scholarly journals Dysglycemia and a History of Reproductive Risk Factors

Diabetes Care ◽  
2008 ◽  
Vol 31 (8) ◽  
pp. 1635-1638 ◽  
Author(s):  
S. D. McDonald ◽  
S. Yusuf ◽  
P. Sheridan ◽  
S. S. Anand ◽  
H. C. Gerstein ◽  
...  
2015 ◽  
Vol 14 (3) ◽  
pp. 258-264 ◽  
Author(s):  
Vaishali R Mohite ◽  
Asha K Pratinidhi ◽  
Rajsinh Vishwasrao Mohite

Background: Breast cancer is the most common type of cancer in women and is influenced by reproductive factors perceived by women worldwide.Aims: To identify the reproductive risk factors of breast cancer in newly diagnosed cases and to find out the strength of association of the risk factors with the breast cancer. Material and Methods: A hospital based case-control study was conducted in Satara district, India during year 2009 to 2011 among newly diagnosed cases of breast cancer and matched controls. A total of 434 participants including 217 cases and 217 controls were enrolled by purposive sampling technique from selected hospitals of study area. The information was collected by employing pre-tested questionnaire by utilizing interview method. Statistical Analysis used: Descriptive statistics, Odds ratio and Chi-square test was used to find out strength of association and statistical significant difference. Results: Highest proportion [31.80%] breast cancer cases was in age group 40-49 years with lowest age of 25 years at diagnosis of the disease. A very high proportion of both cases [88.02%] and controls [67.28%] were Hindu by religion and were from rural residence. Maximum proportion of breast cancer cases were housewives [63.59%], literate [71.42%] and from upper economic class [56.68%]. The proportions of cases were higher as compared to the controls with respect to risk factors like unmarried status, nulliparity, history of abortion, post menopausal status, absence of breast feeding and the history of exposure to hormonal contraceptives. The risk of getting breast cancer as indicated by Odds ratio was 8 times higher in unmarried women, 2.8 times in nulliparous women, 2.4 times with post menopausal status, 10.4 times with absence of breast feeding, 1.5 times with exposure to hormonal contraceptives and 4.5 times with history of ovarian disease respectively. Conclusion: The reproductive risk factors such as unmarried status of women, nulliparity, menopause, absence of breast feeding, history of ovarian disease and use of contraceptives were strongly associated with breast cancer.Bangladesh Journal of Medical Science Vol.14(3) 2015 p.258-264


Maturitas ◽  
2018 ◽  
Vol 107 ◽  
pp. 110-115 ◽  
Author(s):  
Hannah Elena Suhrs ◽  
Anna Meta Kristensen ◽  
Anna Bay Rask ◽  
Marie Mide Michelsen ◽  
Daria Frestad ◽  
...  

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Ghada M. Ezzat ◽  
Mahmoud H. El-Shoeiby

Abstract Background DNA methylation is associated with the risk factors of breast cancer. However, the impact of the reproductive and non-reproductive risk factors of breast cancer on p14/ARF methylation is not well known. Therefore, we investigated the relationships between p14/ARF methylation percentage and risk factors of breast cancer including age, family history, obesity, and reproductive risk factors in 120 breast cancer-free subjects; 60 women with a first-degree family history of breast cancer and 60 age-matched women with no family history of breast cancer. Extracted DNA from the whole blood was bisulfite-treated by EZ DNA modification kit. Quantitative methylation of p14/ARF was analyzed by methylation-specific PCR then methylation percentage of p14/ARF was calculated. Results P14/ARF methylation percentage was not related to any of the risk factors of breast cancer except age. Our study showed that p14/ARF methylation percentage was significantly higher in females with age ≥ 40 years than in females with age <  40 years (p=0.029). Also, a positive significant correlation between the p14/ARF methylation percentage and age was detected (r = 0.285, p = 0.014). Furthermore, univariate regression analysis showed that the age is independently associated with high p14/ARF methylation percentage (β = 1. 46, p = 0.029). Conclusion Among healthy females, the age is strongly linked to the peripheral p14/ARF methylation percentage. The present study suggests that p14/ARF methylation is not associated with other breast cancer risk factors. These results need oncoming research on a large cohort to define the interactions between p14/ARF methylation and the risk factors of breast cancer.


2016 ◽  
Vol 11 (1) ◽  
pp. 47-50
Author(s):  
Pooja Paudyal ◽  
Neelam Pradhan ◽  
Neebha Ojha

Aims: The aim of this study was to analyze the non-reproductive risk factors associated with uterovaginal prolapse (UVP) which is a major health concern of women.Methods: This was a hospital-based case control study, carried out in the Gynaecology Department of Tribhuvan University Teaching Hospital (TUTH) over one year from 13th April 2011 to 12th April 2012). Cases comprised of 116 women with UVP, second degree or more and controls were women without prolapse of the same age group within five years admitted subsequently after the cases. The variables studied were medical disorders like chronic obstructive  pulmonary disease (COPD)/chronic cough, constipation; smoking, family history of prolapse and body mass index (BMI). The p-value and odds ratio (OR) for each risk factor were calculated. Multivariate analysis was done for those risk factors found to be significant from the univariate analysis. Results: Smoking, family history of prolapse and low BMI were found to be significant risk factors from univariate analysis. Only two risk factors- family history of prolapse with OR 5.52 (2.11-14.49) and being underweight with OR 15.38 (1.88-125), were found to be significant by multivariate analysis.Conclusion: Providing good nutrition and preventing malnourishment in postmenopausal women, imparting awareness about increased risk in women with history of prolapse in first degree relatives and educating about the perils of smoking could contribute in  reducing morbidity due to prolapse.


1994 ◽  
Vol 59 (4) ◽  
pp. 476-482 ◽  
Author(s):  
Bishwa Nath Mukherjee ◽  
Subrata Sengupta ◽  
Salil Chaudhuri ◽  
Liton Naha Biswas ◽  
Pradip Maiti

Vrach ◽  
2019 ◽  
Vol 30 (8) ◽  
Author(s):  
S. Babanov ◽  
L. Strizhakov ◽  
I. Agarkova ◽  
Yu. Tezikov ◽  
I. Lipatov

1996 ◽  
Vol 10 (2) ◽  
pp. 186-196 ◽  
Author(s):  
Christina A. Kuenneth ◽  
Coleen Boyle ◽  
Catherine C. Murphy ◽  
Marshalyn Yeargin-Allsopp

Urology ◽  
2011 ◽  
Vol 77 (3) ◽  
pp. 570-575 ◽  
Author(s):  
John W. Warren ◽  
Daniel J. Clauw ◽  
Ursula Wesselmann ◽  
Patricia W. Langenberg ◽  
Fred M. Howard ◽  
...  

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