scholarly journals Prediction of Type 2 Diabetes Using Alternate Anthropometric Measures in a Multi-Ethnic Cohort: The Insulin Resistance Atherosclerosis Study

Diabetes Care ◽  
2009 ◽  
Vol 32 (5) ◽  
pp. 956-958 ◽  
Author(s):  
M. F. MacKay ◽  
S. M. Haffner ◽  
L. E. Wagenknecht ◽  
R. B. D'Agostino ◽  
A. J.G. Hanley
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Anthropometric Measures ◽  
Insulin Resistance Atherosclerosis Study

scholarly journals Adherence to the DASH Diet Is Inversely Associated With Incidence of Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study

Diabetes Care ◽  
2009 ◽  
Vol 32 (8) ◽  
pp. 1434-1436 ◽  
Author(s):  
A. D. Liese ◽  
M. Nichols ◽  
X. Sun ◽  
R. B. D'Agostino ◽  
S. M. Haffner
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Dash Diet ◽  
Insulin Resistance Atherosclerosis Study

scholarly journals Disposition Index, Glucose Effectiveness, and Conversion to Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study (IRAS)

Diabetes Care ◽  
2010 ◽  
Vol 33 (9) ◽  
pp. 2098-2103 ◽  
Author(s):  
C. Lorenzo ◽  
L. E. Wagenknecht ◽  
M. J. Rewers ◽  
A. J. Karter ◽  
R. N. Bergman ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Disposition Index ◽  
Glucose Effectiveness ◽  
Insulin Resistance Atherosclerosis Study

scholarly journals Longitudinal Decline of β-Cell Function: Comparison of a Direct Method vs a Fasting Surrogate Measure: The Insulin Resistance Atherosclerosis Study

2013 ◽  
Vol 98 (10) ◽  
pp. 4152-4159 ◽  
Author(s):  
A. Festa ◽  
S. M. Haffner ◽  
L. E. Wagenknecht ◽  
C. Lorenzo ◽  
A. J. G. Hanley
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Cell Function ◽  
Fasting Glucose ◽  
Β Cell ◽  
Β Cell Function ◽  
Insulin Resistance Atherosclerosis Study ◽  
Over Time

Abstract Context: β-Cell function (BCF) declines over the course of type 2 diabetes, but little is known about BCF changes across glucose tolerance status (GTS) categories, and comparisons of direct vs surrogate measures. Objective: To assess longitudinal changes in BCF across GTS. Design: The Insulin Resistance Atherosclerosis Study is a multicenter, observational, epidemiologic study. Setting: Four clinical centers in the US that could identify subjects likely to have impaired fasting glucose (IFG) or impaired glucose tolerance (IGT). Patients: We compared longitudinal changes in BCF in 1052 subjects over 5 years. Subjects were categorized according to baseline GTS: normal glucose tolerance (NGT: n = 547), impaired fasting glucose or impaired glucose tolerance (IFG/IGT: n = 341), and newly diagnosed type 2 diabetes (n = 164). Interventions: None. Main Outcome Measures: BCF was assessed from a frequently sampled iv glucose tolerance test (AIR, acute insulin response), and the homeostasis model assessment of BCF (HOMA B). Results: NGT and IFG/IGT subjects increased their insulin secretion over time, whereas those with type 2 diabetes experienced either decline or little change in BCF. After adjustment for demographic variables and change in insulin resistance, change in HOMA B underestimated the magnitude of changes in BCF, as assessed by change in AIR. Relative to NGT, the 5-year change in insulin secretion in IFG/IGT and type 2 diabetes was 31% and 70% lower (by HOMA B) and 50% and 80% lower (by AIR). Conclusions: The decline in BCF over time in IFG/IGT and type 2 diabetes may be more pronounced than previously estimated; HOMA B may underestimate this decline significantly.

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