scholarly journals Reduction in the Incidence of Type 2 Diabetes With the Mediterranean Diet: Results of the PREDIMED-Reus nutrition intervention randomized trial

Diabetes Care ◽  
2010 ◽  
Vol 34 (1) ◽  
pp. 14-19 ◽  
Author(s):  
J. Salas-Salvado ◽  
M. Bullo ◽  
N. Babio ◽  
M. A. Martinez-Gonzalez ◽  
N. Ibarrola-Jurado ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Randomized Trial ◽  
Mediterranean Diet ◽  
Nutrition Intervention ◽  
The Mediterranean

scholarly journals Erratum. Reduction in the Incidence of Type 2 Diabetes With the Mediterranean Diet: Results of the PREDIMED-Reus nutrition intervention randomized trial. Diabetes Care 2011;34:14–19

Diabetes Care ◽  
2018 ◽  
Vol 41 (10) ◽  
pp. 2259-2260 ◽  
Author(s):  
Jordi Salas-Salvadó ◽  
Monica Bulló ◽  
Nancy Babio ◽  
Miguel Ángel Martínez-González ◽  
Núria Ibarrola-Jurado ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Randomized Trial ◽  
Mediterranean Diet ◽  
Diabetes Care ◽  
Nutrition Intervention ◽  
The Mediterranean

The Mediterranean Diet and Two-Year Changes in Cognitive Function in Puerto Rican Adults With vs. Without Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 192-LB
Author(s):  
JOSIEMER MATTEI ◽  
SHERMAN J. BIGORNIA ◽  
MERCEDES SOTOS-PRIETO ◽  
TAMMY SCOTT ◽  
XIANG GAO ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cognitive Function ◽  
Puerto Rican ◽  
Mediterranean Diet ◽  
The Mediterranean

The Mediterranean diet and risk of type 2 diabetes in Iranian population

2018 ◽  
Vol 73 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Sajjad Khalili-Moghadam ◽  
Parvin Mirmiran ◽  
Zahra Bahadoran ◽  
Fereidoun Azizi
Keyword(s):  
Type 2 Diabetes ◽  
Mediterranean Diet ◽  
Iranian Population ◽  
The Mediterranean

scholarly journals Mediterranean Diet Effects on Type 2 Diabetes Prevention, Disease Progression, and Related Mechanisms. A Review

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2236 ◽  
Author(s):  
Sandra Martín-Peláez ◽  
Montse Fito ◽  
Olga Castaner
Keyword(s):  
Type 2 Diabetes ◽  
Mediterranean Diet ◽  
Healthy Lifestyle ◽  
Diabetes Type 2 ◽  
Antioxidant Compounds ◽  
Published Evidence ◽  
Quality Diet ◽  
The Mediterranean ◽  
Traditional Mediterranean Diet

The search for a quality diet has grown over the past decade. Diet is considered one of the pillars for the prevention and progression of several diseases, among them: diabetes. Type 2 diabetes (T2D) is an epidemic of western countries that increases the vulnerability of other diseases, such as cardiovascular and cancer. T2D is associated with lifestyle and diet. The traditional Mediterranean diet has proven its benefits over several cardiovascular risk factors, and specifically on diabetes. This review compiles recent published evidence on the effects of the Mediterranean diet on the incidence and progression of type 2 diabetes (T2D) and its relation with several other cardiovascular healthy diets. We will also focus on how the Mediterranean diet could play a role in T2D-related mechanisms, such as anti-inflammatory or antioxidant compounds, glucagon-like peptide agonist compounds, and changes in gut microbiota. Each component of the Mediterranean diet could be involved in processes related to diabetes homeostasis, many of them sharing common physio-pathological pathways. The importance of this diet within the set of habits of a healthy lifestyle must be emphasized.

scholarly journals May the Mediterranean diet attenuate the risk of type 2 diabetes associated with obesity: the Seguimiento Universidad de Navarra (SUN) cohort

2017 ◽  
Vol 117 (10) ◽  
pp. 1478-1485 ◽  
Author(s):  
Sonia Eguaras ◽  
Maira Bes-Rastrollo ◽  
Miguel Ruiz-Canela ◽  
Silvia Carlos ◽  
Pedro de la Rosa ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adverse Effects ◽  
Mediterranean Diet ◽  
Weight Changes ◽  
Product Term ◽  
Hazard Ratios ◽  
The Mediterranean ◽  
Incident Cases

AbstractIt is likely that the Mediterranean diet (MedDiet) may mitigate the adverse effects of obesity on the incidence of type 2 diabetes mellitus (T2DM). We assessed this hypothesis in a cohort of 18 225 participants initially free of diabetes (mean age: 38 years, 61 % women). A validated semi-quantitative 136-item FFQ was used to assess dietary intake and to build a 0–9 score of adherence to MedDiet. After a median of 9·5-year follow-up, 136 incident cases of T2DM were confirmed during 173 591 person-years follow-up. When MedDiet adherence was low (≤4 points), the multivariable-adjusted hazard ratios (HR) were 4·07 (95 % CI 1·58, 10·50) for participants with BMI 25–29·99 kg/m2 and 17·70 (95 % CI 6·29, 49·78) kg/m2 for participants with BMI≥30 kg/m2, (v.<25 kg/m2). In the group with better adherence to the MedDiet (>4 points), these multivariable-adjusted HR were 3·13 (95 % CI 1·63, 6·01) and 10·70 (95 % CI 4·98, 22·99) for BMI 25–30 and ≥30 kg/m2, respectively. The P value for the interaction was statistically significant (P=0·002). When we assessed both variables (BMI and MedDiet) as continuous, the P value for their interaction product-term was marginally significant (P=0·051) in fully adjusted models. This effect modification was not explained by weight changes during follow-up. Our results suggest that the MedDiet may attenuate the adverse effects of obesity on the risk of T2DM.

scholarly journals Dietary Polyphenols, Mediterranean Diet, Prediabetes, and Type 2 Diabetes: A Narrative Review of the Evidence

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Marta Guasch-Ferré ◽  
Jordi Merino ◽  
Qi Sun ◽  
Montse Fitó ◽  
Jordi Salas-Salvadó
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Mediterranean Diet ◽  
Prospective Studies ◽  
Food Sources ◽  
Dietary Polyphenols ◽  
Beneficial Effects ◽  
The Mediterranean ◽  
Polyphenol Intake

Dietary polyphenols come mainly from plant-based foods including fruits, vegetables, whole grains, coffee, tea, and nuts. Polyphenols may influence glycemia and type 2 diabetes (T2D) through different mechanisms, such as promoting the uptake of glucose in tissues, and therefore improving insulin sensitivity. This review aims to summarize the evidence from clinical trials and observational prospective studies linking dietary polyphenols to prediabetes and T2D, with a focus on polyphenol-rich foods characteristic of the Mediterranean diet. We aimed to describe the metabolic biomarkers related to polyphenol intake and genotype-polyphenol interactions modulating the effects on T2D. Intakes of polyphenols, especially flavan-3-ols, and their food sources have demonstrated beneficial effects on insulin resistance and other cardiometabolic risk factors. Several prospective studies have shown inverse associations between polyphenol intake and T2D. The Mediterranean diet and its key components, olive oil, nuts, and red wine, have been inversely associated with insulin resistance and T2D. To some extent, these associations may be attributed to the high amount of polyphenols and bioactive compounds in typical foods conforming this traditional dietary pattern. Few studies have suggested that genetic predisposition can modulate the relationship between polyphenols and T2D risk. In conclusion, the intake of polyphenols may be beneficial for both insulin resistance and T2D risk.

Adherence to the Mediterranean Diet in Patients with Type 2 Diabetes Mellitus and HbA1c Level

2011 ◽  
Vol 58 (1) ◽  
pp. 74-78 ◽  
Author(s):  
Javier Díez-Espino ◽  
Pilar Buil-Cosiales ◽  
Manuel Serrano-Martínez ◽  
Estefanía Toledo ◽  
Jordi Salas-Salvadó ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mediterranean Diet ◽  
Hba1c Level ◽  
The Mediterranean

scholarly journals Circulating Adiponectin and Its Association with Metabolic Traits and Type 2 Diabetes: Gene-Diet Interactions Focusing on Selected Gene Variants and at the Genome-Wide Level in High-Cardiovascular Risk Mediterranean Subjects

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 541
Author(s):  
Oscar Coltell ◽  
Carolina Ortega-Azorín ◽  
Jose V. Sorlí ◽  
Olga Portolés ◽  
Eva M. Asensio ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Mediterranean Diet ◽  
Mediterranean Population ◽  
High Cardiovascular Risk ◽  
Plasma Adiponectin ◽  
Metabolic Traits ◽  
Genome Wide ◽  
The Mediterranean

Adiponectin is gaining renewed interest since, in addition to its possible protective role against insulin resistance and arteriosclerosis, recent studies suggest other additional favorable effects. However, the influence of gene-diet interactions on plasma adiponectin levels is still little understood. We analyzed the association between plasma adiponectin levels and various metabolic traits in a high-cardiovascular risk Mediterranean population, as well as the genetic effect of four candidate single-nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) and their interactions with the Mediterranean dietary pattern. Additionally, we explored, at the genome-wide level, the SNPs most associated with plasma adiponectin levels, as well as gene–diet interactions with the Mediterranean diet. In the 954 participants studied (aged 55–80 years), plasma adiponectin levels were strongly associated with plasma HDL-C concentrations (p = 6.6 × 10−36) and inversely related to triglycerides (p = 4.7 × 10−18), fasting glucose (p = 3.5 × 10−16) and type 2 diabetes (p = 1.4 × 10−7). Of the four pre-selected ADIPOQ candidate SNPs, the one most associated with plasma adiponectin was the −11391G > A (rs17300539) promoter SNP (p = 7.2 × 10−5, in the multivariable adjusted model). No significant interactions with the Mediterranean diet pattern were observed for these SNPs. Additionally, in the exploratory genome-wide association study (GWAS), we found new SNPs associated with adiponectin concentrations at the suggestive genome-wide level (p < 1 × 10−5) for the whole population, including the lead SNP rs9738548 (intergenic) and rs11647294 in the VAT1L (Vesicle Amine Transport 1 Like) gene. We also found other promising SNPs on exploring different strata such as men, women, diabetics and non-diabetics (p = 3.5 × 10−8 for rs2850066). Similarly, we explored gene–Mediterranean diet interactions at the GWAS level and identified several SNPs with gene–diet interactions at p < 1 × 10−5. A remarkable gene–diet interaction was revealed for the rs2917570 SNP in the OPCML (Opioid Binding Protein/Cell Adhesion Molecule Like) gene, previously reported to be associated with adiponectin levels in some populations. Our results suggest that, in this high-cardiovascular risk Mediterranean population, and even though adiponectin is favorably associated with metabolic traits and lower type 2 diabetes, the gene variants more associated with adiponectin may be population-specific, and some suggestive gene–Mediterranean diet interactions were detected.

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