ◽  
Anneleen Kuijsten ◽  
Eric J. G. Sijbrands ◽  
Albert Hofman ◽  
Jacqueline C. M. Witteman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Index ◽  
Glycemic Load ◽  
Positive Association ◽  
Diabetes Incidence ◽  
Linear Regression Models ◽  
C Reactive Protein ◽  
Incident Type ◽  
Reactive Protein

Objective. To investigate whether the Glycemic Index (GI) or Glycemic Load (GL) of a diet is associated with C-reactive Protein (CRP) and risk of type 2 diabetes in a prospective study.Materials and Methods. Our analysis included 4,366 participants who did not have diabetes at baseline. During follow-up 456 diabetes cases were confirmed. Dietary GI and GL were derived from a food-frequency questionnaire and its association with CRP was examined cross-sectionally using linear regression models. The association of GI and GL with diabetes incidence was examined using Cox proportional hazard models.Results. GL, but not GI, was associated with lnCRP at baseline (bGL=0.11per 50 units;P=.01). When comparing the highest to the lowest tertile of GI with respect to diabetes incidence, a Relative Risk (RR) of 0.95 [95%CI 0.75, 1.21] was found after adjustment for lifestyle and nutritional factors. For GL the RR for diabetes incidence was 1.00 [95%CI 0.74, 1.36]. Additional adjustment for CRP did not change RRs.Conclusion. Since GI was not associated with CRP and risk of type 2 diabetes, it is unlikely that a high GI diet induces the previously shown positive association between CRP and risk of type 2 diabetes by increasing CRP concentrations.

scholarly journals C-Reactive Protein Partially Mediates the Inverse Association Between Coffee Consumption and Risk of Type 2 Diabetes: The UK Biobank and the Rotterdam Study Cohorts

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1070-1070
Author(s):  
Carolina Ochoa-Rosales ◽  
Niels van der Schaft ◽  
Kim Braun ◽  
Frederick Ho ◽  
Fanny Petermann ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Systemic Inflammation ◽  
Coffee Consumption ◽  
Uk Biobank ◽  
Rotterdam Study ◽  
C Reactive Protein ◽  
Coffee Intake ◽  
Reactive Protein ◽  
Filtered Coffee

Abstract Objectives Given its popularity, there is an increasing interest in the study of coffee intake and its effect on health. Previous studies linked coffee consumption to lower type 2 diabetes (T2D) risk. However, potential underlying mechanisms remain unclear. We hypothesized that coffee's effects on systemic inflammation may play a role. We studied cross sectional and longitudinal associations of habitual coffee consumption with T2D risk and inflammation. Methods Participants from UK Biobank (UKB, n = 145,370) and Rotterdam Study (RS, n = 7172) cohorts were included. Coffee intake data were collected through self-administrated food frequency questionnaire or during home interviews. We studied associations of coffee intake with incident T2D using cox proportional hazard models; with longitudinally measured insulin resistance (HOMA IR) through linear mixed effect models; with serum baseline levels of inflammation markers using linear regressions; and the role of inflammation in coffee-T2D associations using mediation analysis. Models were adjusted for sociodemographic, lifestyle and health factors. Results were respectively expressed as hazard ratio (HR); β log transformed HOMA IR level; β log transformed ug/mL; and percentage mediated; and 95% confidence interval [95% CI]. Results UKB participants were 58% female and 55.2 years in average; RS were 59.7% female and 65.1 years. The median follow up was 7 (UKB) and 9 (RS) years. The modal coffee consumption was 0.5–2 cups/day (UKB) and 3–4 cups/day (RS). An increase of one coffee cup/day was associated with 4–6% lower T2D risk (RS HR 0.94 [95% CI 0.90; 0.98]; UKB HR 0.96 [0.94; 0.98]); lower HOMA IR (RS β −0.017 [−0.024; −0.010]); lower C reactive protein (CRP, RS β −0.014 [−0.022; −0.005]; UKBB β −0.011 [−0.012; −0.009] and higher adiponectin (RS β 0.025 [0.007; 0.042]. About coffee types, habitual consumers of filtered coffee had the lowest T2D risk (UKB HR 0.88 [0.83; 0.93]), compared to decaffeinated or instantaneous coffee. CRP levels mediated 9.6% (UKB) and 3.4% (RS) of the total effect of coffee on T2D. Adiponectin also showed evidence for mediation. Conclusions Coffee's beneficial effects on lower T2D risk may be partially mediated by improvements in systemic inflammation. Among coffee drinkers, filtered coffee may be of preference. Funding Sources Partially funded by the Institute for Scientific Information on Coffee.

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