scholarly journals Mixed-Meal Tolerance Test Versus Glucagon Stimulation Test for the Assessment of  -Cell Function in Therapeutic Trials in Type 1 Diabetes

Diabetes Care ◽  
2008 ◽  
Vol 31 (10) ◽  
pp. 1966-1971 ◽  
Author(s):  
C. J. Greenbaum ◽  
T. Mandrup-Poulsen ◽  
P. F. McGee ◽  
T. Battelino ◽  
B. Haastert ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cell Function ◽  
Tolerance Test ◽  
Stimulation Test ◽  
Glucagon Stimulation Test ◽  
Mixed Meal ◽  
Meal Tolerance Test ◽  
Therapeutic Trials ◽  
Mixed Meal Tolerance Test

scholarly journals Urine C-Peptide Creatinine Ratio Is a Noninvasive Alternative to the Mixed-Meal Tolerance Test in Children and Adults With Type 1 Diabetes

Diabetes Care ◽  
2011 ◽  
Vol 34 (3) ◽  
pp. 607-609 ◽  
Author(s):  
R. E. J. Besser ◽  
J. Ludvigsson ◽  
A. G. Jones ◽  
T. J. McDonald ◽  
B. M. Shields ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Tolerance Test ◽  
Creatinine Ratio ◽  
Mixed Meal ◽  
C Peptide ◽  
Meal Tolerance Test ◽  
Mixed Meal Tolerance Test

scholarly journals Effects of mixed meal tolerance test on gastric emptying, glucose and lipid homeostasis in obese nonhuman primates

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kamal Albarazanji ◽  
Andrea R. Nawrocki ◽  
Bin Gao ◽  
Xiaoli Wang ◽  
Yixin Wang ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Glucose Homeostasis ◽  
Plasma Glucose ◽  
Nonhuman Primates ◽  
Surrogate Marker ◽  
Tolerance Test ◽  
Mixed Meal ◽  
C Peptide ◽  
Meal Tolerance Test ◽  
Mixed Meal Tolerance Test

AbstractMeal ingestion elicits a variety of neuronal, physiological and hormonal responses that differ in healthy, obese or diabetic individuals. The mixed meal tolerance test (MMTT) is a well-established method to evaluate pancreatic β-cell reserve and glucose homeostasis in both preclinical and clinical research in response to calorically defined meal. Nonhuman primates (NHPs) are highly valuable for diabetic research as they can naturally develop type 2 diabetes mellitus (T2DM) in a way similar to the onset and progression of human T2DM. The purpose of this study was to investigate the reproducibility and effects of a MMTT containing acetaminophen on plasma glucose, insulin, C-peptide, incretin hormones, lipids, acetaminophen appearance (a surrogate marker for gastric emptying) in 16 conscious obese cynomolgus monkeys (Macaca fascicularis). Plasma insulin, C-peptide, TG, aGLP-1, tGIP, PYY and acetaminophen significantly increased after meal/acetaminophen administration. A subsequent study in 6 animals showed that the changes of plasma glucose, insulin, C-peptide, lipids and acetaminophen were reproducible. There were no significant differences in responses to the MMTT among the obese NHPs with (n = 11) or without (n = 5) hyperglycemia. Our results demonstrate that mixed meal administration induces significant secretion of several incretins which are critical for maintaining glucose homeostasis. In addition, the responses to the MMTTs are reproducible in NHPs, which is important when the MMTT is used for evaluating post-meal glucose homeostasis in research.

Mixed Meal Tolerance Test and Reactive Hypoglycemia

1982 ◽  
Vol 14 (06) ◽  
pp. 281-283 ◽  
Author(s):  
R. Buss ◽  
P. Kansal ◽  
R. Roddam ◽  
J. Pino ◽  
B. Boshell
Keyword(s):  
Tolerance Test ◽  
Mixed Meal ◽  
Meal Tolerance Test ◽  
Reactive Hypoglycemia ◽  
Mixed Meal Tolerance Test
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