scholarly journals Pioglitazone Decreases Plasma Cholesteryl Ester Transfer Protein Mass, Associated With a Decrease in Hepatic Triglyceride Content, in Patients With Type 2 Diabetes

Diabetes Care ◽  
2010 ◽  
Vol 33 (7) ◽  
pp. 1625-1628 ◽  
Author(s):  
J. T. Jonker ◽  
Y. Wang ◽  
W. de Haan ◽  
M. Diamant ◽  
L. J. Rijzewijk ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Hepatic Triglyceride ◽  
Protein Mass ◽  
Transfer Protein ◽  
Plasma Cholesteryl Ester ◽  
Triglyceride Content

scholarly journals Cholesteryl Ester Transfer Protein Genetic Variants Associated with Risk for Type 2 Diabetes and Diabetic Kidney Disease in Taiwanese Population

Genes ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 782 ◽  
Author(s):  
Huang ◽  
Chen ◽  
Liu ◽  
Lin ◽  
Lin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Kidney Disease ◽  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Diabetic Kidney Disease ◽  
Density Lipoprotein ◽  
Diabetic Kidney ◽  
Transfer Protein ◽  
Low Levels

Cholesteryl ester transfer protein (CETP) plays an important role in lipid metabolism. Low levels of high-density lipoprotein cholesterol (HDL-C) increase the risk of type 2 diabetes (T2D). This study investigated CETP gene variants to assess the risk of T2D and specific complications of diabetic kidney disease (DKD) and diabetic retinopathy. Towards this, a total of 3023 Taiwanese individuals (1383 without T2D, 1640 with T2D) were enrolled in this study. T2D mice (+Leprdb/+Leprdb, db/db) were used to determine CETP expression in tissues. The A-alleles of rs3764261, rs4783961, and rs1800775 variants were found to be independently associated with 2.86, 1.71, and 0.91 mg/dL increase in HDL-C per allele, respectively. In addition, the A-allele of rs4783961 was significantly associated with a reduced T2D risk (odds ratio (OR), 0.82; 95% confidence interval (CI), 0.71‒0.96)), and the A-allele of rs1800775 was significantly related to a lowered DKD risk (OR, 0.78; 95% CI, 0.64‒0.96). CETP expression was significantly decreased in the T2D mice kidney compared to that in the control mice (T2D mice, 0.16 0.01 vs. control mice, 0.21 0.02; p = 0.02). These collective findings indicate that CETP variants in the promoter region may affect HDL-C levels. Taiwanese individuals possessing an allele associated with higher HDL-C levels had a lower risk of T2D and DKD.

scholarly journals Common Cholesteryl Ester Transfer Protein Gene Polymorphisms and the Effect of Atorvastatin Therapy in Type 2 Diabetes

Diabetes Care ◽  
2003 ◽  
Vol 26 (4) ◽  
pp. 1216-1223 ◽  
Author(s):  
F. V. van Venrooij ◽  
R. P. Stolk ◽  
J.-D. Banga ◽  
T. P. Sijmonsma ◽  
A. van Tol ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Gene Polymorphisms ◽  
Protein Gene ◽  
Transfer Protein ◽  
Atorvastatin Therapy

Cholesteryl ester transfer protein polymorphism associated with macroangiopathy in Japanese patients with type 2 diabetes

2001 ◽  
Vol 156 (1) ◽  
pp. 151-156 ◽  
Author(s):  
Shu Meguro ◽  
Izumi Takei ◽  
Mitsuru Murata ◽  
Hiroshi Hirose ◽  
Naoyuki Takei ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Japanese Patients ◽  
Protein Polymorphism ◽  
Transfer Protein

Influence of menopause and cholesteryl ester transfer protein (CETP) TaqIB polymorphism on lipid profile and HDL subpopulations distribution in women with and without type 2 diabetes

2010 ◽  
Vol 210 (1) ◽  
pp. 294-301 ◽  
Author(s):  
Giuseppina T. Russo ◽  
Kathleen V. Horvath ◽  
Antonino Di Benedetto ◽  
Annalisa Giandalia ◽  
Domenico Cucinotta ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cholesteryl Ester ◽  
Lipid Profile ◽  
Cholesteryl Ester Transfer Protein ◽  
Transfer Protein
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