scholarly journals Association of the TNF- -C-857T Polymorphism With Resistance to the Cholesterol-Lowering Effect of HMG-CoA Reductase Inhibitors in Type 2 Diabetic Subjects

Diabetes Care ◽  
2009 ◽  
Vol 33 (3) ◽  
pp. 463-466 ◽  
Author(s):  
T. Takahashi ◽  
K. Takahashi ◽  
M. Yamashina ◽  
C. Maesawa ◽  
T. Kajiwara ◽  
...  
Keyword(s):  
Cholesterol Lowering ◽  
Hmg Coa Reductase ◽  
Lowering Effect ◽  
Reductase Inhibitors ◽  
Hmg Coa Reductase Inhibitors ◽  
Coa Reductase ◽  
Type 2 Diabetic ◽  
Cholesterol Lowering Effect

The effects of pemafibrate in Japanese patients with type 2 diabetes receiving HMG-CoA reductase inhibitors

2020 ◽  
Vol 20 ◽  
Author(s):  
Masataka Kusunoki ◽  
Takahiko Sakazaki ◽  
Kazuhiko Tsutsumi ◽  
Tetsuro Miyata ◽  
Yoshiharu Oshida
Keyword(s):  
Type 2 Diabetes ◽  
Combination Therapy ◽  
Hepatic Dysfunction ◽  
Combination Group ◽  
Hmg Coa Reductase ◽  
Reductase Inhibitors ◽  
Hmg Coa Reductase Inhibitors ◽  
Coa Reductase ◽  
Diabetes Patients

Objective: The combination therapy of HMG-CoA reductase inhibitors (statins), which are anti-hyperlipidemia agents, and fibrates may increase the risk of hepatic dysfunction and myopathy, so this combination required careful administration for patients. In the present study, we evaluated the effects of combination therapy of pemafibrate, a novel fibrate and statins. Methods: We administered pemafibrate for 6 months as an add-on to statin therapy in 27 type 2 diabetes patients with dyslipidemia already receiving statins for 6 months (combination group), and examined the efficacy and safety of the combination therapy in comparison with a pemafibrate monotherapy group. Results: In the combination group, decrease in serum total cholesterol levels was observed after 6 months of pemafibrate treatment compared to baseline, along with increase in HDL-cholesterol. While serum triglyceride level reduced, HbA1c level was elevated in both the groups. Serum creatinine kinase level, which is an indicator of myopathy, was lowered in the combination group. In addition, decrease in -glutamyl transpeptidase, a parameter of hepatic dysfunction, was observed in the combination group. Conclusion: The statin-pemafibrate combination therapy in type 2 diabetes patients with dyslipidemia improved lipid metabolism safely without increasing the risk of hepatic dysfunction and myopathy.

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