scholarly journals YKL-40, a Marker of Inflammation and Endothelial Dysfunction, Is Elevated in Patients With Type 1 Diabetes and Increases With Levels of Albuminuria

Diabetes Care ◽  
2008 ◽  
Vol 32 (2) ◽  
pp. 323-328 ◽  
Author(s):  
C. N. Rathcke ◽  
F. Persson ◽  
L. Tarnow ◽  
P. Rossing ◽  
H. Vestergaard
Keyword(s):  
Type 1 Diabetes ◽  
Endothelial Dysfunction

Abstract 344: Endothelin-1 Overexpression Exaggerates Diabetes-induced Endothelial Dysfunction

Hypertension ◽  
2014 ◽  
Vol 64 (suppl_1) ◽  
Author(s):  
Noureddine IDRIS KHODJA ◽  
Muhammad Oneeb Rehman Mian ◽  
Tlili Barhoumi ◽  
Sofiane Ouerd ◽  
Jordan Gornitsky ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Vascular Complications ◽  
Fold Increase ◽  
Wild Type ◽  
No Donor ◽  
Meclofenamic Acid ◽  
Fibronectin Expression ◽  
Endothelium Dependent Relaxation

Objective: Vascular disease associated with endothelial dysfunction is a major cause of morbidity in patients with type-1 diabetes. Endothelin (ET)-1 plays a role in diabetes-induced vascular complications, since ET-1 type A receptor blockade reduces diabetes-induced vascular injury. However, whether ET-1 contributes to diabetes-induced endothelial dysfunction remains unproven. We hypothesized that vascular ET-1 overexpression will exaggerate diabetes-induced endothelial dysfunction. Methods: Diabetes was induced by streptozotocin treatment (STZ, 55 mg/kg/day, ip) for 5 days in 6-week-old male wild-type (WT) mice and in mice overexpressing ET-1 restricted to the endothelium (eET-1). Mice were studied 14 weeks later. Blood was collected to determine glucose. Mesenteric artery reactivity and remodeling were evaluated using pressurized myography and aortic fibronectin expression by immnunofluorescence. Results: STZ-induced diabetes was confirmed by a 3-fold increase in glycemia in WT and eET-1 ( P <0.001). Diabetes impaired endothelium-dependent relaxation (EDR) reponses to acetylcholine in WT (60.9±6.4% vs 83.9±3.4%, P <0.05) and eET-1 (48.6±5.1% vs 81.5±5.2%, P <0.001). EDR impairment was exaggerated in eET-1 compared to WT ( P <0.05). Meclofenamic acid, an inhibitor of cyclooxygenase, increased EDR in eET-1 compared to WT (78.4±9.4% vs 66.7±3.2%, P <0.01), which was not observed in diabetic mice. L-NAME, an inhibitor of nitric oxide (NO) synthase, completely blocked EDR in WT, eET-1 and diabetic WT, but not in diabetic eET-1 (4.1±1.6%, 6.4±5.7%, 2.2±4.6% and 26.6±4.6%, P <0.05). Apamin plus Tram34, inhibitors of endothelium-dependent hyperpolarization inhibited EDR in the four groups. Endothelium-independent relaxation to sodium nitroprusside, a NO donor, was similar in the four groups. Diabetes reduced media/lumen in WT (2.7±0.3 vs 3.6±0.3, P <0.05) and eET-1 (2.9±0.2 vs 3.8±0.3, P <0.05). Diabetes decreased aortic fibronectin expression in WT (94.0±11.0 vs. 151.9±21.8 RFU/μm 2 , P <0.05) and eET-1 (66.3±8.7 vs. 146.6±20.7 RFU/μm 2 , P <0.05). Conclusion: ET-1 contributes to alterations in several pathways mediating endothelium-dependent relaxation in type-1 diabetes, leading to exaggerated endothelial dysfunction.

Xanthine oxidoreductase activity correlates with vascular endothelial dysfunction in patients with type 1 diabetes

2019 ◽  
Vol 57 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Kahori Washio ◽  
Yoshiki Kusunoki ◽  
Taku Tsunoda ◽  
Keiko Osugi ◽  
Mana Ohigashi ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Vascular Endothelial ◽  
Xanthine Oxidoreductase ◽  
Vascular Endothelial Dysfunction ◽  
Oxidoreductase Activity

scholarly journals Endothelial Dysfunction and Increased Arterial Intima-Media Thickness in Children With Type 1 Diabetes

Circulation ◽  
2004 ◽  
Vol 109 (14) ◽  
pp. 1750-1755 ◽  
Author(s):  
Mikko J. Järvisalo ◽  
Maria Raitakari ◽  
Jyri O. Toikka ◽  
Anne Putto-Laurila ◽  
Riikka Rontu ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Intima Media Thickness ◽  
Media Thickness ◽  
Arterial Intima

scholarly journals Diurnal Blood Pressure Abnormalities Are Related to Endothelial Dysfunction in Patients with Non-Complicated Type 1 Diabetes

2008 ◽  
Vol 31 (11) ◽  
pp. 2065-2073 ◽  
Author(s):  
Oguzhan Deyneli ◽  
Dilek Yazici ◽  
Ahmet Toprak ◽  
Meral Yuksel ◽  
Hasan Aydin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Endothelial Dysfunction

Correlation of microvascular abnormalities and endothelial dysfunction in Type-1 Diabetes Mellitus (T1DM): A real-time intravital microscopy study

2009 ◽  
Vol 42 (4) ◽  
pp. 285-295 ◽  
Author(s):  
Anthony T.W. Cheung ◽  
M. Meighan (Smith) Tomic ◽  
Peter C.Y. Chen ◽  
Eric Miguelino ◽  
Chin-Shang Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Type 1 Diabetes Mellitus ◽  
Real Time ◽  
Intravital Microscopy ◽  
Microscopy Study

scholarly journals Longitudinal Association Between Endothelial Dysfunction, Inflammation, and Clotting Biomarkers With Subclinical Atherosclerosis in Type 1 Diabetes: An Evaluation of the DCCT/EDIC Cohort

Diabetes Care ◽  
2015 ◽  
Vol 38 (7) ◽  
pp. 1281-1289 ◽  
Author(s):  
Kelly J. Hunt ◽  
Nathaniel L. Baker ◽  
Patricia A. Cleary ◽  
Richard Klein ◽  
Gabriel Virella ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Subclinical Atherosclerosis ◽  
Longitudinal Association
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