scholarly journals Plasma Resistin, Associated With Single Nucleotide Polymorphism -420, Is Correlated With Insulin Resistance, Lower HDL Cholesterol, and High-Sensitivity C-Reactive Protein in the Japanese General Population

Diabetes Care ◽  
2007 ◽  
Vol 30 (6) ◽  
pp. 1501-1506 ◽  
Author(s):  
H. Osawa ◽  
Y. Tabara ◽  
R. Kawamoto ◽  
J. Ohashi ◽  
M. Ochi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Single Nucleotide Polymorphism ◽  
General Population ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
Nucleotide Polymorphism ◽  
C Reactive Protein ◽  
Single Nucleotide ◽  
Reactive Protein ◽  
Japanese General Population

Correlation of C-reactive protein levels, gene polymorphism and platelets count in Dengue infection

2020 ◽  
pp. 1-16
Author(s):  
Sana Shamshad ◽  
Sara Khan ◽  
Ghazala Kaukab Raja ◽  
Muhammad Sheeraz Ahmad ◽  
Muhammad Javaid Asad ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Dengue Infection ◽  
Serum Levels ◽  
Amplification Refractory Mutation System ◽  
Acid Extraction ◽  
Nucleotide Polymorphism ◽  
C Reactive Protein ◽  
Single Nucleotide ◽  
Protein Levels ◽  
Reactive Protein

Abstract Objective: To determine the correlation of polymorphism in C-reactive protein gene with variation in serum levels in dengue patients. Methods: The cross-sectional study was conducted at Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi, Pakistan, from October 2017 to October 2018, and comprised blood samples from dengue patients which were used to measure the serum levels of C-reactive protein. Deoxyribonucleic acid extraction followed by tetra amplification-refractory mutation system polymerase chain reaction was done to analyse the genotype variation T>G for single nucleotide polymorphism rs199953854 using allele-specific primers. Correlation of serum C-reactive protein levels with the C-reactive protein polymorphism in dengue patients was explored. Data was analysed using SPSS 21. Results: Of the 200 patients, 108(54%) had very high C-reactive protein levels, 48(24%) had levels slightly higher than the upper limit, 14(7%) had low and 30(15%) had normal levels. Also, 162(81%) patients had low platelets count. Amplification of only T alleles was noted. Conclusion: C-reactive protein levels were found to be increased with suppressed platelets count in dengue patients. Single nucleotide polymorphism rs199953854 appeared to have no polymorphism. Key Words: C-reactive protein, Dengue infection, rs199953854, Continuous...

scholarly journals Association between C-Reactive Protein and Adiposity in Women

2009 ◽  
Vol 94 (10) ◽  
pp. 3969-3977 ◽  
Author(s):  
Murielle Bochud ◽  
Fabienne Marquant ◽  
Pedro-Manuel Marques-Vidal ◽  
Peter Vollenweider ◽  
Jacques S. Beckmann ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Single Nucleotide Polymorphism ◽  
Body Mass ◽  
Fat Mass ◽  
Lean Mass ◽  
Nucleotide Polymorphism ◽  
C Reactive Protein ◽  
Single Nucleotide ◽  
Reactive Protein

Context: The link between C-reactive protein (CRP) and adiposity deserves to be further explored, considering the controversial diabetogenic role of CRP. Objective: We explored the potential causal role of CRP on measures of adiposity. Design: We used a Mendelian randomization approach with the CRP and LEPR genes as instrumental variables in a cross-sectional Caucasian population-based study comprising 2526 men and 2836 women. Adiposity was measured using body mass index (BMI), fat and lean mass estimated by bioelectrical impedance, and waist circumference. Results: Log-transformed CRP explained by the rs7553007 single-nucleotide polymorphism tagging the CRP gene was significantly associated with BMI [regression coefficient: 1.22 (0.18; 2.25), P = 0.02] and fat mass [2.67 (0.65; 4.68), P = 0.01] but not with lean mass in women, whereas no association was found in men. Log-transformed CRP explained by the rs1805096 LEPR single-nucleotide polymorphism was also positively associated, although not significantly, with BMI or fat mass. The combined CRP-LEPR instrument explained 2.24 and 0.77% of CRP variance in women and men, respectively. Log-transformed CRP explained by this combined instrument was significantly associated with BMI [0.98 (0.32; 1.63), P = 0.004], fat mass [2.07 (0.79; 3.34), P = 0.001], and waist [2.09 (0.39; 3.78), P = 0.01] in women but not men. Conclusion: Our data suggest that CRP is causally and positively related to BMI in women and that this is mainly due to fat mass. Results on the combined CRP-LEPR instrument suggest that leptin may play a role in the causal association between CRP and adiposity in women. Results in men were not significant. Results in this study suggest that C-reactive protein is causally related to body mass index in women, and that this is mainly due to fat mass.

scholarly journals Association of the FTO rs9939609 Single Nucleotide Polymorphism With C-reactive Protein Levels

Obesity ◽  
2009 ◽  
Vol 17 (2) ◽  
pp. 330-334 ◽  
Author(s):  
Eva Fisher ◽  
Matthias B. Schulze ◽  
Norbert Stefan ◽  
Hans-Ulrich Häring ◽  
Frank Döring ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Nucleotide Polymorphism ◽  
C Reactive Protein ◽  
Single Nucleotide ◽  
Protein Levels ◽  
Reactive Protein ◽  
Fto Rs9939609

scholarly journals SAT-431 Insulin Resistance, Lipid Profile and High-Sensitivity C-Reactive Protein in Patients with Autoimmune Thyroiditis

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Celestino Neves ◽  
João Sérgio Neves ◽  
Miguel Pereira ◽  
Ana Oliveira ◽  
José Luís Medina ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Lipid Profile ◽  
Thyroid Function ◽  
Autoimmune Thyroiditis ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
Sensitivity Index ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Abstract Introduction: Thyroid function and autoimmunity has been associated with cardiovascular events in patients with autoimmune thyroiditis. Objectives: To evaluate the association between thyroid function, antithyroid antibodies levels, insulin resistance and markers of cardiovascular risk in patients with autoimmune thyroiditis. Methods: We evaluated 228 patients with autoimmune thyroiditis, 93.9 % female, with a mean age of 47.06 ± 15.35 years. We analyzed thyroid function, anti-thyroglobulin antibodies (anti-Tg), anti-thyroid peroxidase antibodies (anti-TPO), HOMA-IR, HOMA-B, QUICKI, HISI (Hepatic Insulin Sensitivity Index), WBISI (Whole-Body Insulin Sensitivity Index), the levels of lipid profile, high-sensitivity C-reactive protein (hs-CRP), homocysteine, folic acid, and vitamin B12. We defined 3 groups based on TSH levels: TSH between 0.35-2.49 µUI/ml, (n = 166), TSH between 2.50-4.94 µUI/ml, (n = 43) and TSH over 4.95 µUI/ml, (n = 19), and normal levels of free T4 and free T3. A 75-g OGTT was performed in the morning and blood samples were obtained every 30 min for 120 min for measurements of plasma glucose, insulin, and C-peptide. For the statistical analysis we used the Mann-Whitney test and Spearman correlations. Results are expressed as means ± SD or percentages. A two-tailed p<0.05 was considered statistically significant. Results: There were no significant differences regarding median age or median BMI between groups. We did not find any significant differences comparing group with TSH 0.35-2.49 and group with TSH 2.50-4.94, in all parameters evaluated. Group with TSH 2.50-4.94 had higher indexes of QUICKI (0.69 ± 0.39 vs 0.48 ± 0.13; p = 0.02) and HISI (79.83 ± 63.72 vs 41.73 ± 29.02; p = 0.01) than group with TSH over 4.95. The group with TSH over 4.95 demonstrated a higher index of HOMA-IR than group with TSH 2.50-4.94 (3.77 ± 2.93 vs 1.95 ± 1.24; p = 0.01). In the TSH 0.35-2.49 group we found significant correlations between TSH and HOMA-IR (r= 0.18; p = 0.01), total cholesterol and anti-TPO (r =0.23; p = 0.002), anti-Tg and HDL-cholesterol (r= -0.17; p=0.002), anti-Tg and triglycerides (r=0.34; p < 0.001), and anti-Tg and LDL-cholesterol (r=0.16; p=0.03). In the TSH 2.50-4.94 group we observed positive correlation between Apo A1 and HOMA-B (r=0.58; p<0.001), HOMA-IR and LDL-cholesterol (r=0.34; p=0.02) and WBISI and HDL-cholesterol (r=0.34; p=0.02). In the TSH over 4.95 group we observed a correlation between TSH and triglycerides (r=0.70; p<0.001) and between anti-Tg and hs-CRP (r=0.64; p=0.004). Conclusions: The association among TSH, lipid profile, insulin resistance, hs-CRP and antithyroid antibodies in patients with autoimmune thyroiditis may contribute to an increased cardiovascular risk, not only in patients with subclinical hypothyroidism but also in those classified as euthyroid.

Sign in / Sign up

Export Citation Format

Share Document