scholarly journals Distinct Component Profiles and High Risk Among African Americans With Metabolic Syndrome: The Jackson Heart Study

Diabetes Care ◽  
2008 ◽  
Vol 31 (6) ◽  
pp. 1248-1253 ◽  
Author(s):  
H. Taylor ◽  
J. Liu ◽  
G. Wilson ◽  
S. H. Golden ◽  
E. Crook ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
African Americans ◽  
Jackson Heart Study ◽  
Distinct Component ◽  
Heart Study

Abstract P439: Risk Factor Profile and Prevalence of Subclinical Disease in African Americans with Diabetes and Metabolic Syndrome: The Jackson Heart Study

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Kamel A Gharaibeh ◽  
Vanessa Xanthakis ◽  
Jung Hye Sung ◽  
Tandaw S Samdarshi ◽  
Herman A Taylor ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
African Americans ◽  
Left Ventricular ◽  
Jackson Heart Study ◽  
Cvd Risk ◽  
Metabolic Derangement ◽  
Risk Factor Profile ◽  
Subclinical Disease ◽  
Heart Study

Background . Metabolic derangements such as diabetes (DM) and metabolic syndrome (MetS) are common in African Americans (AA) and contribute to the higher cardiovascular disease (CVD) mortality in this group. A greater prevalence of subclinical disease (ScD) among those with DM and MetS in the AA community may be an explanatory factor. Objective . We assessed the CVD risk factor profile and distribution of ScD among AA with DM and MetS in the Jackson Heart Study (JHS). Methods . We evaluated 4,365 AA participants [mean age (SD) of 53.8 (12.3) years, 64.5% women] free of overt CVD who attended JHS Exam 1 (between 2000- 2004), when ScD assessment was routinely performed(with the exception of CT for coronary calcium that occurred in Exam2). SCD measures included 1) peripheral artery disease (PAD, defined as ankle-brachial index<0.9), 2) high coronary artery calcium (CAC, defined as score>100), 3) left ventricular (LV) hypertrophy (LVH defined as left ventricular mass index>51 g/m 2.7 , 4) low LV ejection fraction (low EF, defined as an EF<50%), and 5) microalbuminuria (MA, defined as an albumin-to-creatinine ratio>25 μg/mg in men and >35 μg/mg in women). We compared the distribution of standard CVD risk factors and ScD prevalence in 1) those without DM or MetS (referent), 2) those with MetS but no DM and 3) those with DM. Results . In our study sample, 1,089 (24.9%) had MetS with no DM and 752 (17.2%) had DM. Compared to the referent group, groups with metabolic derangement tended to be older, female, hypertensive, obese, and had lower HDL, higher fasting glucose, and higher triglycerides levels. Table 1 compares the distribution of ScD for the three groups, and demonstrates the greater odds of. CAC, LVH and microalbuminuria in participants with MetS or DM. Conclusion . In our large community-based sample of AAs, we observed a significantly high prevalence of ScD overall, especially so in participants with MetS and DM. These findings likely contribute to the high CVD rates in AA with MetS and DM. -->

Abstract P159: Coronary Artery Calcium Score Improves the Net Reclassification Index of Prevalent Cardiovascular Disease In African Americans: The Jackson Heart Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Joseph Yeboah ◽  
Che L Smith ◽  
Mario Sims ◽  
Ervin Fox ◽  
Yaorong Ge ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Artery ◽  
High Risk ◽  
African Americans ◽  
Diagnostic Accuracy ◽  
Coronary Artery Calcium ◽  
Smoking Status ◽  
Jackson Heart Study ◽  
Net Reclassification Improvement ◽  
Heart Study

Background: Prior studies suggest that African Americans (AA) have lower prevalence of coronary artery calcium (CAC) compared to whites, yet CAC has similar ability to predict coronary heart disease (CHD) events. The role of CAC as a screening tool for CHD risk in AA is unclear. We compared the diagnostic accuracy for CHD prevalence using the CAC score and the Framingham Risk Score (FRS) in an adult population of AA. Methods: CAC was measured in 2944 participants in the Jackson Heart Study, an NHLBI funded study of AA based in Jackson, MS. Approximately 8% of this cohort had known cardiovascular disease (CVD) defined as prior MI, angina, stroke, PTCA, CABG or PVD. Logistic regression, ROC and net reclassification index (NRI) analysis were used adjusting for age, gender, SBP, total and HDL cholesterol, smoking status, DM and BMI. FRS was calculated and those with DM were classified as high risk. Results: The mean age was 60, 65% were females, 26% had DM, 50% were obese and 30% were current or former smokers. Prevalent CVD was associated with older age, higher SBP, lower HDL and total cholesterol, and higher CAC. CAC was independently associated with prevalent CVD in our multivariable model [OR (95% CI): 1.26 (1.17, 1.35), p< 0.0001]. In ROC analysis, CAC improved the diagnostic accuracy (c statistic) of the FRS from 0.617 to 0.757 (p < 0.0001) for prevalent CVD. The FRS classified 30% of the cohort as high risk, 38.5% as intermediate risk and 31.5% as low risk. FRS classfied 51% of subjects with prevalent CVD as high risk. Addition of CAC to FRS resulted in net reclassification improvement of 4% for subjects with known CVD and 28.5% in those without CVD (see figure). Conclusion: In AA, the CAC is independently associated with prevalent CVD and improves the diagnostic accuracy of FRS for prevalent CVD by 14%. Addition of CAC improves the NRI of those with prevalent CVD by 4% and the NRI of individuals without CVD by 28.5%. Determination of CAC in AA may be useful in identifying individuals at risk of CVD and reclassifying individuals with low and intermediate FRS.

scholarly journals Association of psychosocial stressors with metabolic syndrome severity among African Americans in the Jackson Heart Study

2018 ◽  
Vol 90 ◽  
pp. 141-147 ◽  
Author(s):  
Michelle I. Cardel ◽  
Yuan-I Min ◽  
Mario Sims ◽  
Solomon K. Musani ◽  
Akilah Dulin-Keita ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
African Americans ◽  
Psychosocial Stressors ◽  
Jackson Heart Study ◽  
Heart Study

scholarly journals Prevalence, associated factors and heritabilities of metabolic syndrome and its individual components in African Americans: the Jackson Heart Study

BMJ Open ◽  
2015 ◽  
Vol 5 (10) ◽  
pp. e008675 ◽  
Author(s):  
Rumana J Khan ◽  
Samson Y Gebreab ◽  
Mario Sims ◽  
Pia Riestra ◽  
Ruihua Xu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
African Americans ◽  
Associated Factors ◽  
Jackson Heart Study ◽  
Heart Study

scholarly journals Metabolic syndrome and masked hypertension among African Americans: The Jackson Heart Study

2017 ◽  
Vol 19 (6) ◽  
pp. 592-600 ◽  
Author(s):  
Lisandro D. Colantonio ◽  
D. Edmund Anstey ◽  
April P. Carson ◽  
Gbenga Ogedegbe ◽  
Marwah Abdalla ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
African Americans ◽  
Masked Hypertension ◽  
Jackson Heart Study ◽  
Heart Study

Abstract P015: Plasma Brain Natriuretic Peptide Concentration Is Inversely Associated With Prevalent Metabolic Syndrome and Metabolic Syndrome Components: Findings From the Jackson Heart Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Harsha Nagarajarao ◽  
Solomon K Musani ◽  
Vasan S Ramachandran ◽  
Aurelian Bidulescu ◽  
Herman A Taylor ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
African Americans ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Assessment Model ◽  
Jackson Heart Study ◽  
Men And Women ◽  
Plasma Brain Natriuretic Peptide ◽  
Heart Study ◽  
Metabolic Syndrome Components

Introduction: There is emerging evidence that brain natriuretic peptide (BNP) may play a role in human metabolism. Suppressed concentrations in BNP in obese individuals may contribute to clinical phenotypes of metabolic syndrome. There is limited data on the relation of BNP to metabolic syndrome in African Americans. Methods: To assess the association between plasma brain natriuretic peptide (BNP) concentration and metabolic syndrome (MetS) and MetS risk factors in blacks, we analyzed cross-sectional data from 3,729 Jackson Heart Study participants free of heart failure (mean age, 54 years; 64% women). We performed sex-specific Tobit regression analysis on log transformed BNP to account for the left censored BNP distribution and adjusted for clinical and echocardiographic variables. Prevalence of MetS was 44% and 35% in women and men, respectively. We estimated percent changes for the underlying variables by back-transformation. Results: Plasma BNP concentration was inversely associated with metabolic syndrome components (fasting glucose and waist circumference in both men and women; and triglycerides in women). Sex-specific multivariable adjusted BNP concentrations were significantly lower in subjects with MetS than those without. In men, BNP concentration was 35% lower (P < 0.0001); and in women it was 31% lower (P < 0.0001). Men and women with insulin resistance represented by elevated homeostasis assessment model (HOMA-IR) index had significantly (P < 0.0001) lower BNP concentration compared to those with low HOMA-IR index. Discussion and Conclusion: We found in a community based cohort of African Americans a significant relation of low BNP concentration to MetS and individual components of MetS. This data supports a growing body of evidence that BNP plays a potential crucial role in total body metabolism.

Abstract 023: Left Ventricular Hypertrophy and Elevated Biomarkers of Chronic Myocardial Injury May Identify African Americans With a Very High Risk for Heart Failure Development: Findings From The Jackson Heart Study

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Ambarish PANDEY ◽  
Neil Keshvani ◽  
Colby Ayers ◽  
Adolfo Correa ◽  
Mark Drazner ◽  
...  
Keyword(s):  
High Risk ◽  
African Americans ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Myocardial Injury ◽  
Significant Risk ◽  
Left Ventricular ◽  
Jackson Heart Study ◽  
Heart Study

Introduction: African Americans (AA) have a disproportionate greater burden of risk factors and higher risk of HF than Whites. However, the factors underlying the transition from at-risk to clinical HF in AA is not well understood. We aimed to examine the independent and joint effects of subclinical myocardial injury, as measured by highly sensitive assays for cardiac troponin (hs-TnI) and left ventricular hypertrophy (LVH), on risk of HF in AA. Methods: Participants from the Jackson Heart Study, a prospective study of AA adults, without prevalent HF at baseline (2000-2004) were stratified into categories based on elevation in hs-cTnI (>6 ng/L) and presence of LVH (LV mass > 96 g/m 2 in women and > 116 g/m 2 in men). The risk of incident HF across different LVH and hs-cTnI groups was assessed using adjusted Cox models. Results: We included 3,796 participants (54 y, 64% women, 17.2% with elevated hs-TnI & 6.1% with LVH) with median follow up of 9.8 y and 285 incident HF events. In adjusted analyses, LVH and higher hs-TnI at baseline were independently associated with risk of HF [HR (95% CI): LVH (vs. no LVH) = 2.2(1.6 - 2.9); Log hs-cTnI (per unit higher)=1.6(1.5 - 1.8)]. A significant interaction was observed between LVH and hs-TnI for the risk of HF (p-int < 0.0001) with the highest risk among individuals with both LVH and elevated hs-TnI [43% incidence, HR (95% CI): 5.7(3.9 - 8.2)]. In contrast, LVH in absence of hs-TnI elevation was not associated with HF risk [ Figure ]. Among 2,367 participants with repeat assessment of hs-TnI at 5 year follow-up, increase in hs-TnI levels on follow-up was also associated with significantly higher risk of HF [HR (95% CI) per 1 unit increase = 1.03 (1.02 - 1.06)] Conclusions: The combination of LVH and elevated hs-TnI levels identifies a malignant preclinical HF phenotype in AAs with a remarkably high absolute risk of HF over a 10-year f/u period. Longitudinal increase in hs-TnI levels is also associated with significant risk of HF. Targeting these high-risk subsets may be an important strategy to mitigate HF risk in blacks.

scholarly journals The Association between Individual and Combined Components of Metabolic Syndrome and Chronic Kidney Disease among African Americans: The Jackson Heart Study

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e101610 ◽  
Author(s):  
Vincent L. Mendy ◽  
Mario J. Azevedo ◽  
Daniel F. Sarpong ◽  
Sylvia E. Rosas ◽  
Olugbemiga T. Ekundayo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
African Americans ◽  
Kidney Disease ◽  
Jackson Heart Study ◽  
Heart Study

Discrimination Associated with Metabolic Syndrome among African Americans from the Jackson Heart Study

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Gao X ◽  
◽  
Liu J ◽  
Bidulescu A ◽  
◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Metabolic Syndrome ◽  
African Americans ◽  
Disease Risk ◽  
Fasting Blood Glucose ◽  
Z Score ◽  
Jackson Heart Study ◽  
Prediction Ability ◽  
Underlying Assumption ◽  
Heart Study

We enthusiastically read the paper entitled “Experiences of Discrimination Are Associated with Worse Metabolic Syndrome Severity Among African Americans in the Jackson Heart Study” by Cardel et al. [1]. Despite the detected association between experiences of discrimination and metabolic syndrome (MetS) severity (using the Z-score described), some limitations in the methodology should be further discussed. First, the validity of the MetS Z-score used remains debatable. The underlying assumption in the calculation of this Z-score is based on simultaneous use of the known five biomarkers namely blood pressure, fasting blood glucose, abdominal fat/circumference, fasting blood triglycerides, and fasting blood high-density cholesterol as a cluster of circumstances that bundle together to define MetS by Adult Treatment Panel III (ATP III) criteria [2]. Even though previous research may be in support of this approach [3-6], the assumption has major limitations. Each biomarker has a defined threshold, with the value above that threshold showing a certain amount of future cardiovascular and metabolic disease risk. However, the value below that threshold has no distinct risk prediction capability. In other words, adding these biomarker scores together has more limited prediction ability because any increase risk detected by these individual biomarkers only increases the opportunity of creating a new parameter with relatively lower prediction ability. As an exemplification; in this study, there are higher baseline MetS scores among the older / aging participants, especially in 46 to 64 years group. Nevertheless this phenomenon is expected given that 1) interaction with time will enhance the correlation; and 2) the MetS older individuals criteria is determined by extreme measurements of at least three MetS biomarkers [2]. Second, although the prevalence of MetS diagnosed by ATP III is ascertained, the authors did not provide any data to compare proposed MetS Z-score with traditional ATP III dichotomous criteria to see whether the effect of discrimination on MetS is different. If there is no significantly better prediction of discrimination for MetS between the two methods, why MetS Z-score should be calculated and used? Third, the linkage between discrimination and MetS remains unclear (and underdeveloped) because 1) MetS is the risk predictor for later cardiovascular and metabolic disease instead of the health outcome caused by certain psychological factor like discrimination [2]; and 2) the process that affects MetS development is complex. Both intrapersonal determinants like awareness and interpersonal factors like social network may contribute to MetS progression. Therefore, a theoretical mechanism/model for discrimination associated with MetS is needed to unravel the interplay with personal and societal correlates that can holistically describe how MetS progresses among African Americans. Clearly, the statistical approach used to generate MetS Z-score warrants further validation. A theorized framework supporting the relationship between the MetS and its predictive ability is needed in order to explain how MetS’ consequences develop and inform future use of MetS per se or its derived Z-score for risk assessment.

scholarly journals Neighborhood social environment as risk factors to health behavior among African Americans: The Jackson Heart Study

2017 ◽  
Vol 45 ◽  
pp. 199-207 ◽  
Author(s):  
Xu Wang ◽  
Amy H. Auchincloss ◽  
Sharrelle Barber ◽  
Stephanie L. Mayne ◽  
Michael E. Griswold ◽  
...  
Keyword(s):  
Risk Factors ◽  
African Americans ◽  
Health Behavior ◽  
Social Environment ◽  
Jackson Heart Study ◽  
Heart Study
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