scholarly journals Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

Diabetes Care ◽  
2009 ◽  
Vol 32 (suppl_2) ◽  
pp. S157-S163 ◽  
Author(s):  
R. A. DeFronzo ◽  
D. Tripathy
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Primary Defect ◽  
Muscle Insulin Resistance ◽  
Skeletal Muscle Insulin Resistance

scholarly journals Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance

Diabetes ◽  
2012 ◽  
Vol 62 (2) ◽  
pp. 401-410 ◽  
Author(s):  
J. Boon ◽  
A. J. Hoy ◽  
R. Stark ◽  
R. D. Brown ◽  
R. C. Meex ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Muscle Insulin Resistance ◽  
Skeletal Muscle Insulin Resistance

Antioxidant supplemention in the treatment of skeletal muscle insulin resistance: potential mechanisms and clinical relevance

2008 ◽  
Vol 33 (1) ◽  
pp. 21-31 ◽  
Author(s):  
David Wright ◽  
Lindsey Sutherland
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Glucose Homeostasis ◽  
Whole Body ◽  
Antioxidant Compounds ◽  
Muscle Insulin Resistance ◽  
Beneficial Effects ◽  
Skeletal Muscle Insulin Resistance

The incidence of type 2 diabetes has increased dramatically over the past several decades and this trend is projected to continue into the foreseeable future. Skeletal muscle insulin resistance is thought to be a key development in the pathogenesis of type 2 diabetes. Given this fact, interventions that prevent or reverse impairments in skeletal muscle action can have profound effects on whole-body glucose homeostasis. Traditional approaches used in this regard include exercise, weight loss, and insulin-sensitizing drugs such as thiazolidinediones (TZDs). Although these interventions have proven effective in improving glucose homeostasis, there are adherence issues seen with lifestyle interventions and undesirable side effects have been reported with TZDs. With these points in mind, the development of alternative strategies to maintain or improve skeletal muscle insulin sensitivity is warranted. In this context, the purpose of the present review is to highlight the role of antioxidant compounds in the prevention and treatment of skeletal muscle insulin resistance. Specifically, we will briefly describe the mechanisms of insulin-stimulated skeletal muscle glucose uptake and the potential mediators of oxidative stress induced insulin resistance, highlight data suggesting that antioxidant compounds can have beneficial effects on skeletal muscle insulin action, and discuss potential mechanisms mediating this effect.

scholarly journals Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes

Diabetes ◽  
2000 ◽  
Vol 49 (2) ◽  
pp. 263-271 ◽  
Author(s):  
S. E. Nikoulina ◽  
T. P. Ciaraldi ◽  
S. Mudaliar ◽  
P. Mohideen ◽  
L. Carter ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Potential Role ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase 3 ◽  
Muscle Insulin Resistance ◽  
Skeletal Muscle Insulin Resistance
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