scholarly journals Urine Proteome Analysis May Allow Noninvasive Differential Diagnosis of Diabetic Nephropathy

Diabetes Care ◽  
2010 ◽  
Vol 33 (11) ◽  
pp. 2409-2415 ◽  
Author(s):  
M. Papale ◽  
S. Di Paolo ◽  
R. Magistroni ◽  
O. Lamacchia ◽  
A. M. Di Palma ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Diabetic Nephropathy ◽  
Proteome Analysis ◽  
Urine Proteome

Reconstruction of associative protein networks connected with processes of sodium exchange regulation and sodium deposition in healthy volunteers based on urine proteome analysis

2012 ◽  
Vol 38 (3) ◽  
pp. 316-323 ◽  
Author(s):  
I. M. Larina ◽  
N. A. Kolchanov ◽  
I. V. Dobrokhotov ◽  
V. A. Ivanisenko ◽  
P. S. Demenkov ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Proteome Analysis ◽  
Protein Networks ◽  
Urine Proteome ◽  
Sodium Exchange

Toward a standardized urine proteome analysis methodology

2011 ◽  
Vol 5 (9-10) ◽  
pp. 547-547 ◽  
Author(s):  
Magali Court ◽  
Nathalie Selevsek ◽  
Mariette Matondo ◽  
Yves Allory ◽  
Jerome Garin ◽  
...  
Keyword(s):  
Proteome Analysis ◽  
Urine Proteome ◽  
Analysis Methodology

Accurate mass tag retention time database for urine proteome analysis by chromatography-mass spectrometry

2010 ◽  
Vol 75 (5) ◽  
pp. 636-641 ◽  
Author(s):  
I. A. Agron ◽  
D. M. Avtonomov ◽  
A. S. Kononikhin ◽  
I. A. Popov ◽  
S. A. Moshkovskii ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Retention Time ◽  
Proteome Analysis ◽  
Accurate Mass ◽  
Urine Proteome ◽  
Tag Retention ◽  
Chromatography Mass Spectrometry ◽  
Mass Tag

Toward a standardized urine proteome analysis methodology

PROTEOMICS ◽  
2011 ◽  
Vol 11 (6) ◽  
pp. 1160-1171 ◽  
Author(s):  
Magali Court ◽  
Nathalie Selevsek ◽  
Mariette Matondo ◽  
Yves Allory ◽  
Jerome Garin ◽  
...  
Keyword(s):  
Proteome Analysis ◽  
Urine Proteome ◽  
Analysis Methodology

scholarly journals Urinary Proteome Analysis Identified Neprilysin and VCAM as Proteins Involved in Diabetic Nephropathy

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Elena Guillén-Gómez ◽  
Beatriz Bardají-de-Quixano ◽  
Sílvia Ferrer ◽  
Carlos Brotons ◽  
Mark A. Knepper ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Proteome Analysis ◽  
Sample Collection ◽  
Urinary Proteome ◽  
Modeling Analysis ◽  
Tandem Mass Tag ◽  
Type 2 Diabetic ◽  
Losartan Treatment ◽  
Differentially Abundant Proteins

Urinary proteome was analyzed and quantified by tandem mass tag (TMT) labeling followed by bioinformatics analysis to study diabetic nephropathy (DN) pathophysiology and to identify biomarkers of a clinical outcome. We included type 2 diabetic normotensive non-obese males with (n=9) and without (n=11) incipient DN (microalbuminuria). Sample collection included blood and urine at baseline (control and DN basal) and, in DN patients, after 3 months of losartan treatment (DN treated). Urinary proteome analysis identified 166 differentially abundant proteins between controls and DN patients, 27 comparing DN-treated and DN-basal patients, and 182 between DN-treated patients and controls. The mathematical modeling analysis predicted 80 key proteins involved in DN pathophysiology and 15 in losartan effect, a total of 95 proteins. Out of these 95, 7 are involved in both processes. VCAM-1 and neprilysin stand out of these 7 for being differentially expressed in the urinary proteome. We observed an increase of VCAM-1 urine levels in DN-basal patients compared to diabetic controls and an increase of urinary neprilysin in DN-treated patients with persistent albuminuria; the latter was confirmed by ELISA. Our results point to neprilysin and VCAM-1 as potential candidates in DN pathology and treatment.

scholarly journals Plasma proteome analysis of patients with type 1 diabetes with diabetic nephropathy

2010 ◽  
Vol 8 (1) ◽  
pp. 4 ◽  
Author(s):  
Anne Overgaard ◽  
Henning Hansen ◽  
Maria Lajer ◽  
Lykke Pedersen ◽  
Lise Tarnow ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Proteome Analysis ◽  
Plasma Proteome

Urine proteome analysis in Dent's disease shows high selective changes potentially involved in chronic renal damage

2016 ◽  
Vol 130 ◽  
pp. 26-32 ◽  
Author(s):  
Laura Santucci ◽  
Giovanni Candiano ◽  
Franca Anglani ◽  
Maurizio Bruschi ◽  
Enrica Tosetto ◽  
...  
Keyword(s):  
Renal Damage ◽  
Proteome Analysis ◽  
Dent’S Disease ◽  
Urine Proteome ◽  
Dent's Disease
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