scholarly journals Alternative Methods of Insulin Sensitivity Assessment in Obese Children and Adolescents

Diabetes Care ◽  
2008 ◽  
Vol 31 (4) ◽  
pp. 802-804 ◽  
Author(s):  
S. M. Rossner ◽  
M. Neovius ◽  
S. M. Montgomery ◽  
C. Marcus ◽  
S. Norgren
Keyword(s):  
Insulin Sensitivity ◽  
Children And Adolescents ◽  
Alternative Methods ◽  
Obese Children ◽  
Sensitivity Assessment

scholarly journals Metabolic Syndrome in Italian Obese Children and Adolescents: Stronger Association with Central Fat Depot than with Insulin Sensitivity and Birth Weight

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Claudia Brufani ◽  
Danilo Fintini ◽  
Ugo Giordano ◽  
Alberto Enrico Tozzi ◽  
Fabrizio Barbetti ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Birth Weight ◽  
Insulin Sensitivity ◽  
Low Birth Weight ◽  
Children And Adolescents ◽  
Central Obesity ◽  
Obese Children ◽  
Obesity Index ◽  
Central Fat ◽  
Fat Depot

Aim. To evaluate whether body fat distribution, birth weight, and family history for diabetes (FHD) were associated with metabolic syndrome (MetS) in children and adolescents.Methods. A total of 439 Italian obese children and adolescents (5–18 years) were enrolled. Subjects were divided into 2 groups: prepubertal and pubertal. MetS was diagnosed according to the adapted National Cholesterol Education Program criteria. Birth weight percentile, central obesity index (measured by dual-energy X-ray absorptiometry), insulin sensitivity (ISI), and disposition index were evaluated. Multivariate logistic regression models were used to determine variables associated with MetS.Results. The prevalence of MetS was 17%, with higher percentage in adolescents than in children (21 versus 12%). In the overall population, central obesity index was a stronger predictor of MetS than insulin sensitivity and low birth weight. When the two groups were considered, central fat depot remained the strongest predictor of MetS, with ISI similarly influencing the probability of MetS in the two groups and birth weight being negatively associated to MetS only in pubertal individuals. Neither FHD nor degree of fatness was a significant predictor of MetS.Conclusion. Simple clinical parameters like increased abdominal adiposity and low birth weight could be useful tools to identify European obese adolescents at risk for metabolic complications.

The metabolic syndrome and insulin sensitivity in lean and obese children and adolescents

Appetite ◽  
2015 ◽  
Vol 89 ◽  
pp. 317
Author(s):  
C. Bøjsøe ◽  
C.E. Fonvig ◽  
C. Trier ◽  
A.A. Nissen ◽  
J.T. Kloppenborg ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Insulin Sensitivity ◽  
Children And Adolescents ◽  
Obese Children ◽  
The Metabolic Syndrome

scholarly journals Association of serum lipids with β-cell function in obese children and adolescents

2019 ◽  
Vol 8 (10) ◽  
pp. 1318-1323 ◽  
Author(s):  
Giorgio Bedogni ◽  
Andrea Mari ◽  
Alessandra De Col ◽  
Sofia Tamini ◽  
Amalia Gastaldelli ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Children And Adolescents ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Cell Function ◽  
Hdl Cholesterol ◽  
Sensitivity Index ◽  
Obese Children ◽  
Β Cell Function ◽  
Few Data

Few data are available on the association between serum lipids and insulin secretion (ISEC) in children. We evaluated the association of triglycerides (TG), HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) with ISEC in 1150 non-diabetic obese children and adolescents using multivariable robust median regression. The following models were employed: (1) IGI or incAUCR as the ISEC response variable; (2) QUICKI, OGIS, the Stumvoll index or the Matsuda insulin sensitivity index as the insulin sensitivity (ISEN) predictor; (3) TG, HDL-C and LDL-C as the predictors of interest; (4) 120-min glucose, age, sex and body mass index as confounders. LDL-C and TG were not associated with ISEC in any model. In three out of four IGI models, an increase of 1 interquartile range (IQR) of HDL-C was associated with a decrease of median incAUCR ranging from −9 (robust 95% CI −17 to −2) to −8 (−14 to −1) pmol/mmol. In two out of four incAUCR models, an increase of 1 IQR of HDL-C was associated with a decrease of median IGI ranging from −8 (−15 to −1) to −7 (−11 to −2) pmol/mmol. TG and LDL-C are not associated and HDL-C is inversely associated with ISEC in obese children and adolescents.

Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season

Metabolism ◽  
2008 ◽  
Vol 57 (2) ◽  
pp. 183-191 ◽  
Author(s):  
Ramin Alemzadeh ◽  
Jessica Kichler ◽  
Ghufran Babar ◽  
Mariaelena Calhoun
Keyword(s):  
Insulin Sensitivity ◽  
Children And Adolescents ◽  
Hypovitaminosis D ◽  
Obese Children
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