scholarly journals Perilipin Gene Variation Determines Higher Susceptibility to Insulin Resistance in Asian Women When Consuming a High-Saturated Fat, Low-Carbohydrate Diet

Diabetes Care ◽  
2006 ◽  
Vol 29 (6) ◽  
pp. 1313-1319 ◽  
Author(s):  
D. Corella ◽  
L. Qi ◽  
E. S. Tai ◽  
M. Deurenberg-Yap ◽  
C. E. Tan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Saturated Fat ◽  
Asian Women ◽  
Carbohydrate Diet ◽  
Gene Variation ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate

scholarly journals Limited Effect of Dietary Saturated Fat on Plasma Saturated Fat in the Context of a Low Carbohydrate Diet

Lipids ◽  
2010 ◽  
Vol 45 (10) ◽  
pp. 947-962 ◽  
Author(s):  
Cassandra E. Forsythe ◽  
Stephen D. Phinney ◽  
Richard D. Feinman ◽  
Brittanie M. Volk ◽  
Daniel Freidenreich ◽  
...  
Keyword(s):  
Saturated Fat ◽  
Carbohydrate Diet ◽  
Limited Effect ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate

scholarly journals Beneficial Effects of an 8-Week, Very Low Carbohydrate Diet Intervention on Obese Subjects

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Yunjuan Gu ◽  
Haoyong Yu ◽  
Yuehua Li ◽  
Xiaojing Ma ◽  
Junxi Lu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Body Composition ◽  
Metabolic Profile ◽  
Whole Body ◽  
Carbohydrate Diet ◽  
Beneficial Effects ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
Obese Subjects

Aim. To investigate the effects of weight loss during an 8-week very low carbohydrate diet (VLCD) on improvement of metabolic parameters, adipose distribution and body composition, and insulin resistance and sensitivity in Chinese obese subjects.Methods. Fifty-three healthy obese volunteers were given an 8-week VLCD. The outcomes were changes in anthropometry, body composition, metabolic profile, abdominal fat distribution, liver fat percent (LFP), and insulin resistance and sensitivity.Results. A total of 46 (86.8%) obese subjects completed the study. The VLCD caused a weight loss of−8.7±0.6 kg (mean ± standard error (SE),P<0.0001) combined with a significant improvement of metabolic profile. In both male and female, nonesterified fatty acid (NEFA) significantly decreased (−166.2±47.6 μmol/L,P=0.001) andβ-hydroxybutyric acid (BHA) increased (0.15±0.06 mmol/L,P=0.004) after eight weeks of VLCD intervention. The significant reductions in subcutaneous fat area (SFA), visceral fat area (VFA), and LFP were−66.5±7.9 cm2,−35.3±3.9 cm2, and−16.4±2.4%, respectively (allPvaluesP<0.0001). HOMA IR and HOMAβsignificantly decreased while whole body insulin sensitivity index (WBISI) increased (allPvaluesP<0.001).Conclusion. Eight weeks of VLCD was an effective intervention in obese subjects. These beneficial effects may be associated with enhanced hepatic and whole-body lipolysis and oxidation.

Abstract P165: The Long-term Effect of a Low-Carbohydrate Diet on Endothelial Dysfunction and Insulin Resistance: A Randomized Controlled Trial

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Tian Hu ◽  
Kristi Reynolds ◽  
Lu Yao ◽  
Calynn Bunol ◽  
Yanxi Liu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Endothelial Dysfunction ◽  
Adhesion Molecule ◽  
Low Fat ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Low Fat Diet ◽  
Low Carbohydrate ◽  
Study Participants

The long-term effects of low-carbohydrate diets versus low-fat diets on endothelial dysfunction and insulin resistance are unclear. A total of 148 study participants with a body mass index of 30 - 45 kg/m2 (Mean: 35.4 kg/m2) who were free of diabetes, cardiovascular diseases and kidney disease were recruited. The participants were randomly assigned to either a low-carbohydrate diet (<40 g/day; N=75) or a low fat (<30% energy from fat, <10% from saturated fat; N=73) diet. Two 24-hour dietary recalls were conducted at each clinic visit (0, 3, 6 and 12 months of intervention). Participants met with a study dietitian weekly for the first month followed by group settings bi-weekly for 5 months and monthly for the last 6 months. Each group was provided the same behavioral curriculum related to diet emphasizing portion control and eating habits. Biomarkers for endothelial function and insulin resistance included E-selectin, Intercellular Adhesion Molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), Insulin-like growth Factor-1 (IGF-1), serum insulin, and glucose. Mixed-effect regression models including group, time and their interaction were used to analyze the data. Of the study participants, 60 in the low-fat group (81.1%) and 59 in the low-carbohydrate group (79.7%) completed the entire intervention. The mean age was 46.8 years, 88.5% were women and 55.1% were African-Americans. The low-carbohydrate group lost approximately 3.5 kg more body weight than did the low-fat group (P= 0.002) on average. Compared to the low-fat diet, the low-carbohydrate diet resulted in greater reductions in E-selectin (net change: -4.5, -4.3, and -3.8 ng/mL at 3, 6, and 12 months, respectively; overall P= 0.002) and ICAM-1 (net change: -7.3, -10.4, and -16.8 ng/mL at 3, 6, and 12 months, respectively; overall P= 0.06). There was no significant change in any other markers. Our findings suggest that the low-carbohydrate is at least as effective as the low-fat diet at improving endothelial dysfunction and insulin resistance.

scholarly journals High saturated fat and low carbohydrate diet decreases lifespan independent of body weight in mice

2013 ◽  
Vol 2 (1) ◽  
Author(s):  
Alexandre Pastoris Muller ◽  
Marcelo de Oliveira Dietrich ◽  
Adriano Martimbianco de Assis ◽  
Diogo Onofre Souza ◽  
Luis Valmor Portela
Keyword(s):  
Body Weight ◽  
Saturated Fat ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate

scholarly journals Effects of Low-Carbohydrate versus Mediterranean Diets on Weight Loss, Glucose Metabolism, Insulin Kinetics and β-Cell Function in Morbidly Obese Individuals

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1345
Author(s):  
Domenico Tricò ◽  
Diego Moriconi ◽  
Rossana Berta ◽  
Simona Baldi ◽  
Alfredo Quinones-Galvan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Cell Function ◽  
Insulin Clearance ◽  
Morbidly Obese ◽  
Β Cell ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
Β Cell Function

Low-calorie Mediterranean-style or low-carbohydrate dietary regimens are widely used nutritional strategies against obesity and associated metabolic diseases, including type 2 diabetes. The aim of this study was to compare the effectiveness of a balanced Mediterranean diet with a low-carbohydrate diet on weight loss and glucose homeostasis in morbidly obese individuals at high risk to develop diabetes. Insulin secretion, insulin clearance, and different β-cell function components were estimated by modeling plasma glucose, insulin and C-peptide profiles during 75-g oral glucose tolerance tests (OGTTs) performed at baseline and after 4 weeks of each dietary intervention. The average weight loss was 5%, being 58% greater in the low-carbohydrate-group than Mediterranean-group. Fasting plasma glucose and glucose tolerance were not affected by the diets. The two dietary regimens proved similarly effective in improving insulin resistance and fasting hyperinsulinemia, while enhancing endogenous insulin clearance and β-cell glucose sensitivity. In summary, we demonstrated that a low-carbohydrate diet is a successful short-term approach for weight loss in morbidly obese patients and a feasible alternative to the Mediterranean diet for its glucometabolic benefits, including improvements in insulin resistance, insulin clearance and β-cell function. Further studies are needed to compare the long-term efficacy and safety of the two diets.

scholarly journals Effect of polyunsaturated and saturated fat intake as part of a low‐carbohydrate diet for weight loss.

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
Bridget A Cassady ◽  
Nicole L Charboneau ◽  
Emily E Brys ◽  
Kristen A Skime ◽  
Tonya J Pleschourt ◽  
...  
Keyword(s):  
Weight Loss ◽  
Saturated Fat ◽  
Fat Intake ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
Saturated Fat Intake

Low-carbohydrate diet disrupts the association between insulin resistance and weight gain

Metabolism ◽  
2009 ◽  
Vol 58 (8) ◽  
pp. 1116-1122 ◽  
Author(s):  
Jose O. Leite ◽  
Ryan DeOgburn ◽  
Joseph C. Ratliff ◽  
Randy Su ◽  
Jeff S. Volek ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Gain ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate
Sign in / Sign up

Export Citation Format

Share Document