751-P: First-in-Human, Single and Repeated Dose Study of SCO-267, a GPR40 Full Agonist, in Healthy Adults and Subjects with Glucose Intolerance

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 751-P
Author(s):  
HARUNOBU NISHIZAKI ◽  
OSAMU MATSUOKA ◽  
MEGURU ACHIRA ◽  
TOMOYA KAGAWA ◽  
MASANORI WATANABE ◽  
...  
Keyword(s):  
Glucose Intolerance ◽  
Healthy Adults ◽  
Repeated Dose ◽  
Full Agonist ◽  
Dose Study

Percellome toxicogenomics project: newly designed repeated dose study

2018 ◽  
Vol 295 ◽  
pp. S217
Author(s):  
J. Kanno ◽  
S. Kitajima ◽  
R. Ono ◽  
K. Aisaki
Keyword(s):  
Repeated Dose ◽  
Dose Study

scholarly journals Primaquine decreased plasma concentration of ritonavir: single- and repeated-dose study in Sprague Dawley rats

2011 ◽  
pp. 190
Author(s):  
Melva Louisa ◽  
Vivian Soetikno ◽  
Nafrialdi Nafrialdi ◽  
Rianto Setiabudy ◽  
Frans D. Suyatna
Keyword(s):  
Plasma Concentration ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Dose Study

scholarly journals Oral Repeated-Dose Toxicity Studies of Coenzyme Q10 in Beagle Dogs

2012 ◽  
Vol 31 (1) ◽  
pp. 58-69 ◽  
Author(s):  
Padmaja Yerramilli-Rao ◽  
M. Flint Beal ◽  
Dai Watanabe ◽  
Karl Kieburtz ◽  
Elisabeth A. de Blieck ◽  
...  
Keyword(s):  
Steady State ◽  
Coenzyme Q10 ◽  
Area Under The Curve ◽  
Phase Iii ◽  
Repeated Dose ◽  
Beagle Dogs ◽  
Time Curve ◽  
Repeated Dose Toxicity ◽  
Dose Study ◽  
Support Phase

To support phase III testing of coenzyme Q10 (CoQ10) in humans, we conducted pharmacokinetic and toxicology studies in beagle dogs. Following single gavage administration of CoQ10 at 600, 1200, 1800, or 2400 mg/kg per d no obvious dose response was observed in maximum concentration ( Cmax) or area under the curve (AUC) versus time curve at the 3 highest dosages. In a repeated-dose study of CoQ10 at 600, 1200, 1800, or 2400 mg/kg per d for 4 weeks, CoQ10 reached steady state in plasma by 2 weeks at all dosages. Both Cmax and AUC increased with increasing dosage of CoQ10. The highest plasma levels were recorded at 1800 mg/kg per d. In a 39-week chronic toxicity study of CoQ10 at 1200 and 1800 mg/kg per d or placebo, CoQ10 reached steady state in plasma by 13 weeks. Behaviors, blood chemistries, and detailed histopathology were normal. No deaths occurred. These results support the use of a 2400 mg/d dosage of CoQ10 in human clinical trials.

Safety of sucrose esters from Physalis peruviana L. in a 28-day repeated-dose study in mice

2017 ◽  
Vol 90 ◽  
pp. 850-862 ◽  
Author(s):  
Yanet C. Ocampo ◽  
Daneiva C. Caro ◽  
David E. Rivera ◽  
Luis A. Franco
Keyword(s):  
Repeated Dose ◽  
Sucrose Esters ◽  
Physalis Peruviana ◽  
Dose Study

Quantitative proteomic analysis of rat liver for carcinogenicity prediction in a 28-day repeated dose study

PROTEOMICS ◽  
2007 ◽  
Vol 7 (5) ◽  
pp. 781-795 ◽  
Author(s):  
Hidenori Yamanaka ◽  
Yoshikuni Yakabe ◽  
Koichi Saito ◽  
Masaru Sekijima ◽  
Tomoyuki Shirai
Keyword(s):  
Rat Liver ◽  
Proteomic Analysis ◽  
Repeated Dose ◽  
Quantitative Proteomic Analysis ◽  
Dose Study

scholarly journals Repeated dose kinetics of valproic acid in healthy adults.

1989 ◽  
Vol 15 (3) ◽  
pp. 188-193
Author(s):  
YASUO KODAMA ◽  
HIROO KIMOTO ◽  
FUMITAKA YASUNAGA ◽  
MASAE KURANARI ◽  
YUHEI TOGO ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Healthy Adults ◽  
Repeated Dose ◽  
Kinetics Of

scholarly journals The Rat Pig-a Mutation Assay in Single and 28 Day-repeated Dose Study of Cyclophosphamide: The PIGRET Assay Can Detect the In Vivo Mutagenicity Earlier than the RBC Pig-a Assay

2014 ◽  
Vol 36 (4) ◽  
pp. 191-198 ◽  
Author(s):  
Takafumi Kimoto ◽  
Satsuki Chikura ◽  
Kumiko Suzuki-Okada ◽  
Xiaomei Kobayashi ◽  
Yasuhiro Itano ◽  
...  
Keyword(s):  
Repeated Dose ◽  
Dose Study ◽  
In Vivo Mutagenicity ◽  
Mutation Assay
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