scholarly journals Effect of Ezetimibe on Hepatic Fat, Inflammatory Markers, and Apolipoprotein B-100 Kinetics in Insulin-Resistant Obese Subjects on a Weight Loss Diet

Diabetes Care ◽  
2010 ◽  
Vol 33 (5) ◽  
pp. 1134-1139 ◽  
Author(s):  
D. C. Chan ◽  
G. F. Watts ◽  
S. K. Gan ◽  
E. M. M. Ooi ◽  
P. H. R. Barrett
Keyword(s):  
Weight Loss ◽  
Apolipoprotein B ◽  
Inflammatory Markers ◽  
Insulin Resistant ◽  
Weight Loss Diet ◽  
Hepatic Fat ◽  
Obese Subjects

Effects of a Low Carbohydrate Weight Loss Diet on Exercise Capacity and Tolerance in Obese Subjects

Obesity ◽  
2009 ◽  
Author(s):  
Grant D. Brinkworth ◽  
Manny Noakes ◽  
Peter M. Clifton ◽  
Jonathan D. Buckley
Keyword(s):  
Weight Loss ◽  
Exercise Capacity ◽  
Weight Loss Diet ◽  
Low Carbohydrate ◽  
Obese Subjects

scholarly journals Serum and urinary concentrations of calprotectin as markers of insulin resistance and type 2 diabetes

2012 ◽  
Vol 167 (4) ◽  
pp. 569-578 ◽  
Author(s):  
Francisco J Ortega ◽  
Mónica Sabater ◽  
José M Moreno-Navarrete ◽  
Neus Pueyo ◽  
Patricia Botas ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Weight Loss ◽  
Lipid Metabolism ◽  
Inflammatory Markers ◽  
Low Grade ◽  
Model Assessment ◽  
Glucose And Lipid Metabolism ◽  
Obese Subjects

ObjectiveIncreased circulating calprotectin has been reported in obese subjects but not in association with measures of insulin resistance and type 2 diabetes (T2D). The main aim of this study was to determine whether calprotectins in plasma and urine are associated with insulin resistance.DesignWe performed both cross-sectional and longitudinal (diet-induced weight loss) studies.MethodsCirculating calprotectin concentrations (ELISA), other inflammatory markers, homeostasis model assessment of insulin resistance (HOMA-IR), and parameters of glucose and lipid metabolism were evaluated in 298 subjects (185 with normal (NGT) and 62 with impaired (IGT) glucose tolerance and 51 T2D subjects). Calprotectin was also evaluated in urine samples from 71 participants (50 NGT and 21 subjects with IGT). Insulin sensitivity (SI, Minimal Model) was determined in a subset of 156 subjects, and the effects of weight loss were investigated in an independent cohort of obese subjects (n=19).ResultsCirculating calprotectin was significantly increased in IGT–T2D (independently of BMI) and positively associated with HOMA-IR, obesity measures, inflammatory markers, and parameters of glucose and lipid metabolism. Similar findings were reported for calprotectin concentrations in urine. In the subset of subjects, the association of calprotectin withSIwas independent of BMI and age. In fact,SItogether with C-reactive protein contributed to 27.4% of calprotectin variance after controlling for age and blood neutrophils count. Otherwise, weight loss led to decreased circulating calprotectin in parallel to fasting glucose and HOMA-IR.ConclusionThese findings suggest that circulating and urinary concentrations of calprotectin are linked to chronic low-grade inflammation and insulin resistance beyond obesity.

Exercise training versus diet-induced weight-loss on metabolic risk factors and inflammatory markers in obese subjects: a 12-week randomized intervention study

2010 ◽  
Vol 298 (4) ◽  
pp. E824-E831 ◽  
Author(s):  
Tore Christiansen ◽  
Søren K. Paulsen ◽  
Jens M. Bruun ◽  
Steen B. Pedersen ◽  
Bjørn Richelsen
Keyword(s):  
Gene Expression ◽  
Weight Loss ◽  
Exercise Training ◽  
Inflammatory Markers ◽  
Very Low Energy Diet ◽  
Beneficial Effects ◽  
Weight Losses ◽  
Obese Subjects ◽  
Randomized Intervention Study ◽  
Circulating Inflammatory Markers

The purpose of this study was to investigate the effect of exercise training and diet-induced weight loss alone or in combination on inflammatory markers in circulation, in adipose tissue (AT) and in skeletal muscle (SM) in obese subjects. Seventy-nine obese subjects were randomized into a 12-wk intervention: 1) exercise only (EXO), 2) diet-induced weight loss using a very low energy diet (DIO), and 3) exercise and diet-induced weight-loss combined (DEX). Blood samples (metabolic and inflammatory markers) and AT and SM biopsies (mRNA expression) were collected at baseline and after 12 wk. In the EXO group the weight loss was 3.5 kg and in the DIO and DEX groups it was 12 kg in both. V̇o2max was increased by 14–18% in the EXO and DEX groups with no changes in the DIO group. In the DIO and DEX groups, circulating levels of MCP-1, MIP-1α, IL-15, and IL-18 were decreased, and adiponectin was increased ( P < 0.05 for all). In the EXO group, MCP-1 was decreased with 10% ( P = 0.06). By combining the weight loss in all three groups, we found a correlation between the degree of weight loss and improvement in several of the inflammatory markers ( P < 0.05). In AT biopsies, subjects in the DIO and DEX groups achieved a general beneficial but nonsignificant effect on the gene expression of inflammatory markers. In the EXO group, no changes in AT adipokine mRNA were found except for an increment of adiponectin ( P < 0.05). In SM, the only observed change was that the gene expression of IL-6 was increased in all three groups ( P < 0.05). In conclusion, rather large weight losses (>5–7%) were found to have beneficial effects on circulating inflammatory markers in these obese subjects. Aerobic exercise for 12 wk, which increased V̇o2max, was found to have no effects on circulating inflammatory markers in these obese patients. It is suggested that more intensive exercise may be necessary to affect systemic inflammation.

scholarly journals Hepatic Lipin 1  Expression Is Diminished in Insulin-Resistant Obese Subjects and Is Reactivated by Marked Weight Loss

Diabetes ◽  
2007 ◽  
Vol 56 (9) ◽  
pp. 2395-2399 ◽  
Author(s):  
M. A. Croce ◽  
J. C. Eagon ◽  
L. L. LaRiviere ◽  
K. M. Korenblat ◽  
S. Klein ◽  
...  
Keyword(s):  
Weight Loss ◽  
Insulin Resistant ◽  
Marked Weight ◽  
Lipin 1 ◽  
Obese Subjects

scholarly journals Effects of a Low Carbohydrate Weight Loss Diet on Exercise Capacity and Tolerance in Obese Subjects

Obesity ◽  
2009 ◽  
Vol 17 (10) ◽  
pp. 1916-1923 ◽  
Author(s):  
Grant D. Brinkworth ◽  
Manny Noakes ◽  
Peter M. Clifton ◽  
Jonathan D. Buckley
Keyword(s):  
Weight Loss ◽  
Exercise Capacity ◽  
Weight Loss Diet ◽  
Low Carbohydrate ◽  
Obese Subjects

scholarly journals Impact of weight loss diet associated with flaxseed on inflammatory markers in men with cardiovascular risk factors: a clinical study

2015 ◽  
Vol 14 (1) ◽  
Author(s):  
Roberta Soares Lara Cassani ◽  
Priscila Giacomo Fassini ◽  
Jose Henrique Silvah ◽  
Cristiane Maria Mártires Lima ◽  
Júlio Sérgio Marchini
Keyword(s):  
Risk Factors ◽  
Weight Loss ◽  
Cardiovascular Risk ◽  
Clinical Study ◽  
Cardiovascular Risk Factors ◽  
Inflammatory Markers ◽  
Weight Loss Diet

scholarly journals Retraction Note: Impact of weight loss diet associated with flaxseed on inflammatory markers in men with cardiovascular risk factors: a clinical study

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Roberta Soares Lara Cassani ◽  
Priscila Giacomo Fassini ◽  
Jose Henrique Silvah ◽  
Cristiane Maria Mártires Lima ◽  
Júlio Sérgio Marchini
Keyword(s):  
Risk Factors ◽  
Weight Loss ◽  
Cardiovascular Risk ◽  
Clinical Study ◽  
Cardiovascular Risk Factors ◽  
Inflammatory Markers ◽  
Weight Loss Diet
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