scholarly journals The Role of Blood Pressure Variability in the Development of Nephropathy in Type 1 Diabetes

Diabetes Care ◽  
2010 ◽  
Vol 33 (11) ◽  
pp. 2442-2447 ◽  
Author(s):  
E. S. Kilpatrick ◽  
A. S. Rigby ◽  
S. L. Atkin
Keyword(s):  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Blood Pressure Variability

scholarly journals Role of blood pressure in development of early retinopathy in adolescents with type 1 diabetes: prospective cohort study

BMJ ◽  
2008 ◽  
Vol 337 (aug26 1) ◽  
pp. a918-a918 ◽  
Author(s):  
P. H. Gallego ◽  
M. E Craig ◽  
S. Hing ◽  
K. C Donaghue
Keyword(s):  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort

scholarly journals The role of blood pressure in risk of ischemic and hemorrhagic stroke in type 1 diabetes

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Stefanie Hägg-Holmberg ◽  
◽  
Emma H. Dahlström ◽  
Carol M. Forsblom ◽  
Valma Harjutsalo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Hemorrhagic Stroke

Early atherosclerosis in childhood type 1 diabetes: role of raised systolic blood pressure in the absence of dyslipidaemia

2007 ◽  
Vol 166 (6) ◽  
pp. 541-548 ◽  
Author(s):  
Karl Otfried Schwab ◽  
Jürgen Doerfer ◽  
Andreas Krebs ◽  
Kristin Krebs ◽  
Elisabeth Schorb ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Systolic Blood Pressure ◽  
Childhood Type 1 Diabetes ◽  
Childhood Type ◽  
Early Atherosclerosis

scholarly journals Role of Nox2 in diabetic kidney disease

2013 ◽  
Vol 304 (7) ◽  
pp. F840-F848 ◽  
Author(s):  
Young-Hyun You ◽  
Shinichi Okada ◽  
San Ly ◽  
Karin Jandeleit-Dahm ◽  
David Barit ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Kidney Disease ◽  
Systolic Blood Pressure ◽  
Diabetic Kidney Disease ◽  
Microvascular Complications ◽  
Macrophage Infiltration ◽  
Diabetic Kidney

NADPH oxidase (Nox) isoforms have been implicated in contributing to diabetic microvascular complications, but the functional role of individual isoforms in diabetic kidney are unclear. Nox2, in particular, is highly expressed in phagocytes and may play a key inflammatory role in diabetic kidney disease. To determine the role of Nox2, we evaluated kidney function and pathology in wild-type (WT; C57BL/6) and Nox2 knockout (KO) mice with type 1 diabetes. Diabetes was induced in male Nox2 KO and WT mice with a multiple low-dose streptozotocin protocol. Groups were studied for kidney disease after 8 and 20 wk of diabetes. Hyperglycemia and body weights were similar in WT and Nox2 KO diabetic mice. All functional and structural features of early and later stage diabetic kidney disease (albuminuria, mesangial matrix, tubulointerstitial disease, and gene expression of matrix and transforming growth factor-β) were similar in both diabetic groups compared with their respective nondiabetic groups, except for reduction of macrophage infiltration and monocyte chemoattractant protein-1 in the diabetic Nox2 KO mice. Systolic blood pressure by telemetry was surprisingly increased in Nox2 KO mice; however, the systolic blood pressure was reduced in the diabetic WT and Nox2 KO mice by tail-cuff. Interestingly, diabetic Nox2 KO mice had marked upregulation of renal Nox4 at both the glomerular and cortical levels. The present results demonstrate that lack of Nox2 does not protect against diabetic kidney disease in type 1 diabetes, despite a reduction in macrophage infiltration. The lack of renoprotection may be due to upregulation of renal Nox4.

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