scholarly journals High-Normal Serum Uric Acid Increases Risk of Early Progressive Renal Function Loss in Type 1 Diabetes: Results of a 6-year follow-up

Diabetes Care ◽  
2010 ◽  
Vol 33 (6) ◽  
pp. 1337-1343 ◽  
Author(s):  
L. H. Ficociello ◽  
E. T. Rosolowsky ◽  
M. A. Niewczas ◽  
N. J. Maselli ◽  
J. M. Weinberg ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Renal Function ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Normal Serum ◽  
Function Loss

scholarly journals High-Normal Serum Uric Acid Is Associated with Impaired Glomerular Filtration Rate in Nonproteinuric Patients with Type 1 Diabetes

2008 ◽  
Vol 3 (3) ◽  
pp. 706-713 ◽  
Author(s):  
Elizabeth T. Rosolowsky ◽  
Linda H. Ficociello ◽  
Nicholas J. Maselli ◽  
Monika A. Niewczas ◽  
Amanda L. Binns ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Uric Acid ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Serum Uric Acid ◽  
Filtration Rate ◽  
Normal Serum

scholarly journals Serum uric acid and renal function in patients with type 1 diabetes: a nationwide study in Brazil

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Marcela Haas Pizarro ◽  
Deborah Conte Santos ◽  
Bianca Senger Vasconcelos Barros ◽  
Laura Gomes Nunes de Melo ◽  
Marilia Brito Gomes
Keyword(s):  
Type 1 Diabetes ◽  
Renal Function ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Nationwide Study

scholarly journals Serum uric acid and insulin sensitivity in adolescents and adults with and without type 1 diabetes

2014 ◽  
Vol 28 (3) ◽  
pp. 298-304 ◽  
Author(s):  
Petter Bjornstad ◽  
Janet K. Snell-Bergeon ◽  
Kimberly McFann ◽  
R. Paul Wadwa ◽  
Marian Rewers ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Uric Acid ◽  
Insulin Sensitivity ◽  
Serum Uric Acid ◽  
Adolescents And Adults

scholarly journals The serum uric acid concentration is not causally linked to diabetic nephropathy in type 1 diabetes

2017 ◽  
Vol 91 (5) ◽  
pp. 1178-1185 ◽  
Author(s):  
Aila J. Ahola ◽  
Niina Sandholm ◽  
Carol Forsblom ◽  
Valma Harjutsalo ◽  
Emma Dahlström ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Uric Acid ◽  
Diabetic Nephropathy ◽  
Serum Uric Acid ◽  
Acid Concentration ◽  
Uric Acid Concentration ◽  
Serum Uric Acid Concentration

scholarly journals Chicken uric acid elimination via the uric acid transporters BCRP and MRP4 in the liver, kidneys, and intestines

2018 ◽  
Author(s):  
Xuedong Ding ◽  
Manman Li ◽  
Shoufa Qian ◽  
Yuying Ma ◽  
Tianyi Fang ◽  
...  
Keyword(s):  
Renal Function ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Normal Serum ◽  
Control Group ◽  
Cancer Resistance ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
Resistance Protein ◽  
Treated Drinking Water

AbstractBreast cancer resistance protein (BCRP) and multidrug resistance protein 4 (MRP4) are involved in uric acid excretion in humans and mice. Despite evidence suggesting that chicken renal proximal tubular epithelial cells participate in uric acid secretion, the roles of BCRP and MRP4 in chickens remain unclear. This study evaluated the relationship between chicken BCRP and MRP4 expression and renal function in the liver, kidneys, and intestines. Sixty 20-day-old Isa brown laying hens were randomly divided into four groups: a control group (NC) and groups provided with sulfonamide-treated drinking water (SD), a diet supplemented with fishmeal (FM), and an intraperitoneal injection of uric acid (IU). Serum uric acid, creatinine, and blood urea nitrogen (BUN) levels were significantly higher in the SD and IU groups than in the NC group. BCRP and MRP4 levels in the SD and IU groups were significantly increased in the kidneys and ileum and decreased in the liver. In the FM group, BCRP and MRP4 were significantly increased in the kidneys and slightly increased in the ileum. These results demonstrate that chicken BCRP and MRP4 are involved in renal and intestinal uric acid excretion. When renal function is impaired, serum uric acid increased and BCRP and MRP4 in the liver, kidneys, and ileum exhibit compensatory increases; when renal function is normal, serum uric acid changes have no effect on ileum BCRP and MRP4 expression. Therefore, this study may provide the references to the uric acid regulation in human.

Serum uric acid and progression of diabetic nephropathy in type 1 diabetes

2018 ◽  
Vol 32 (5) ◽  
pp. 470-473 ◽  
Author(s):  
S. Pilemann-Lyberg ◽  
M. Lindhardt ◽  
Frederik Persson ◽  
S. Andersen ◽  
P. Rossing
Keyword(s):  
Type 1 Diabetes ◽  
Uric Acid ◽  
Diabetic Nephropathy ◽  
Serum Uric Acid

scholarly journals Reference interval and upper decission limit for serum uric acid – an evidence-based approach on Romanian population using an a posteriori method

2019 ◽  
Vol 27 (2) ◽  
pp. 147-158
Author(s):  
Catalin Codreanu ◽  
Horatiu Popoviciu ◽  
Elena Rezus ◽  
Corina Delia Mogosan ◽  
Ioannis Gardikiotis ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Reference Interval ◽  
Reference Intervals ◽  
Normal Serum ◽  
Least Square ◽  
Unique Type ◽  
Normal Individuals ◽  
Gender Specific

Abstract Introduction. There is accumulating evidence that high normal serum uric acid (SUA) levels of 6-7 mg/dL are associated with cardiovascular morbidity and metabolic syndrome (MetS), hence the need to redefine its upper limit of normal (ULN). We aimed to derive ULN based on statistics and evidence in a representative sample of the population and to observe its relation to MetS components. Methods. All SUA measurements form a university rheumatology hospital were extracted between January 5th 2010 and March 21st 2018. SUA levels were measured by a single biochemist a unique type of commercially available kit. Follow-up measurements, patients with diagnoses influencing SUA levels and outlying measurements were excluded. ULNs were studied using least square analysis. Results. Of the 22503 SUA measurements in the database, only 3318 came from normal individuals: 33.3% men (n=1105), 66.7% women (n = 2213). Least square analysis revealed the following SUA reference intervals (RI): 3.43-6.19 mg/dL for the combined sample; 4.44-7.01 mg/dL for men, 3.28-5.56 mg/dL for women. The values corresponding to the 66th percentile of each group presented lower ULNs: 5.36 mg/dL for all, 6.10 mg/dL for men, 4.90 mg/dL for women. The prevalence of hyperuricemia increased from 13.8% (manufacturer’s gender-specific ULN) to 19.9% (derived ULN). Mean SUA levels significantly increased with the number of MetS components. Conclusion. We recommend that hyperuricemia should be defined using a statistical approach of ULN selection corresponding to the genderand population-specific 66th percentile of data range.

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