scholarly journals Skin Autofluorescence: A tool to identify type 2 diabetic patients at risk for developing microvascular complications

Diabetes Care ◽  
2007 ◽  
Vol 31 (3) ◽  
pp. 517-521 ◽  
Author(s):  
E. G. Gerrits ◽  
H. L. Lutgers ◽  
N. Kleefstra ◽  
R. Graaff ◽  
K. H. Groenier ◽  
...  
Keyword(s):  
At Risk ◽  
Microvascular Complications ◽  
Diabetic Patients ◽  
Skin Autofluorescence ◽  
Type 2 Diabetic Patients ◽  
Patients At Risk ◽  
Type 2 Diabetic

scholarly journals Serum Levels of Progranulin Are Closely Associated with Microvascular Complication in Type 2 Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Lin Xu ◽  
Bo Zhou ◽  
Huixia Li ◽  
Jiali Liu ◽  
Junhui Du ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Microvascular Complications ◽  
Linear Regression Analysis ◽  
Serum Levels ◽  
Diabetic Microangiopathy ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Objective. Progranulin (PGRN) was recently introduced as a novel marker of chronic inflammatory response in obesity and type 2 diabetes capable of directly affecting the insulin signaling pathway. This study aimed to investigate the correlation between PGRN and type 2 diabetics with microvascular complications.Methods. PGRN serum levels and glucose metabolism related substance were measured in 84 type 2 diabetic patients with or without microangiopathies and 12 health persons. Further analyses of serum PGRN in different stages of diabetic microangiopathies were conducted.Results. Serum levels of PGRN were markedly higher in type 2 diabetic patients with microangiopathies. PGRN serum levels increased with the progress of diabetic microangiopathies with significantly highest values detectable in clinical diabetic nephropathy (CDN) and proliferative diabetic retinopathy (PDR) groups. Serum PGRN concentrations in all individuals positively and markedly correlated with systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), triglyceride (TG), urinary albumin excretion rate (UAER), blood urea nitrogen (BUN), creatinine (CRE), white blood cell (WBC), disease duration, IL-6, and TNF-α, while correlating negatively and significantly with eGFR. Multiple linear regression analysis showed that only UAER and CRE were independently associated with serum PGRN.Conclusion. PGRN might be considered as a marker for diabetic microangiopathy and its severity.

Pentosidine as a biomarker for microvascular complications in type 2 diabetic patients

2012 ◽  
Vol 10 (3) ◽  
pp. 239-245 ◽  
Author(s):  
Mohsen Kerkeni ◽  
Amel Saïdi ◽  
Hassan Bouzidi ◽  
Ahmed Letaief ◽  
Salim Ben Yahia ◽  
...  
Keyword(s):  
Microvascular Complications ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic
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