scholarly journals Adipose Tissue Malfunction Drives Metabolic Dysfunction in Alström Syndrome

Diabetes ◽  
2021 ◽  
Vol 70 (2) ◽  
pp. 323-325
Author(s):  
Sona Kang
Keyword(s):  
Adipose Tissue ◽  
Metabolic Dysfunction ◽  
Alström Syndrome ◽  
Alstrom Syndrome

scholarly journals Relative Adipose Tissue Failure in Alström Syndrome Drives Obesity-Induced Insulin Resistance

Diabetes ◽  
2020 ◽  
pp. db200647
Author(s):  
Tarekegn Geberhiwot ◽  
Shanat Baig ◽  
Cathy Obringer ◽  
Dorothée Girard ◽  
Charlotte Dawson ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Alström Syndrome ◽  
Alstrom Syndrome

scholarly journals Advanced non-alcoholic fatty liver disease and adipose tissue fibrosis in patients with Alström syndrome

2016 ◽  
Vol 36 (11) ◽  
pp. 1704-1712 ◽  
Author(s):  
Laura L. Gathercole ◽  
Jonathan M. Hazlehurst ◽  
Matthew J. Armstrong ◽  
Rachel Crowley ◽  
Sarah Boocock ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Tissue Fibrosis ◽  
Alström Syndrome ◽  
Alstrom Syndrome ◽  
Alcoholic Fatty Liver Disease

scholarly journals Relative adipose tissue failure in Alström syndrome drives obesity-induced insulin resistance

2020 ◽  
Author(s):  
Ada Admin ◽  
Tarekegn Geberhiwot ◽  
Shanat Baig ◽  
Cathy Obringer ◽  
Dorothée Girard ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Therapeutic Strategies ◽  
Mice Model ◽  
Alström Syndrome ◽  
Monogenic Form ◽  
Depth Analysis ◽  
Alstrom Syndrome ◽  
Polygenic Obesity ◽  
First Time

Obesity is a major risk factor for insulin resistance (IR) and its attendant complications. The pathogenic mechanisms linking them remain poorly understood, partly due to a lack of intermediary monogenic human phenotypes. Here, we report on a monogenic form of IR-prone obesity, Alström syndrome (ALMS). Twenty-three subjects with monogenic or polygenic obesity underwent hyperinsulinaemic-euglycemic clamping with concomitant adipose tissue (AT) microdialysis and an in-depth analysis of subcutaneous AT histology. We have shown a relative adipose tissue failure in monogenic obese cohort; a finding supported by observations in a novel conditional mouse model (<i>Alms<sup>flin/flin</sup></i>) and ALMS1-silenced human primary adipocytes. Whereas, selective reactivation of ALMS1 gene in adipose tissue of an ALMS conditional knockdown mice model (<i>Alms<sup>flin/flin</sup>;Adipo-Cre<sup>+/-</sup></i>) restores systemic insulin sensitivity and glucose tolerance. Hence, we show for the first time the relative adipose tissue failure in human obese cohorts to be a major determinant of accelerated IR without evidence of lipodystrophy. These new insights into adipocyte driven insulin resistance may assist development of adipose tissue targeted therapeutic strategies for diabetes.

Liver fibrosis is common in Alstrom syndrome and can be identified using non-invasive tests

2014 ◽  
Author(s):  
Jonathan Hazlehurst ◽  
Matthew Armstrong ◽  
Jayne Hodgkiss ◽  
Rachel Crowley ◽  
Tarekegn Geberhiwot ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Non Invasive ◽  
Alström Syndrome ◽  
Alstrom Syndrome

44-OR: PAR2-Regulated MIF Secretion from Non-Immune Cells in Adipose Tissue Is a Key Mechanism Involved in the Development of Metabolic Dysfunction

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 44-OR
Author(s):  
YIHENG HUANG ◽  
LIUJUN CHEN ◽  
YADAN QI ◽  
DAKE QI
Keyword(s):  
Adipose Tissue ◽  
Immune Cells ◽  
Metabolic Dysfunction

scholarly journals Adipose Tissue Immunomodulation and Treg/Th17 Imbalance in the Impaired Glucose Metabolism of Children with Obesity

Children ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 554
Author(s):  
Stefania Croce ◽  
Maria Antonietta Avanzini ◽  
Corrado Regalbuto ◽  
Erika Cordaro ◽  
Federica Vinci ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glucose Metabolism ◽  
Th17 Cells ◽  
Metabolic Disorders ◽  
Potential Role ◽  
Immune Monitoring ◽  
Metabolic Dysfunction ◽  
Impaired Glucose Metabolism ◽  
T Cell Infiltration

In the last few decades, obesity has increased dramatically in pediatric patients. Obesity is a chronic disease correlated with systemic inflammation, characterized by the presence of CD4 and CD8 T cell infiltration and modified immune response, which contributes to the development of obesity related diseases and metabolic disorders, including impaired glucose metabolism. In particular, Treg and Th17 cells are dynamically balanced under healthy conditions, but imbalance occurs in inflammatory and pathological states, such as obesity. Some studies demonstrated that peripheral Treg and Th17 cells exhibit increased imbalance with worsening of glucose metabolic dysfunction, already in children with obesity. In this review, we considered the role of adipose tissue immunomodulation and the potential role played by Treg/T17 imbalance on the impaired glucose metabolism in pediatric obesity. In the patient care, immune monitoring could play an important role to define preventive strategies of pediatric metabolic disease treatments.

scholarly journals Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Anastasia Georgiadi ◽  
Valeria Lopez-Salazar ◽  
Rabih El- Merahbi ◽  
Rhoda Anane Karikari ◽  
Xiaochuan Ma ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Dependent Manner ◽  
Metabolic Dysfunction ◽  
Functional Interaction ◽  
White Adipocyte ◽  
White Adipocytes ◽  
Obesity And Diabetes ◽  
Adhesion Gpcr ◽  
Circulating Levels

AbstractThe proper functional interaction between different tissues represents a key component in systemic metabolic control. Indeed, disruption of endocrine inter-tissue communication is a hallmark of severe metabolic dysfunction in obesity and diabetes. Here, we show that the FNDC4-GPR116, liver-white adipose tissue endocrine axis controls glucose homeostasis. We found that the liver primarily controlled the circulating levels of soluble FNDC4 (sFNDC4) and lowering of the hepatokine FNDC4 led to prediabetes in mice. Further, we identified the orphan adhesion GPCR GPR116 as a receptor of sFNDC4 in the white adipose tissue. Upon direct and high affinity binding of sFNDC4 to GPR116, sFNDC4 promoted insulin signaling and insulin-mediated glucose uptake in white adipocytes. Indeed, supplementation with FcsFNDC4 in prediabetic mice improved glucose tolerance and inflammatory markers in a white-adipocyte selective and GPR116-dependent manner. Of note, the sFNDC4-GPR116, liver-adipose tissue axis was dampened in (pre) diabetic human patients. Thus our findings will now allow for harnessing this endocrine circuit for alternative therapeutic strategies in obesity-related pre-diabetes.

Hepatic dysfunction in two sibs with Alström syndrome: Case report and review of the literature

1997 ◽  
Vol 69 (1) ◽  
pp. 13-16 ◽  
Author(s):  
Midori Awazu ◽  
Tetsuya Tanaka ◽  
Seiji Sato ◽  
Makoto Anzo ◽  
Masataka Higuchi ◽  
...  
Keyword(s):  
Case Report ◽  
Hepatic Dysfunction ◽  
Review Of The Literature ◽  
Alström Syndrome ◽  
Alstrom Syndrome
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