scholarly journals Acute Pancreatitis in Association With Type 2 Diabetes and Antidiabetic Drugs: A population-based cohort study

Diabetes Care ◽  
2010 ◽  
Vol 33 (12) ◽  
pp. 2580-2585 ◽  
Author(s):  
A. Gonzalez-Perez ◽  
R. G. Schlienger ◽  
L. A. G. Rodriguez
Keyword(s):  
Type 2 Diabetes ◽  
Acute Pancreatitis ◽  
Cohort Study ◽  
Population Based ◽  
Antidiabetic Drugs

scholarly journals Incretin based drugs and risk of cholangiocarcinoma among patients with type 2 diabetes: population based cohort study

BMJ ◽  
2018 ◽  
pp. k4880 ◽  
Author(s):  
Devin Abrahami ◽  
Antonios Douros ◽  
Hui Yin ◽  
Oriana HY Yu ◽  
Jean-Luc Faillie ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Confidence Interval ◽  
Population Based ◽  
Hazard Ratio ◽  
Antidiabetic Drugs ◽  
Receptor Agonists ◽  
Increased Risk ◽  
Third Line

AbstractObjectiveTo determine whether use of dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists are associated with an increased risk of cholangiocarcinoma in adults with type 2 diabetes.DesignPopulation based cohort study.SettingGeneral practices contributing data to the UK Clinical Practice Research Datalink.Participants154 162 adults newly treated with antidiabetic drugs between 1 January 2007 and 31 March 2017, followed until 31 March 2018.Main outcome measuresUse of DPP-4 inhibitors and GLP-1 receptor agonists was modelled as a time varying variable and compared with use of other second or third line antidiabetic drugs. All exposures were lagged by one year to account for cancer latency and to minimise reverse causality. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals of incident cholangiocarcinoma associated with use of DPP-4 inhibitors and GLP-1 receptor agonists, separately. A post hoc pharmacovigilance analysis was conducted using the World Health Organization’s global individual case safety report database, VigiBase, to estimate reporting odds ratios of cholangiocarcinoma.ResultsDuring 614 274 person years of follow-up, 105 incident cholangiocarcinoma events occurred (rate 17.1 per 100 000 person years). Use of DPP-4 inhibitors was associated with a 77% increased hazard of cholangiocarcinoma (hazard ratio 1.77, 95% confidence interval 1.04 to 3.01). Use of GLP-1 receptor agonists was associated with an increased hazard with a wide confidence interval (hazard ratio 1.97, 0.83 to 4.66). In the pharmacovigilance analysis, the use of DPP-4 inhibitors and GLP-1 receptor agonists were both associated with increased reporting odds ratios for cholangiocarcinoma, compared with use of sulfonylureas or thiazolidinediones (1.63, 1.00 to 2.66, 4.73, 2.95 to 7.58, respectively).ConclusionCompared with use of other second or third line antidiabetic drugs, use of DPP-4 inhibitors, and possibly GLP-1 receptor agonists, might be associated with an increased risk of cholangiocarcinoma in adults with type 2 diabetes.

Risk of Acute Pancreatitis in Type 2 Diabetes and Risk Reduction on Anti-Diabetic Drugs: A Population-Based Cohort Study in Taiwan

2011 ◽  
Vol 106 (9) ◽  
pp. 1697-1704 ◽  
Author(s):  
Shih-Wei Lai ◽  
Chih-Hsin Muo ◽  
Kuan-Fu Liao ◽  
Fung-Chang Sung ◽  
Pei-Chun Chen
Keyword(s):  
Type 2 Diabetes ◽  
Acute Pancreatitis ◽  
Cohort Study ◽  
Risk Reduction ◽  
Population Based

115 RISK OF POST-COLONOSCOPY COLORECTAL CANCER IN PATIENTS WITH TYPE 2 DIABETES MELLITUS: A DANISH POPULATION-BASED COHORT STUDY

2021 ◽  
Vol 160 (6) ◽  
pp. S-30
Author(s):  
Frederikke Sch⊘nfeldt Troelsen ◽  
Henrik Toft S⊘rensen ◽  
Lars Pedersen ◽  
Rune Erichsen
Keyword(s):  
Diabetes Mellitus ◽  
Colorectal Cancer ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cohort Study ◽  
Population Based ◽  
Danish Population

Risk of type 2 diabetes in patients with insomnia: A population-based historical cohort study

2017 ◽  
Vol 34 (1) ◽  
pp. e2930 ◽  
Author(s):  
Chia-Ling Lin ◽  
Wu-Chien Chien ◽  
Chi-Hsiang Chung ◽  
Fei-Ling Wu
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Population Based ◽  
Historical Cohort ◽  
Historical Cohort Study
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