scholarly journals Tissue-specific splicing and dietary interaction of a mutant As160 allele determine muscle metabolic fitness in rodents

Diabetes ◽  
2021 ◽  
pp. db210039
Author(s):  
Xinyu Yang ◽  
Qiaoli Chen ◽  
Qian Ouyang ◽  
Ping Rong ◽  
Weikuan Feng ◽  
...  
Keyword(s):  
Tissue Specific ◽  
Dietary Interaction ◽  
Metabolic Fitness

scholarly journals Tissue-Specific Splicing and Dietary Interaction of a Mutant As160 Allele Determine Muscle Metabolic Fitness in Rodents

2021 ◽  
Author(s):  
Xinyu Yang ◽  
Qiaoli Chen ◽  
Qian Ouyang ◽  
Ping Rong ◽  
Weikuan Feng ◽  
...  
Keyword(s):  
Metabolic Disorders ◽  
Postprandial Hyperglycemia ◽  
Acid Oxidation ◽  
Metabolic Abnormalities ◽  
Glucose Utilisation ◽  
Dietary Interaction ◽  
Rat Myocytes ◽  
A Minor ◽  
Metabolic Fitness

<a>Ethnic groups are physiologically and genetically adapted to their diets. Inuit bear a frequent AS160<sup>R684X</sup> mutation that causes type 2 diabetes. Whether this</a> mutation evolutionarily confers adaptation in Inuit and how it causes metabolic disorders upon dietary changes are unknown due to limitations in human studies. Here, we develop a genetically-modified rat model bearing an orthologous AS160<sup>R693X</sup> mutation, which mimics human patients exhibiting postprandial hyperglycemia and hyperinsulinemia. Importantly, a sugar-rich diet aggravates metabolic abnormalities in AS160<sup>R693X</sup> rats. The AS160<sup>R693X</sup> mutation diminishes a dominant long-variant AS160 without affecting a minor short-variant AS160 in skeletal muscle, which suppresses muscle glucose utilisation but induces fatty acid oxidation. This fuel switch suggests a possible adaptation in Inuit who traditionally had lipid-rich hypoglycemic diets. Finally, induction of the short-variant AS160 restores glucose utilisation in rat myocytes and a mouse model. Our findings have implications for development of precision treatments for patients bearing the AS160<sup>R684X</sup> mutation.

scholarly journals Tissue-Specific Splicing and Dietary Interaction of a Mutant As160 Allele Determine Muscle Metabolic Fitness in Rodents

2021 ◽  
Author(s):  
Xinyu Yang ◽  
Qiaoli Chen ◽  
Qian Ouyang ◽  
Ping Rong ◽  
Weikuan Feng ◽  
...  
Keyword(s):  
Metabolic Disorders ◽  
Postprandial Hyperglycemia ◽  
Acid Oxidation ◽  
Metabolic Abnormalities ◽  
Glucose Utilisation ◽  
Dietary Interaction ◽  
Rat Myocytes ◽  
A Minor ◽  
Metabolic Fitness

<a>Ethnic groups are physiologically and genetically adapted to their diets. Inuit bear a frequent AS160<sup>R684X</sup> mutation that causes type 2 diabetes. Whether this</a> mutation evolutionarily confers adaptation in Inuit and how it causes metabolic disorders upon dietary changes are unknown due to limitations in human studies. Here, we develop a genetically-modified rat model bearing an orthologous AS160<sup>R693X</sup> mutation, which mimics human patients exhibiting postprandial hyperglycemia and hyperinsulinemia. Importantly, a sugar-rich diet aggravates metabolic abnormalities in AS160<sup>R693X</sup> rats. The AS160<sup>R693X</sup> mutation diminishes a dominant long-variant AS160 without affecting a minor short-variant AS160 in skeletal muscle, which suppresses muscle glucose utilisation but induces fatty acid oxidation. This fuel switch suggests a possible adaptation in Inuit who traditionally had lipid-rich hypoglycemic diets. Finally, induction of the short-variant AS160 restores glucose utilisation in rat myocytes and a mouse model. Our findings have implications for development of precision treatments for patients bearing the AS160<sup>R684X</sup> mutation.

Expression of sunflower cytochrome c mRNA is tissue-specific and controlled by nitrate and light

1997 ◽  
Vol 99 (2) ◽  
pp. 342-347 ◽  
Author(s):  
Silvina A. Felitti ◽  
Raquel L. Chan ◽  
Gabriela Gago ◽  
Estela M. Valle ◽  
Daniel H. Gonzalez
Keyword(s):  
Cytochrome C ◽  
Tissue Specific

Tissue-specific expression patterns of nuclear receptors

2013 ◽  
Author(s):  
AL Bookout ◽  
Y Jeong ◽  
M Downes ◽  
RT Yu ◽  
RM Evans ◽  
...  
Keyword(s):  
Nuclear Receptors ◽  
Expression Patterns ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression
Sign in / Sign up

Export Citation Format

Share Document